#Cytokines

Prof. Akiko Iwasaki

VirusesImmunity

An excellent new study by @BrodinPetter’s team on the differences between MIS-C and Kawasaki disease. This is incredibly timely and informative. Here are a couple of highlights. (1/)https://www.cell.com/cell/fulltext/S0092-8674(20)31157-0

Thiago Carvalho

CyrilPedia

So here's an interesting preprint from @carolilucas, @VirusesImmunity et al serially analysing "immune responses in 113 COVID-19 patients with moderate (non-ICU) and severe (ICU) disease."https://www.medrxiv.org/content/10.110

Jean-Jacques Fraslin - No #FakeMed

Fraslin

Le Dr Ryan Padgett, un urgentiste de Kirkland de 45 ans, en bonne santé, a survécu au #Covid19. Sous ventilateur, "ses collègues de l'hôpital l'ont mis sous hydroxychloroquine dont l'efficacité

Joanna Poole 💙

Jopo_dr

CRP - what I wish I’d been taught! This (large!) protein comes as a pentamer of units 23 k-daltons. It has equivalents in almost all species and is found on

Leo Reap

Leo_ReapDO

Proposed COVID-19 Pathophysiology [Part 2 of 3]:Enter the magnificent macrophage.What do #COVID-19 and hemophagocytic lymphohistiocytosis (#HLH) potentially have in common?...let’s continue our journey onward into the cytokine storm. First, let’s

Anjill 🕊

AnjillofLight_

1. I came over a report the other day, and then it hit me. This thread will explain what I realized [may] be happening. Disclosures: This is an exploratory thread.

Robert Plenge

rplenge

Increasing evidence points to monocytes and macrophages as key players in the maladaptive immune response to SARS-CoV-2 and the disease it causes, COVID-19. A thread with emphasis on key mechanisms

WesElyMD

WesElyMD

1/ Mechanism: Lung + Brain Injury in #COVID19: In the ICU w/ #COVID we are dealing w/ SEPSIS & ARDS…most of what goes wrong in the human body when it’s infected

Paula G.

MoonQuakerGirl

Most of you know that I’m a Chemist Research Scientist currently working for the US federal Government. Lately I've been inundated with many questions regarding to the #COVIDー19 outbreak. *THREAD*

Dr. Kohilathas

drkohilathas

Vitamin D, #Covid19, the elderly, obese and BME population - A THREADThanks to Dr John Campbell and @foundmyfitness Things to think about:Vit D reduces respiratory tract infections and severity.Those with

Dena Grayson, MD, PhD

DrDenaGrayson

A study of 175 #COVID19 patients discharged from hospital in #China showed *30% had extremely low levels of antibodies* with NO antibodies detected in ~6%.Low levels of antibodies could affect

Prof. Akiko Iwasaki

VirusesImmunity

This is a cautionary tale of how anti-Spike antibody may make COVID disease worse. In this study, the authors show that anti-Spike IgG made SARS-CoV disease worse by switching macrophage

Hannah | Hehua Huang

88549439

1/6 Two proposed interventions from Li Taisheng, the director of ID dept. of Peking Union Medical College Hospital; he works on the frontline for #SARSCoV2 and SARSCov11. "Give IV immunoglobulin

TXinTimeOut

TXstillWatching

I brought ccr5-delta32 mutants, -rh blood types, and using ccr5 antagonists as possible treatment back when Pradhan published the "Uncanny similarity of unique inserts in the 2019-nCoV spike protein to

Tyler Larsen

TylerLarsenMD

1/ Does atelectasis cause post-operative fever?I occasionally hear atelectasis listed in the differential diagnosis for early post-op fever (EPF) but this idea has never made much physiologic sense to me.

Phil Yin

YinPD

THREAD 1/15: The 26Mar2020 #MGH grand rounds was an excellent summary of #COVID19 pathogenesis, respiratory management, exploratory therapies, and developing science. Worth listening to in entirety, but summarizing some key