So here's an interesting preprint from @carolilucas, @VirusesImmunity et al serially analysing "immune responses in 113 COVID-19 patients with moderate (non-ICU) and severe (ICU) disease." https://www.medrxiv.org/content/10.1101/2020.06.23.20138289v2

The pathological Th2 immunity scenario recurs:

"Moreover, severe disease was accompanied by an increase in multiple type 2 (anti-helminths) effectors including, IL-5, IL- 13, IgE and eosinophils."

In the non immunological parameters, this is also consistent with what others report
"Body mass index (BMI) was generally increased among patients with severe disease, and extremes in BMI correlated with an increased relative risk of mortality (RR BMI 35: 1.62 [95% CI .81-3.22])"

A core signature

"We observed a “core COVID-19 signature” shared by both moderate and severe groups of patients defined by the following inflammatory cytokines that positively correlated with each other; these include:IL-1α, IL-1β, IL-17A, IL-12 p70, and IFN-α (Fig. 1d)."

But here's why longitudional data is important:
""

"While viral RNA load was not significantly different at any specific time point analysed post symptom onset between severe and moderate patients, moderate patients showed a steady decline in viral load over the course of disease, and severe patients did not (Fig. 3a)"

It should be noted that these viral loads are measured in nasopharyngeal swabs, so loads deeper in the respiratory system or in other organs may show a clearer relationship to severity or to specific immune parameters.

A great dataset to go foraging in, including 9 supplemental figures that now I need to go back and download separately...

Congratulations to all involved, this is a ton of work.