#GWAS

New preprint from @PGCgenetics - PGC3 bipolar disorder (BD) GWAS identifies 64 GW sig loci 2020.09.17.20187054v1 Highlights: 1) >40k cases from European ancestries, 33 novel loci, inflection point (where increase

Something very comforting about the v high reliability and reproducibility of modern GWAS. I believe the first report of an association between SLC2A9 and uric acid and gout is this

Chris Ponting @🏡

Today we announce DecodeME, the world’s largest genetic study into #ME funded by @The_MRC & @NIHRresearch. This project has evolved into a fantastic partnership between people with ME, their carers,

Veera M. Rajagopal

A new trans ethnic GWAS of type 2 diabetes has discovered an interesting locus (TGFB1; OR-1.27) with large effect size comparable to TCF7L2. The MAF of this variant is 0

GWAS of dietary intake: A thread to help interpret our results. All technical details are exhaustively described in our Supplement! https://www.nature.com/articles/s41380-020-0697-5 /1 We studied *relative* intake of carbs, fat, protein,

The last chapter of Xinxin’s thesis is now on @biorxivpreprint. 1/nhttps://twitter.com/biorxivpreprint/status/1297409581342167040 It describes a follow-up to @ClarissaCParker’s GWAS in outbred CFW mice, which identified a locus for meth

The first step in mapping a SNP to a gene is to understand what was measured. "Fibroblastic disorders" is a little vague, but going to the (very nice) PheWeb server

Today is Thanksgiving in the U.S.—in the spirit of the holiday, I want to focus on a positive story about CRISPR, instead of the misadventures of He Jiankui:“How CRISPR +

RxCelerate Limited

Our Research Tissue Bank, held under HTA license, is a magnificent resourced with almost 100,000 blood samples in multiple carefully designed cohortsWhatever your question, it’s likely we can answer it

Clement “I beat COVID19” Chow

New @chowlab paper about #NGLY1 up on @biorxivpreprint! A big effort between postdoc @dana_talsness and grad student @kgowings. With important help from Aylin Rodan & @NathanClark111’s groups at @UofUMedicine &

Survived another ASHG plenary talk :)In case you missed it, I presented results on behalf of @Regeneron from a trans-ancestry #COVID19 meta-analysis of common and rare variants + gene burden

Jonathan Pritchard

Our latest: "GWAS of three molecular traits highlights core genes and pathways alongside a highly polygenic background": https://www.biorxiv.org/content/10.1101/2020.04.20.051631v1 We use urate, IGF-1, and testosterone as model molecular tr

Towards Reproducible Brain-Wide Association Studies https://www.biorxiv.org/content/10.1101/2020.08.21.257758v1 (thread follows...) This is a really interesting and important paper showing that very large samples are required to get reliabl

I saw a press release for this paper, and thought, whoa, those are some provocative claims. Then I read it. It is hard to describe how bad it is. "Evolution

Jonathan Pritchard

How can we systematically measure gene regulatory networks around key disease genes? Excited to share our new work using CRISPR KOs in primary T cells, with @MarsonLab, led by @JakeFreimer

Jonathan Pritchard

Yesterday I ran a thread about our new paper using UK Biobank GWAS to identify core genes for several traits:https://twitter.com/jkpritch/status/1253066314802839552Today I want to expand on some fascinating things that we