Read on Twitter
1/x Platelets Can Associate With SARSCoV2 RNA and Are Hyperactivated in C19 (17/9/2020)
Quoting,
â...HYPERCOAGULATION and THROMBOSIS contribute to lethality of [C19].
Platelets are chiefly implicated in thrombosis.
[platelets] CAN interact with virusesâ https://www.ahajournals.org/doi/full/10.1161/CIRCRESAHA.120.317703
Quoting,
â...HYPERCOAGULATION and THROMBOSIS contribute to lethality of [C19].
Platelets are chiefly implicated in thrombosis.
[platelets] CAN interact with virusesâ https://www.ahajournals.org/doi/full/10.1161/CIRCRESAHA.120.317703
2/x Conât quote,
âplatelets hyperactivated in C19 subjects presenting nonsevere & severe symptoms,
with AGGREGATION occurring at suboptimal #thrombin concentrations
...platelets adhered more efficiently...
Platelets may...contribute to overwhelming THROMBO-INFLAMMATION in C19â
âplatelets hyperactivated in C19 subjects presenting nonsevere & severe symptoms,
with AGGREGATION occurring at suboptimal #thrombin concentrations
...platelets adhered more efficiently...
Platelets may...contribute to overwhelming THROMBO-INFLAMMATION in C19â
3/ Quoting
â[platelets] are an important source of inflammatory mediators.
While a LOWER PLATELET COUNT is associated with severity/mortality, little is known about platelet function during C19.â
Q:
What causes LOWER platelet count
and platelet AGGREGATION
in some C19 patients?
â[platelets] are an important source of inflammatory mediators.
While a LOWER PLATELET COUNT is associated with severity/mortality, little is known about platelet function during C19.â
Q:
What causes LOWER platelet count
and platelet AGGREGATION
in some C19 patients?
4/x Interestingly, can the SAME question be asked for some people with severe adverse reactions,
post-Covid19 VACCINE,
including
-LOWER platelet count
AND
-platelet AGGREGATION (BLOOD CLOTS)?
aka vaccine induced immune thrombotic thrombocytopenia (VITT)? https://www.bmj.com/content/373/bmj.n954
post-Covid19 VACCINE,
including
-LOWER platelet count
AND
-platelet AGGREGATION (BLOOD CLOTS)?
aka vaccine induced immune thrombotic thrombocytopenia (VITT)? https://www.bmj.com/content/373/bmj.n954
5/x In other words, why do SIMILAR severe symptoms including:
- LOW platelets; and
- BLOOD CLOTS
arise in BOTH
- severe Covid-19 patients
AND
- in some people who suffer adverse reactions, post-vaccine?
More to come... https://www.bmj.com/content/373/bmj.n954
- LOW platelets; and
- BLOOD CLOTS
arise in BOTH
- severe Covid-19 patients
AND
- in some people who suffer adverse reactions, post-vaccine?
More to come... https://www.bmj.com/content/373/bmj.n954
6/x Platelets Can Associate With SARS-CoV-2 RNA and Are Hyperactivated in COVID-19
https://www.ahajournals.org/doi/abs/10.1161/CIRCRESAHA.120.317703
https://www.ahajournals.org/doi/abs/10.1161/CIRCRESAHA.120.317703
7/x Another paper
SARS-CoV-2 spike S1 subunit induces hypercoagulability
Quoting
âThe vascular complications of [Covid-19] include a range of various #coagulopathies that cause
BLEEDING
and
THROMBOCYTOPENIA
or a hypercoagulable state.â https://www.google.com.au/amp/s/www.news-medical.net/amp/news/20210310/SARS-CoV-2-spike-S1-subunit-induces-hypercoagulability.aspx
SARS-CoV-2 spike S1 subunit induces hypercoagulability
Quoting
âThe vascular complications of [Covid-19] include a range of various #coagulopathies that cause
BLEEDING
and
THROMBOCYTOPENIA
or a hypercoagulable state.â https://www.google.com.au/amp/s/www.news-medical.net/amp/news/20210310/SARS-CoV-2-spike-S1-subunit-induces-hypercoagulability.aspx
8/ âThe isolated [SARSCoV2 spike]
S1..
Platelet activation
When whole blood was exposed to SPIKE PROTEINS
even at low concentrations,
erythrocytes showed AGGLUTINATION,
HYPERACTIVATED PLATELETS were seen,
with membrane spreading
and formation of platelet-derived microparticlesâ
S1..
Platelet activation
When whole blood was exposed to SPIKE PROTEINS
even at low concentrations,
erythrocytes showed AGGLUTINATION,
HYPERACTIVATED PLATELETS were seen,
with membrane spreading
and formation of platelet-derived microparticlesâ
9/x Conât
âIn all samples, spontaneous amyloid deposits formed after exposure to the SPIKE PROTEIN *without* need for thrombin exposure
..IMPLICATIONS?
..SPIKE S1 not only interacts directly with BOTH
platelets
and with..fibrinogen and.. fibrin,
...alter the way blood clots.â
âIn all samples, spontaneous amyloid deposits formed after exposure to the SPIKE PROTEIN *without* need for thrombin exposure
..IMPLICATIONS?
..SPIKE S1 not only interacts directly with BOTH
platelets
and with..fibrinogen and.. fibrin,
...alter the way blood clots.â
10/x
âExposure to SPIKE PROTEIN PRECIPITATE[D] DENSE CLOTS.
*When SPIKES and thrombin were added to HEALTHY PPP*,
formation of abnormal amyloid deposits INCREASED.
These also showed significant changes in the blood cells' ultrastructure, including the red cells and platelets.â
âExposure to SPIKE PROTEIN PRECIPITATE[D] DENSE CLOTS.
*When SPIKES and thrombin were added to HEALTHY PPP*,
formation of abnormal amyloid deposits INCREASED.
These also showed significant changes in the blood cells' ultrastructure, including the red cells and platelets.â
11/x
â..extensive spontaneous fibrin networks following ADDITION of SPIKE PROTEIN to whole blood
matches
the ultrastructural appearance seen on COVID19-positive blood smears.
..primary features were
anomalous CLOTTING
amyloid in the CLOTS
spontaneous fibrin network formationâ
â..extensive spontaneous fibrin networks following ADDITION of SPIKE PROTEIN to whole blood
matches
the ultrastructural appearance seen on COVID19-positive blood smears.
..primary features were
anomalous CLOTTING
amyloid in the CLOTS
spontaneous fibrin network formationâ
12/x Conât quoting
âit [ie spike protein] may alter blood flow in COVID19.
The microfluidics simulation showed that the PPP from COVID-19 patients, which is almost pure fibrinogen,
formed LARGE OBSTRUCTING CLOTS.
"We suggest that, in part,...â >
âit [ie spike protein] may alter blood flow in COVID19.
The microfluidics simulation showed that the PPP from COVID-19 patients, which is almost pure fibrinogen,
formed LARGE OBSTRUCTING CLOTS.
"We suggest that, in part,...â >
13/x Conât quoting
âTHE PRESENCE OF SPIKE PROTEIN in [blood] circulation may contribute to the
HYPERCOAGULATION in COVID-19 ..patients
AND may cause severe impairment of fibrinolysis.
Such lytic impairment may be the direct cause of the LARGE MICROCLOTS we have noted hereâ
âTHE PRESENCE OF SPIKE PROTEIN in [blood] circulation may contribute to the
HYPERCOAGULATION in COVID-19 ..patients
AND may cause severe impairment of fibrinolysis.
Such lytic impairment may be the direct cause of the LARGE MICROCLOTS we have noted hereâ
14/x Conât quoting
âThus, the free S1 subunit has harmful effects on the host even without direct infection of the cells themselves.â
SOURCE:
SARS-CoV-2 spike S1 subunit induces hypercoagulability https://www.google.com.au/amp/s/www.news-medical.net/amp/news/20210310/SARS-CoV-2-spike-S1-subunit-induces-hypercoagulability.aspx
âThus, the free S1 subunit has harmful effects on the host even without direct infection of the cells themselves.â
SOURCE:
SARS-CoV-2 spike S1 subunit induces hypercoagulability https://www.google.com.au/amp/s/www.news-medical.net/amp/news/20210310/SARS-CoV-2-spike-S1-subunit-induces-hypercoagulability.aspx
15/x
Question
I wonder whether the Covid19 vax-induced SARSCOV2 spike protein can exert similar effects in some people who suffer vaccine induced immune thrombotic thrombocytopenia (VITT),
given that vax-induced spike protein is identical to that in SARSCOV2 that causes Covid19?
Question
I wonder whether the Covid19 vax-induced SARSCOV2 spike protein can exert similar effects in some people who suffer vaccine induced immune thrombotic thrombocytopenia (VITT),
given that vax-induced spike protein is identical to that in SARSCOV2 that causes Covid19?
16/x Another great article by Dr @sebrushworth
Is the Astra-Zeneca vaccine killing people?
https://sebastianrushworth.com/2021/04/17/is-the-astra-zeneca-vaccine-killing-people/
Is the Astra-Zeneca vaccine killing people?
https://sebastianrushworth.com/2021/04/17/is-the-astra-zeneca-vaccine-killing-people/
16.1/x Is the Astra-Zeneca vaccine killing people? https://sebastianrushworth.com/2021/04/17/is-the-astra-zeneca-vaccine-killing-people/
17/x SARS-CoV-2 VaccineâInduced Immune Thrombotic Thrombocytopenia
Quoting,
â... cases of immune #thrombocytopenia and BLEEDING without thrombosis that were induced or revealed after ... mRNA... vaccines produced by Moderna ...and Pfizer ...reportedâ https://www.nejm.org/doi/full/10.1056/NEJMe2106315
Quoting,
â... cases of immune #thrombocytopenia and BLEEDING without thrombosis that were induced or revealed after ... mRNA... vaccines produced by Moderna ...and Pfizer ...reportedâ https://www.nejm.org/doi/full/10.1056/NEJMe2106315
17.1/x Conât Quoting
â39 persons with.. #thrombosis and #thrombocytopenia ... 5 to 24 days AFTER initial vaccination with ... #AstraZeneca,
a recombinant #chimpanzee adenoviral vector encoding SPIKE PROTEIN..
HEALTHY or in medically stable condition..
Most..were women <50 yearsâ
â39 persons with.. #thrombosis and #thrombocytopenia ... 5 to 24 days AFTER initial vaccination with ... #AstraZeneca,
a recombinant #chimpanzee adenoviral vector encoding SPIKE PROTEIN..
HEALTHY or in medically stable condition..
Most..were women <50 yearsâ
17.2/x Conât Quoting
âA remarkably high % of patients had #thromboses at unusual sites â specifically, CEREBRAL VENOUS SINUS THROMBOSIS or THROMBOSIS in portal, splanchnic, or hepatic veins.
Others..presented
-DEEP VENOUS THROMBI
-PULMONARY EMBOLI
-ACUTE ARTERIAL THROMBOSESâ
âA remarkably high % of patients had #thromboses at unusual sites â specifically, CEREBRAL VENOUS SINUS THROMBOSIS or THROMBOSIS in portal, splanchnic, or hepatic veins.
Others..presented
-DEEP VENOUS THROMBI
-PULMONARY EMBOLI
-ACUTE ARTERIAL THROMBOSESâ
17.3/x Conât quoting
âThe median platelet counts at diagnosis were ~20,000 to 30,000 per cubic millimeter (range, ~10,000 to 110,000)...
High levels of d-dimers and low levels of fibrinogen were common and suggest SYSTEMIC activation of COAGULATION.
~40% of the patients DIEDâ
âThe median platelet counts at diagnosis were ~20,000 to 30,000 per cubic millimeter (range, ~10,000 to 110,000)...
High levels of d-dimers and low levels of fibrinogen were common and suggest SYSTEMIC activation of COAGULATION.
~40% of the patients DIEDâ
17.4/x Conât quoting
âsome [DIED] from
-ischemic brain injury
-superimposed hemorrhage,
or
-both conditions, often after anticoagulation.
... the pathogenesis of this syndrome of vaccine-induced immune thrombotic thrombocytopenia (VITT) is not yet clear...â
âsome [DIED] from
-ischemic brain injury
-superimposed hemorrhage,
or
-both conditions, often after anticoagulation.
... the pathogenesis of this syndrome of vaccine-induced immune thrombotic thrombocytopenia (VITT) is not yet clear...â
17.5/ Conât quote
â169 [cases] cerebral venous sinus #thrombosis
53 [cases] splanchnic vein #thrombosis...[AstraZeneca]
35 [cases] CNS #thrombosis ...Pfizer..
5 [cases] cerebral venous sinus #thrombosis...Moderna..
...these numbers may be #underestimates..reporting voluntaryâ
â169 [cases] cerebral venous sinus #thrombosis
53 [cases] splanchnic vein #thrombosis...[AstraZeneca]
35 [cases] CNS #thrombosis ...Pfizer..
5 [cases] cerebral venous sinus #thrombosis...Moderna..
...these numbers may be #underestimates..reporting voluntaryâ
17.6/x SOURCE
SARS-CoV-2 VaccineâInduced Immune Thrombotic Thrombocytopenia https://www.nejm.org/doi/full/10.1056/NEJMe2106315
SARS-CoV-2 VaccineâInduced Immune Thrombotic Thrombocytopenia https://www.nejm.org/doi/full/10.1056/NEJMe2106315
17.7/x Quoting more
âIn almost every patient, HIGH levels of antibodies to platelet factor 4 ( #PF4)âpolyanion complexes were identified ...â
This is interesting because ... >
âIn almost every patient, HIGH levels of antibodies to platelet factor 4 ( #PF4)âpolyanion complexes were identified ...â
This is interesting because ... >
17.8/x
âIn contrast to heparin-induced thrombocytopenia,
however,
binding of antibody to #PF4 occurred in ABSENCE OF HEPARIN.â
Guess what?
This may ALSO occur in C19!
Platelet-activating immune complexes identified in critically ill C19 patients... https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8014456/
âIn contrast to heparin-induced thrombocytopenia,
however,
binding of antibody to #PF4 occurred in ABSENCE OF HEPARIN.â
Guess what?
This may ALSO occur in C19!
Platelet-activating immune complexes identified in critically ill C19 patients... https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8014456/
17.9/x
Quoting Results,
â6 critically ill COVIDâ19 samples demonstrated significant platelet activation in the ABSENCE OF HEPARIN ...
All 6 plateletâactivating samples contained
**IgGâspecific antibodies against [receptor binding domain], SPIKE [protein], or both proteins...**â
Quoting Results,
â6 critically ill COVIDâ19 samples demonstrated significant platelet activation in the ABSENCE OF HEPARIN ...
All 6 plateletâactivating samples contained
**IgGâspecific antibodies against [receptor binding domain], SPIKE [protein], or both proteins...**â
17.10/x Conât quoting
âA subset of critically ill COVIDâ19 patient sera thus contains ICs [immune complexes] that mediate platelet activation via FcÎłRIIA signalling
..
The lack of antiâPF4/heparin antibodies and presence of heparinâINDEPENDENT serotonin release assay activationâ
âA subset of critically ill COVIDâ19 patient sera thus contains ICs [immune complexes] that mediate platelet activation via FcÎłRIIA signalling
..
The lack of antiâPF4/heparin antibodies and presence of heparinâINDEPENDENT serotonin release assay activationâ
17.11/x Conât
â...strongly RULES OUT heparin-induced thrombocytopenia
..
certain critically ill COVIDâ19 patients feature a novel IC [immune complex]-mediated THROMBOTIC MICROANGIOPATHY ..SIGNIFICANT PLATELET ACTIVATION.
..highly #prothrombotic
..with unique plateletâactivatingâ
â...strongly RULES OUT heparin-induced thrombocytopenia
..
certain critically ill COVIDâ19 patients feature a novel IC [immune complex]-mediated THROMBOTIC MICROANGIOPATHY ..SIGNIFICANT PLATELET ACTIVATION.
..highly #prothrombotic
..with unique plateletâactivatingâ
As noted in 17.9/x above,
âAll 6 plateletâactivating samples [from 6 critically ill, NON-vaccinated C19 patients] contained
*IgGâspecific antibodies AGAINST:
- the receptor binding domain
- SPIKE [PROTEIN]
or
- BOTH proteins of the SARSCOV2 virus.*â
âAll 6 plateletâactivating samples [from 6 critically ill, NON-vaccinated C19 patients] contained
*IgGâspecific antibodies AGAINST:
- the receptor binding domain
- SPIKE [PROTEIN]
or
- BOTH proteins of the SARSCOV2 virus.*â
17.13/x
To repeat from 17.11/x,
âThese 6 critically ill, NON-vaccinated COVIDâ19 patients feature a novel immune complex-mediated THROMBOTIC MICROANGIOPATHY [with] SIGNIFICANT PLATELET ACTIVATION.
..highly #prothrombotic
..with unique plateletâactivating...â
To repeat from 17.11/x,
âThese 6 critically ill, NON-vaccinated COVIDâ19 patients feature a novel immune complex-mediated THROMBOTIC MICROANGIOPATHY [with] SIGNIFICANT PLATELET ACTIVATION.
..highly #prothrombotic
..with unique plateletâactivating...â
17.14/x
The $64 Question:
How is this any different from the observed adverse effects of #AstraZeneca and other SARSCOV2 spike protein-inducing experimental mRNA/DNA vaccines?????
The $64 Question:
How is this any different from the observed adverse effects of #AstraZeneca and other SARSCOV2 spike protein-inducing experimental mRNA/DNA vaccines?????
17.15/x
Q2:
Why do #thrombocytopenia and #thrombosis feature in BOTH:
-COVID-19, particularly among critically ill patients (as noted in THIS paper)
AND
-In some #vaccinated
patients, post-experimental mRNA/DNA vaccination? https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8014456/
Q2:
Why do #thrombocytopenia and #thrombosis feature in BOTH:
-COVID-19, particularly among critically ill patients (as noted in THIS paper)
AND
-In some #vaccinated
patients, post-experimental mRNA/DNA vaccination? https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8014456/
18/x The point i am trying to make:
-severe Covid symptoms in certain critically-ill, *unvaccinated* C19 patients (whose symptoms arise for complex reasons - NOT just Covid)
s/be compared and contrasted with
-severe adverse effects that arise in some healthy people, post-vax >
-severe Covid symptoms in certain critically-ill, *unvaccinated* C19 patients (whose symptoms arise for complex reasons - NOT just Covid)
s/be compared and contrasted with
-severe adverse effects that arise in some healthy people, post-vax >
18.1/x Thus, questions s/be asked:
Q1:
Were it not for vaccine, would many young, healthy people who suffered adverse effects, post-vax, STILL have suffered THESE SAME adverse effects as those suffered by critically-ill, unvaccinated Covid19 patients?? https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3266166/
Q1:
Were it not for vaccine, would many young, healthy people who suffered adverse effects, post-vax, STILL have suffered THESE SAME adverse effects as those suffered by critically-ill, unvaccinated Covid19 patients?? https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3266166/
18.3/
Q2:
What is common denominator between 1st group (likely, with comorbidities) and 2nd?
Could immune system of vaxâd ppl react
due to partial #homology between vax-induced spike and certain human molecules (self)?
If so, could #molecularmimicry trigger autoimmune disease?
Q2:
What is common denominator between 1st group (likely, with comorbidities) and 2nd?
Could immune system of vaxâd ppl react
due to partial #homology between vax-induced spike and certain human molecules (self)?
If so, could #molecularmimicry trigger autoimmune disease?
18.4/x An example of molecular mimicry
https://twitter.com/My2puppies1/status/1384377949890088960?s=20
https://twitter.com/My2puppies1/status/1384377949890088960?s=20
19/x i will discuss this paper soon:
For now, fasten your seatbelts
Reaction of Human Monoclonal Antibodies to SARS-CoV-2 Proteins With Tissue Antigens: Implications for Autoimmune Diseases https://www.frontiersin.org/articles/10.3389/fimmu.2020.617089/full?s=03
For now, fasten your seatbelts
Reaction of Human Monoclonal Antibodies to SARS-CoV-2 Proteins With Tissue Antigens: Implications for Autoimmune Diseases https://www.frontiersin.org/articles/10.3389/fimmu.2020.617089/full?s=03
19.1/ Before looking at above, letâs look here
#MolecularMimicry between SARSCoV2 SPIKE glycoprotein and mammalian PROTEOMES:
implications for vax
Quote
â..MASSIVE heptapeptide SHARING exists between:
- SARSCoV2 spike glycoprotein
AND
- human proteinsâ https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7499017/#!po=1.78571
#MolecularMimicry between SARSCoV2 SPIKE glycoprotein and mammalian PROTEOMES:
implications for vax
Quote
â..MASSIVE heptapeptide SHARING exists between:
- SARSCoV2 spike glycoprotein
AND
- human proteinsâ https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7499017/#!po=1.78571
19.2/x conât quoting
âSuch peptide COMMONALITY is UNEXPECTED
and HIGHLY #IMPROBABLE from a mathematical point of view...
This study thoroughly quantifies the ... peptide SHARING of SARS-CoV-2 spike glycoprotein-
a major antigen of the virus-
with mammalian proteomes.â
âSuch peptide COMMONALITY is UNEXPECTED
and HIGHLY #IMPROBABLE from a mathematical point of view...
This study thoroughly quantifies the ... peptide SHARING of SARS-CoV-2 spike glycoprotein-
a major antigen of the virus-
with mammalian proteomes.â
19.3/x conât
âMASSIVE peptide COMMONALITY is present with HUMANS ... that undergo pathologic consequences following SARSCoV2 infection.
... INDISPUTABLE PROOF IN FAVOR OF #MolecularMimicry as a potential mechanism that can contribute to or cause SARSCoV2 associated diseases.â
âMASSIVE peptide COMMONALITY is present with HUMANS ... that undergo pathologic consequences following SARSCoV2 infection.
... INDISPUTABLE PROOF IN FAVOR OF #MolecularMimicry as a potential mechanism that can contribute to or cause SARSCoV2 associated diseases.â
19.4/x
Q: Given that MASSIVE peptide commonality exists, how can one be 100% certain that PCR test will ONLY confirm presence of SARSCOV2 spike protein,
and NOT the presence of aforementioned human proteins for which MASSIVE heptapeptide SHARING exists due to #MolecularMimicry?
Q: Given that MASSIVE peptide commonality exists, how can one be 100% certain that PCR test will ONLY confirm presence of SARSCOV2 spike protein,
and NOT the presence of aforementioned human proteins for which MASSIVE heptapeptide SHARING exists due to #MolecularMimicry?
19.5/x Here:
âSARSCoV2 RNA reverse-transcribed and integrated into human genome
â...*SARSCoV2 RNAs* can be reverse-transcribed and integrated into the human genome and that transcription of the integrated sequences
MIGHT ACCOUNT FOR PCR-POSITIVE TESTS.â https://pubmed.ncbi.nlm.nih.gov/33330870/
âSARSCoV2 RNA reverse-transcribed and integrated into human genome
â...*SARSCoV2 RNAs* can be reverse-transcribed and integrated into the human genome and that transcription of the integrated sequences
MIGHT ACCOUNT FOR PCR-POSITIVE TESTS.â https://pubmed.ncbi.nlm.nih.gov/33330870/
19.6/x Conât quote
âThis..may explain why patients can continue to produce viral *RNA* [LONG] AFTER RECOVERY..â
NB Viral *RNA* does *NOT* equate to actual virus!
Given that these particular PCR-POSITIVE TESTS DO NOT pertain to infectious or presymp people, they are NOT âCASESâ
âThis..may explain why patients can continue to produce viral *RNA* [LONG] AFTER RECOVERY..â
NB Viral *RNA* does *NOT* equate to actual virus!
Given that these particular PCR-POSITIVE TESTS DO NOT pertain to infectious or presymp people, they are NOT âCASESâ
20/x More on #molecularmimicry
Potential antigenic cross-reactivity between SARSCoV2 and human tissue ..possible link to an INCREASE in #autoimmune diseases
â we tested 5 different blood specimens that were..positive for SARSCoV2 IgG and IgM antibodiesâ https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7246018/
Potential antigenic cross-reactivity between SARSCoV2 and human tissue ..possible link to an INCREASE in #autoimmune diseases
â we tested 5 different blood specimens that were..positive for SARSCoV2 IgG and IgM antibodiesâ https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7246018/
20.1/x
âtested...for
-anti-nuclear antibody (ANA)
-anti-extractable nuclear antigen (ENA)
-anti-double-stranded DNA (dsDNA)
-actin antibody
-mitochondrial antibody
-rheumatoid factor (RF)
-C1q immune complexes.
..surprised to find 3 of 5 specimens had significant ELEVATIONS inâ
âtested...for
-anti-nuclear antibody (ANA)
-anti-extractable nuclear antigen (ENA)
-anti-double-stranded DNA (dsDNA)
-actin antibody
-mitochondrial antibody
-rheumatoid factor (RF)
-C1q immune complexes.
..surprised to find 3 of 5 specimens had significant ELEVATIONS inâ
20.2/x
â- ANA
- ENA
- actin
- mitochondrial antibodies
but not against dsDNA or RF.
[Are there] patterns of #cross-reactivity between SARS-CoV-2 and autoimmune target proteins[?]
Vaccine-induced autoimmunity from autoimmune cross-reactivity is associated with: â
â- ANA
- ENA
- actin
- mitochondrial antibodies
but not against dsDNA or RF.
[Are there] patterns of #cross-reactivity between SARS-CoV-2 and autoimmune target proteins[?]
Vaccine-induced autoimmunity from autoimmune cross-reactivity is associated with: â
20.3/x Quoting
â-narcolepsy
-Guillain-BarrĂŠ syndrome
-MS
-demyelinating neuropathies
-systemic lupus erythematosus
-postural orthostatic tachycardia syndrome
in susceptible subgroups..
we studied relationships between SPIKE and nuclear PROTEINS...and autoimmune target proteinsâ
â-narcolepsy
-Guillain-BarrĂŠ syndrome
-MS
-demyelinating neuropathies
-systemic lupus erythematosus
-postural orthostatic tachycardia syndrome
in susceptible subgroups..
we studied relationships between SPIKE and nuclear PROTEINS...and autoimmune target proteinsâ
20.4/x Quote
âThe virus can in fact affect the body from head to toe including
- nervous
- cardiovascular
- immune
- digestive systems
Is it possible that some of extensive organ, tissue, and cellular damage done by SARSCoV2 is due to VIRAL ANTIGENIC MIMICRY with human tissueâ
âThe virus can in fact affect the body from head to toe including
- nervous
- cardiovascular
- immune
- digestive systems
Is it possible that some of extensive organ, tissue, and cellular damage done by SARSCoV2 is due to VIRAL ANTIGENIC MIMICRY with human tissueâ
20.5/x
Q:
IF (quoting) âsome of extensive organ, tissue, and cellular damage done by SARSCoV2 is due to VIRAL ANTIGENIC MIMICRY with human tissueâ,
wouldnât it be in the realms of possibility that the VACCINE-INDUCED Spike Protein would ALSO induce the aforementioned?
Q:
IF (quoting) âsome of extensive organ, tissue, and cellular damage done by SARSCoV2 is due to VIRAL ANTIGENIC MIMICRY with human tissueâ,
wouldnât it be in the realms of possibility that the VACCINE-INDUCED Spike Protein would ALSO induce the aforementioned?
20.6/x Conât
â..the SARS-CoV-2 SPIKE glycoprotein
AND
lung surfactant proteins
SHARED 13 out of 24 pentapeptides..
immune response following infection with SARS-CoV-2 may lead to
CROSS-REACTIONS WITH
pulmonary surfactant proteins,
followed by SARS-CoV-2-associated lung diseaseâ
â..the SARS-CoV-2 SPIKE glycoprotein
AND
lung surfactant proteins
SHARED 13 out of 24 pentapeptides..
immune response following infection with SARS-CoV-2 may lead to
CROSS-REACTIONS WITH
pulmonary surfactant proteins,
followed by SARS-CoV-2-associated lung diseaseâ
20.7/x
âthey warned AGAINST the use of the ENTIRE SARS-CoV-2 ANTIGENS [eg mRNA for SPIKE PROTEIN] in the vaccines...
we feel that our own findings that 21 of 50 tissue antigens had moderate to strong REACTIONS with SARS-CoV-2 antibodies are a sufficiently strong indication ofâ
âthey warned AGAINST the use of the ENTIRE SARS-CoV-2 ANTIGENS [eg mRNA for SPIKE PROTEIN] in the vaccines...
we feel that our own findings that 21 of 50 tissue antigens had moderate to strong REACTIONS with SARS-CoV-2 antibodies are a sufficiently strong indication ofâ
20.8/x
âstrong indication of CROSS-REACTION between
- SARS-CoV-2 proteins [eg SPIKE]
AND
- a variety of tissue antigens beyond just pulmonary tissue
which could lead to autoimmunity against
- connective tissue
- cardiovascular system
- gastrointestinal system
- nervous system.â
âstrong indication of CROSS-REACTION between
- SARS-CoV-2 proteins [eg SPIKE]
AND
- a variety of tissue antigens beyond just pulmonary tissue
which could lead to autoimmunity against
- connective tissue
- cardiovascular system
- gastrointestinal system
- nervous system.â
20.9/x Conât quoting
âWe must consider that finding a vaccine for a disease may normally take YEARS [!!].
There are reasons for all the precautions involved in developing a vaccine, not the least of which are UNWANTED side-effects.
In light of information discussed above ..â >
âWe must consider that finding a vaccine for a disease may normally take YEARS [!!].
There are reasons for all the precautions involved in developing a vaccine, not the least of which are UNWANTED side-effects.
In light of information discussed above ..â >
20.10/x Conât quoting
âabout the CROSS-REACTIVITY of the SARS-CoV-2 proteins [eg SPIKE]
with
human tissues
AND
the possibility of either:
- inducing autoimmunity,
- exacerbating already unhealthy conditions, or
- otherwise resulting in unforeseen consequences, ..â
âabout the CROSS-REACTIVITY of the SARS-CoV-2 proteins [eg SPIKE]
with
human tissues
AND
the possibility of either:
- inducing autoimmunity,
- exacerbating already unhealthy conditions, or
- otherwise resulting in unforeseen consequences, ..â
20.11/x
âit would only be PRUDENT TO DO MORE EXTENSIVE RESEARCH regarding the autoimmune-inducing capacity of the SARS-CoV-2 antigens [including the SPIKE].
The promotion and implementation of such an ***AGGRESSIVE âimmune passportâ program worldwide***
in the ABSENCE of..â
âit would only be PRUDENT TO DO MORE EXTENSIVE RESEARCH regarding the autoimmune-inducing capacity of the SARS-CoV-2 antigens [including the SPIKE].
The promotion and implementation of such an ***AGGRESSIVE âimmune passportâ program worldwide***
in the ABSENCE of..â
20.12/x Conât quoting
â..in ABSENCE of thorough and meticulous safety studies may exact a MONUMENTAL COST ON HUMANITY in the form of ANOTHER epidemic,
this time a rising tide of INCREASED #autoimmune diseases and YEARS OF SUFFERING that come with themâ
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7246018/
â..in ABSENCE of thorough and meticulous safety studies may exact a MONUMENTAL COST ON HUMANITY in the form of ANOTHER epidemic,
this time a rising tide of INCREASED #autoimmune diseases and YEARS OF SUFFERING that come with themâ
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7246018/
20.13/x
Re-quoting 20.7/x & 20.8/x
â...our own findings that 21 of 50 tissue antigens had moderate to strong REACTIONS with SARS-CoV-2 antibodies are a sufficiently strong indication of CROSS-REACTION between
- SARS-CoV-2 proteins [eg SPIKE]
AND
- a VARIETY of tissue antigens..â
Re-quoting 20.7/x & 20.8/x
â...our own findings that 21 of 50 tissue antigens had moderate to strong REACTIONS with SARS-CoV-2 antibodies are a sufficiently strong indication of CROSS-REACTION between
- SARS-CoV-2 proteins [eg SPIKE]
AND
- a VARIETY of tissue antigens..â
20.14/x
Q:
Due to this aforementioned *CROSS-REACTIVITY*,
how can one be 100% certain that PCR test ALSO does NOT (inadvertently) test positive for the presence of one or more of these aforementioned TISSUE ANTIGENS
(in addition to, or instead of, the SARSCOV2 Spike Protein)?
Q:
Due to this aforementioned *CROSS-REACTIVITY*,
how can one be 100% certain that PCR test ALSO does NOT (inadvertently) test positive for the presence of one or more of these aforementioned TISSUE ANTIGENS
(in addition to, or instead of, the SARSCOV2 Spike Protein)?
21/x Another paper
#PathogenicPriming likely contributes to SERIOUS and CRITICAL ILLNESS and MORTALITY in COVID-19 via #AUTOIMMUNITY
Quoting
⢠ALL SARS-CoV-2 immunogenic #epitopes have SIMILARITY to HUMAN PROTEINS - except one. https://www.sciencedirect.com/science/article/pii/S2589909020300186?via%3Dihub
#PathogenicPriming likely contributes to SERIOUS and CRITICAL ILLNESS and MORTALITY in COVID-19 via #AUTOIMMUNITY
Quoting
⢠ALL SARS-CoV-2 immunogenic #epitopes have SIMILARITY to HUMAN PROTEINS - except one. https://www.sciencedirect.com/science/article/pii/S2589909020300186?via%3Dihub
21.1/
â
⢠[~1/3] of the potentially targeted human proteins (putative autoantigens) are KEY PLAYERS IN THE ADAPTIVE IMMUNE SYSTEM
⢠The list of viral/human protein matches provides CLUES on which (parts of) #epitopes might be involved in the immunopathogenesis of COVID-19...â
â
⢠[~1/3] of the potentially targeted human proteins (putative autoantigens) are KEY PLAYERS IN THE ADAPTIVE IMMUNE SYSTEM
⢠The list of viral/human protein matches provides CLUES on which (parts of) #epitopes might be involved in the immunopathogenesis of COVID-19...â
21.2/
â
⢠..indicates which #epitopes might be responsible for #autoimmunological #PathogenicPriming ..following exposure to SARS-CoV-2 or relatives FOLLOWING vax
⢠These #epitopes SHOULD BE EXCLUDED from #vaccines ...to MINIMISE autoimmunity due to RISK of pathogenic primingâ
â
⢠..indicates which #epitopes might be responsible for #autoimmunological #PathogenicPriming ..following exposure to SARS-CoV-2 or relatives FOLLOWING vax
⢠These #epitopes SHOULD BE EXCLUDED from #vaccines ...to MINIMISE autoimmunity due to RISK of pathogenic primingâ
21.3/x
âHOMOLOGY between:
⢠HUMAN [proteins]
and
⢠VIRAL proteins
is an established factor in viral- [natural-] or vaccine-induced autoimmunity. ..
Immunogenic peptides in viruses or bacteria that MATCH human proteins are good candidates for pathogenic priming peptides ..â
âHOMOLOGY between:
⢠HUMAN [proteins]
and
⢠VIRAL proteins
is an established factor in viral- [natural-] or vaccine-induced autoimmunity. ..
Immunogenic peptides in viruses or bacteria that MATCH human proteins are good candidates for pathogenic priming peptides ..â
21.4/x Quoting
âSAR-CoV-2 SPIKE proteins ... immunogenic #epitopes in each SARS-CoV-2 protein were compared to HUMAN proteins -
in search of HIGH local #homologous matching.
ONLY ONE immunogenic epitope in a SARS-CoV-2 had NO homology to human proteins.â
âSAR-CoV-2 SPIKE proteins ... immunogenic #epitopes in each SARS-CoV-2 protein were compared to HUMAN proteins -
in search of HIGH local #homologous matching.
ONLY ONE immunogenic epitope in a SARS-CoV-2 had NO homology to human proteins.â
21.5/x Quoting
âMapping of the genes encoding human protein ...point to targets that could explain ...[C19] symptoms..
..
SARS-CoV-2 virus has numerous OTHER proteins and polyproteins,
each which may serve as an ANTIGEN SOURCE during infection
leading to #autoimmunity.â
âMapping of the genes encoding human protein ...point to targets that could explain ...[C19] symptoms..
..
SARS-CoV-2 virus has numerous OTHER proteins and polyproteins,
each which may serve as an ANTIGEN SOURCE during infection
leading to #autoimmunity.â
21.6/x Quoting
âResults
37 SARS-CoV-2 proteins were downloaded from the NCBI SARS-CoV-2 NCBI resource.
Of these, 8 proteins had no recognizably immunogenic peptides.
The remaining [29] proteins had [1 to 6] immunogenic peptides (Table 1).â
![21.6/x QuotingâResults37 SARS-CoV-2 proteins were downloaded from the NCBI SARS-CoV-2 NCBI resource.Of these, 8 proteins had no recognizably immunogenic peptides.The remaining [29] proteins had [1 to 6] immunogenic peptides (Table 1).â](https://pbs.twimg.com/media/Ez1Y6yrUcAAjBg5.jpg "21.6/x QuotingâResults37 SARS-CoV-2 proteins were downloaded from the NCBI SARS-CoV-2 NCBI resource.Of these, 8 proteins had no recognizably immunogenic peptides.The remaining [29] proteins had [1 to 6] immunogenic peptides (Table 1).â")
![21.6/x QuotingâResults37 SARS-CoV-2 proteins were downloaded from the NCBI SARS-CoV-2 NCBI resource.Of these, 8 proteins had no recognizably immunogenic peptides.The remaining [29] proteins had [1 to 6] immunogenic peptides (Table 1).â](https://pbs.twimg.com/media/Ez1ZD3YVUAQBxDG.jpg "21.6/x QuotingâResults37 SARS-CoV-2 proteins were downloaded from the NCBI SARS-CoV-2 NCBI resource.Of these, 8 proteins had no recognizably immunogenic peptides.The remaining [29] proteins had [1 to 6] immunogenic peptides (Table 1).â")
![21.6/x QuotingâResults37 SARS-CoV-2 proteins were downloaded from the NCBI SARS-CoV-2 NCBI resource.Of these, 8 proteins had no recognizably immunogenic peptides.The remaining [29] proteins had [1 to 6] immunogenic peptides (Table 1).â](https://pbs.twimg.com/media/Ez1ZHJ1VgAQkcDd.jpg "21.6/x QuotingâResults37 SARS-CoV-2 proteins were downloaded from the NCBI SARS-CoV-2 NCBI resource.Of these, 8 proteins had no recognizably immunogenic peptides.The remaining [29] proteins had [1 to 6] immunogenic peptides (Table 1).â")
âResults
37 SARS-CoV-2 proteins were downloaded from the NCBI SARS-CoV-2 NCBI resource.
Of these, 8 proteins had no recognizably immunogenic peptides.
The remaining [29] proteins had [1 to 6] immunogenic peptides (Table 1).â
21.7/x
âThe proteins with the largest number of immunogenic peptides were the Spike,
or S protein (N â= â6 in total),
and..
All of the [SARSCOV2 proteins; ie immunogenic #epitopes] had at least ONE MATCH to human proteins -
except one..â
âThe proteins with the largest number of immunogenic peptides were the Spike,
or S protein (N â= â6 in total),
and..
All of the [SARSCOV2 proteins; ie immunogenic #epitopes] had at least ONE MATCH to human proteins -
except one..â
21.8/
âRemarkably, over 1/3 (11/27) of immunogenic proteins in SARS-CoV-2 have potentially PROBLEMATIC HOMOLOGY to proteins that are key to the human #adaptive immune system (emboldened in Table 1)
SARS-CoV-2 [including vax-induced SPIKE] could impair immune response, at firstâ
âRemarkably, over 1/3 (11/27) of immunogenic proteins in SARS-CoV-2 have potentially PROBLEMATIC HOMOLOGY to proteins that are key to the human #adaptive immune system (emboldened in Table 1)
SARS-CoV-2 [including vax-induced SPIKE] could impair immune response, at firstâ
21.9/
âand then, over time, the immune system could begin to mount an attack on myriad of [human] proteins.
Most of..human target proteins had low overall homology but HIGH LOCAL HOMOLOGY OVER SHORT SEGMENTS OF THEIR EPITOPES.
.. numerous proteins expressed in [human] tissuesâ
âand then, over time, the immune system could begin to mount an attack on myriad of [human] proteins.
Most of..human target proteins had low overall homology but HIGH LOCAL HOMOLOGY OVER SHORT SEGMENTS OF THEIR EPITOPES.
.. numerous proteins expressed in [human] tissuesâ
21.10/
âNo vax against SARSCoV2 has yet been tested in ANIMALS
and therefore we do NOT yet know if #pathogenicpriming is expected.
Such studies S/BE undertaken *BEFORE* USE OF ANY VACCINE against SARS-CoV-2 is used in HUMANS.â
Q
Where are these studies? https://www.sciencedirect.com/science/article/pii/S2589909020300186?via%3Dihub
âNo vax against SARSCoV2 has yet been tested in ANIMALS
and therefore we do NOT yet know if #pathogenicpriming is expected.
Such studies S/BE undertaken *BEFORE* USE OF ANY VACCINE against SARS-CoV-2 is used in HUMANS.â
Q
Where are these studies? https://www.sciencedirect.com/science/article/pii/S2589909020300186?via%3Dihub
22/x Another paper
SARS-CoV-2 Spike Protein Elicits Cell Signaling in Human Host Cells: Implications for Possible Consequences of COVID-19 Vaccines https://www.mdpi.com/2076-393X/9/1/36/htm
SARS-CoV-2 Spike Protein Elicits Cell Signaling in Human Host Cells: Implications for Possible Consequences of COVID-19 Vaccines https://www.mdpi.com/2076-393X/9/1/36/htm
22.1/x
to https://twitter.com/CaudeHenrion/status/1385957173184897025?s=20 https://twitter.com/SabinaWalker18/status/1386251505263542282?s=20
to https://twitter.com/CaudeHenrion/status/1385957173184897025?s=20 https://twitter.com/SabinaWalker18/status/1386251505263542282?s=20
23/x Letâs look at this paper https://twitter.com/SabinaWalker18/status/1384454468314419204?s=20
23.1/x
Reaction of Human Monoclonal Antibodies to SARSCoV2 Proteins With Tissue Antigens: Implications for #AutoimmuneDiseases (19/1/21)
Quoting
â[Does] immune reactivity occur between
⢠anti-SARSCoV2 protein ANTIBODIES
and
⢠human tissue ANTIGENS[?]â https://www.frontiersin.org/articles/10.3389/fimmu.2020.617089/full?s=03
Reaction of Human Monoclonal Antibodies to SARSCoV2 Proteins With Tissue Antigens: Implications for #AutoimmuneDiseases (19/1/21)
Quoting
â[Does] immune reactivity occur between
⢠anti-SARSCoV2 protein ANTIBODIES
and
⢠human tissue ANTIGENS[?]â https://www.frontiersin.org/articles/10.3389/fimmu.2020.617089/full?s=03
23.2/x Cont quote
â[If yes, could] #MolecularMimicry between...viral proteins [including SPIKE protein] and human tissues ... be the cause[?]â
Added:
Remember that ANTIBODIES may arise:
⢠after natural infection
AND
⢠after mRNA/DNA vax that induces the SARSCOV2 SPIKE protein
â[If yes, could] #MolecularMimicry between...viral proteins [including SPIKE protein] and human tissues ... be the cause[?]â
Added:
Remember that ANTIBODIES may arise:
⢠after natural infection
AND
⢠after mRNA/DNA vax that induces the SARSCOV2 SPIKE protein
23.3/x Conât quoting,
âWe applied both:
⢠human MONOCLONAL anti-SARSCov2 antibodies (SPIKE protein, nucleoprotein)
and
⢠rabbit polyclonal anti-SARSCov2 antibodies (envelope protein, membrane protein)
to 55 different TISSUE ANTIGENS.â
âWe applied both:
⢠human MONOCLONAL anti-SARSCov2 antibodies (SPIKE protein, nucleoprotein)
and
⢠rabbit polyclonal anti-SARSCov2 antibodies (envelope protein, membrane protein)
to 55 different TISSUE ANTIGENS.â
23.4/x Conât quoting,
â...SARSCoV2 antibodies had #reactions with 28 [TWENTY-EIGHT!!] out of 55 tissue antigens
representing ...tissue groups that included:
â˘barrier proteins
â˘gastrointestinal
â˘thyroid
â˘neural tissues
and more.â
â...SARSCoV2 antibodies had #reactions with 28 [TWENTY-EIGHT!!] out of 55 tissue antigens
representing ...tissue groups that included:
â˘barrier proteins
â˘gastrointestinal
â˘thyroid
â˘neural tissues
and more.â
23.5/
â..selective epitope mapping using BLAST..
showed SIMILARITIES & #HOMOLOGY between SPIKE, nucleoprotein..
WITH
HUMAN tissue antigens:
⢠mitochondria M2
⢠F-actin
⢠TPO [thyroid peroxidase]
..extensive IMMUNE #CrossReactivity between..ANTIBODIES and different ANTIGENSâ >
â..selective epitope mapping using BLAST..
showed SIMILARITIES & #HOMOLOGY between SPIKE, nucleoprotein..
WITH
HUMAN tissue antigens:
⢠mitochondria M2
⢠F-actin
⢠TPO [thyroid peroxidase]
..extensive IMMUNE #CrossReactivity between..ANTIBODIES and different ANTIGENSâ >
23.6/ Quote
â[This IMMUNE #CrossReactivity] may:
⢠[affect] multi-system disease process of C19
⢠INFLUENCE #severity of disease
⢠PRECIPITATE onset of #autoimmunity in susceptible subgroups
⢠...exacerbate autoimmunity in subjects that have PRE-EXISTING #AutoimmuneDiseasesâ
â[This IMMUNE #CrossReactivity] may:
⢠[affect] multi-system disease process of C19
⢠INFLUENCE #severity of disease
⢠PRECIPITATE onset of #autoimmunity in susceptible subgroups
⢠...exacerbate autoimmunity in subjects that have PRE-EXISTING #AutoimmuneDiseasesâ
23.7/x Conât quoting
â..human monoclonal antibodies used are ... almost identical with [those recently approved for C19 patients].
Thus, our results can establish the potential risk for #autoimmunity and multi-system disorders with COVID-19 ...â >
â..human monoclonal antibodies used are ... almost identical with [those recently approved for C19 patients].
Thus, our results can establish the potential risk for #autoimmunity and multi-system disorders with COVID-19 ...â >
23.8/x Conât quoting
âthat may come from #CrossReactivity between:
⢠our own HUMAN TISSUES
and
⢠[SARSCOV2]
and thus ensure that ... [experimental mRNA/DNA] vaccines ... are truly safe to use against [Covid19].â
âthat may come from #CrossReactivity between:
⢠our own HUMAN TISSUES
and
⢠[SARSCOV2]
and thus ensure that ... [experimental mRNA/DNA] vaccines ... are truly safe to use against [Covid19].â
23.9/x Conât quoting
âIntroduction
... IMMUNOLOGISTS who focus on AUTOIMMUNITY have been concerned whether:
⢠infection
OR EVEN
⢠a newly developed [experimental mRNA/DNA] vaccine itself
can trigger #autoimmunity via #CrossReactivity.â
âIntroduction
... IMMUNOLOGISTS who focus on AUTOIMMUNITY have been concerned whether:
⢠infection
OR EVEN
⢠a newly developed [experimental mRNA/DNA] vaccine itself
can trigger #autoimmunity via #CrossReactivity.â
23.10/ Quoting
â #CrossReactivity occurs when..sequence #HOMOLOGY exists between:
⢠a PATHOGEN [eg vax-induced SARSCOV2 SPIKE]
&
⢠SELF-TISSUE [HUMAN] proteins.
...antibodies formed against SARSCoV2 would ALSO BIND TO HUMAN TISSUE proteins
leading to #autoimmune REACTIVITY.â
â #CrossReactivity occurs when..sequence #HOMOLOGY exists between:
⢠a PATHOGEN [eg vax-induced SARSCOV2 SPIKE]
&
⢠SELF-TISSUE [HUMAN] proteins.
...antibodies formed against SARSCoV2 would ALSO BIND TO HUMAN TISSUE proteins
leading to #autoimmune REACTIVITY.â
23.11/x Conât quoting
âAn insufficiently vetted [experimental mRNA/DNA] vaccine might mean
trading freedom from COVID-19
to an AUTOIMMUNE ASSAULT in the future.â
âAn insufficiently vetted [experimental mRNA/DNA] vaccine might mean
trading freedom from COVID-19
to an AUTOIMMUNE ASSAULT in the future.â
23.12/x Quote
â.. 3 Qâs regarding role of #CrossReactivity with SARSCoV2:
1) Does #CrossReactivity [
] multi-system disorders...?
2) How does #CrossReactivity contribute to..SARSCoV2âinduced #autoimmunity?
3) .. #autoimmune developmt with infection
ORâ
[VIA VAX-INDUCED SPIKE]?
â.. 3 Qâs regarding role of #CrossReactivity with SARSCoV2:
1) Does #CrossReactivity [
] multi-system disorders...?2) How does #CrossReactivity contribute to..SARSCoV2âinduced #autoimmunity?
3) .. #autoimmune developmt with infection
ORâ
[VIA VAX-INDUCED SPIKE]?
23.13/x Quoting
â...the issue of peptide SHARING between SARSCoV2 SPIKE glycoprotein and #LUNG_Surfactant proteins:
...because SARSCoV2 and #LUNG_Surfactant proteins SHARED 13 [THIRTEEN!!] of 24 pentapeptides,
the immune response following infection..[or vax-induced SPIKE]..â >
â...the issue of peptide SHARING between SARSCoV2 SPIKE glycoprotein and #LUNG_Surfactant proteins:
...because SARSCoV2 and #LUNG_Surfactant proteins SHARED 13 [THIRTEEN!!] of 24 pentapeptides,
the immune response following infection..[or vax-induced SPIKE]..â >
23.14/
âmay lead to #CrossReactions with pulmonary #surfactant proteins,
followed by [C19] lung disease
...indisputable proof of #molecularmimicry as potential mechanism for contributing to [C19] diseases
...warned AGAINST use of ENTIRE SARSCoV2 ANTIGENS in [mRNA/DNA]
vaccinesâ
âmay lead to #CrossReactions with pulmonary #surfactant proteins,
followed by [C19] lung disease
...indisputable proof of #molecularmimicry as potential mechanism for contributing to [C19] diseases
...warned AGAINST use of ENTIRE SARSCoV2 ANTIGENS in [mRNA/DNA]
vaccinesâ
23.15/x Quoting
âcautioned that..the use of ONLY UNIQUE PEPTIDES
would be most effective way to fight [C19].
Due to SIGNIFICANT RED FLAGS
for potential #CrossReactivity between SARSCoV2 and HUMAN TISSUE,..
[we studied] interaction of ANTIBODIES made against SARSCoV2 SPIKE..â
âcautioned that..the use of ONLY UNIQUE PEPTIDES
would be most effective way to fight [C19].
Due to SIGNIFICANT RED FLAGS
for potential #CrossReactivity between SARSCoV2 and HUMAN TISSUE,..[we studied] interaction of ANTIBODIES made against SARSCoV2 SPIKE..â
23.16/x Quoting
â... with various #autoimmune target proteins associated with many serious diseases.
..we can establish the potential risk for #autoimmunity and multi-system disorders with C19
that may come from #CrossReactivity between OUR OWN HUMAN TISSUES and [SARSCOV2]...â
â... with various #autoimmune target proteins associated with many serious diseases.
..we can establish the potential risk for #autoimmunity and multi-system disorders with C19
that may come from #CrossReactivity between OUR OWN HUMAN TISSUES and [SARSCOV2]...â
23.17/x
âResults
..SARSCoV2 antibodies reacted from low to very high with 28 of 55 [HUMAN] tissue antigens...[including]:
⢠gut & barrier proteins
⢠gastrointestinal system cells
⢠thyroid
⢠nervous system
⢠heart
⢠joint
⢠skin
⢠muscle
⢠mitochondria
⢠liver
tissuesâ
âResults
..SARSCoV2 antibodies reacted from low to very high with 28 of 55 [HUMAN] tissue antigens...[including]:
⢠gut & barrier proteins
⢠gastrointestinal system cells
⢠thyroid
⢠nervous system
⢠heart
⢠joint
⢠skin
⢠muscle
⢠mitochondria
⢠liver
tissuesâ
23.18/x Quoting
âand antigens used for the screening of #autoimmune diseases.
...
HUMAN anti-SARSCov2 SPIKE protein antibody reacted:
⢠STRONGEST with neurofilament protein or NFP
⢠followed by STRONG reactions with M2, GAD-65, and nuclear antigen or NAâ
âand antigens used for the screening of #autoimmune diseases.
...
HUMAN anti-SARSCov2 SPIKE protein antibody reacted:
⢠STRONGEST with neurofilament protein or NFP
⢠followed by STRONG reactions with M2, GAD-65, and nuclear antigen or NAâ
23.18/x
âThe reaction of SPIKE protein antibody with TPO [thyroid peroxidase]
and liver microsome was moderate.
..
Table 1 - SPIKE protein antibody exhibited SIGNIFICANT reactions with 25 of 55 tested target proteins,
with the STRONGEST reactions coming from NFP and M2 antigensâ
âThe reaction of SPIKE protein antibody with TPO [thyroid peroxidase]
and liver microsome was moderate.
..
Table 1 - SPIKE protein antibody exhibited SIGNIFICANT reactions with 25 of 55 tested target proteins,
with the STRONGEST reactions coming from NFP and M2 antigensâ
23.19/x Quoting
âDiscussion
>7,000 peer-reviewed studies published on #molecularmimicry and #autoimmune diseases
and >50 recognized #crossreactive relationships between specific viral pathogens and HUMAN tissue proteins [prior to 2020] (1, 4, 8, 14â20).â
âDiscussion
>7,000 peer-reviewed studies published on #molecularmimicry and #autoimmune diseases
and >50 recognized #crossreactive relationships between specific viral pathogens and HUMAN tissue proteins [prior to 2020] (1, 4, 8, 14â20).â
23.20/
â #molecularmimicry between SARSCoV2 and HUMAN proteins
..connection between #mimicry and multi-organ disorders
immune response against viral ANTIGENS following infection OR VACCINATION can #crossreact with HUMAN TISSUE antigens that SHARE sequence HOMOLOGY with[eg SPIKE]â
â #molecularmimicry between SARSCoV2 and HUMAN proteins
..connection between #mimicry and multi-organ disorders
immune response against viral ANTIGENS following infection OR VACCINATION can #crossreact with HUMAN TISSUE antigens that SHARE sequence HOMOLOGY with[eg SPIKE]â
23.21/x Quoting
âresulting in #autoimmune_reactivity,
possibly followed by OUTRIGHT AUTOIMMUNE DISEASE (5, 10, 19, 24, 25).
Some support for this proposed mechanism for induction of #autoimmunity was presented
...compared #immunogenic EPITOPES of SARSCoV2
to
HUMAN proteinsâ
âresulting in #autoimmune_reactivity,
possibly followed by OUTRIGHT AUTOIMMUNE DISEASE (5, 10, 19, 24, 25).
Some support for this proposed mechanism for induction of #autoimmunity was presented
...compared #immunogenic EPITOPES of SARSCoV2
to
HUMAN proteinsâ
23.22/
âfound a HIGH degree of HOMOLOGY with..[including]:
⢠heart muscle
⢠skeletal muscle
⢠thyroid gland
⢠kidney
⢠brain
⢠pituitary gland
⢠testes
⢠lung
⢠BLOOD
⢠GI tract
⢠eye
⢠liver
⢠bone marrow
⢠adipose tissue
⢠skin
and many ubiquitous proteins (5).â
âfound a HIGH degree of HOMOLOGY with..[including]:
⢠heart muscle
⢠skeletal muscle
⢠thyroid gland
⢠kidney
⢠brain
⢠pituitary gland
⢠testes
⢠lung
⢠BLOOD
⢠GI tract
⢠eye
⢠liver
⢠bone marrow
⢠adipose tissue
⢠skin
and many ubiquitous proteins (5).â
23.23/x
â...key target human tissue proteins known to be involved BOTH with:
⢠extra-pulmonary manifestations of C19
and
⢠common #autoimmune diseases.
..we studied:
⢠alpha-myosin [in heart muscle]
⢠actin [in skeletal muscle]
⢠TPO [thyroid peroxidase, in thyroid gland]â
â...key target human tissue proteins known to be involved BOTH with:
⢠extra-pulmonary manifestations of C19
and
⢠common #autoimmune diseases.
..we studied:
⢠alpha-myosin [in heart muscle]
⢠actin [in skeletal muscle]
⢠TPO [thyroid peroxidase, in thyroid gland]â
23.24/x Quoting
âLyons-Weiler studied:
⢠brain
⢠liver
⢠GI tract
⢠skin
whereas we examined SARSCoV2 #crossreactivity with:
⢠brain tissue ANTIGENS (MBP, NFP, amyloid-beta, alpha-synuclein, synapsin, tTG-6)
⢠liver microsomal peptide
⢠M2 protein
⢠PDH peptide... â >
âLyons-Weiler studied:
⢠brain
⢠liver
⢠GI tract
⢠skin
whereas we examined SARSCoV2 #crossreactivity with:
⢠brain tissue ANTIGENS (MBP, NFP, amyloid-beta, alpha-synuclein, synapsin, tTG-6)
⢠liver microsomal peptide
⢠M2 protein
⢠PDH peptide... â >
23.25/x Quoting
â ⢠skin antigens (tTG-2, tTG-3, epithelial cell antigens)
...many other tissue antigens [examined], such as barrier proteins..
...[does] human monoclonal antibody that mimics natural antibodies...react to various HUMAN TISSUE antigens[?]â
â ⢠skin antigens (tTG-2, tTG-3, epithelial cell antigens)
...many other tissue antigens [examined], such as barrier proteins..
...[does] human monoclonal antibody that mimics natural antibodies...react to various HUMAN TISSUE antigens[?]â
23.26/x Quoting
âThis immune reaction may be responsible for the multi-organ system disorder [in] severe C19.
...
Our present study used human #monoclonal_antibodies against SARSCoV2 proteins [including SPIKE], and we found reactivity with 28 out of 55 tested human antigens ..â
âThis immune reaction may be responsible for the multi-organ system disorder [in] severe C19.
...
Our present study used human #monoclonal_antibodies against SARSCoV2 proteins [including SPIKE], and we found reactivity with 28 out of 55 tested human antigens ..â
23.27/x Quoting
âThis #crossreactivity with so many [HUMAN] ANTIGENS raises important CLINICAL CONCERNS.
3) understanding the relationship of SARSCoV2 [including vax-induced SPIKE]
with
#autoimmunity
can help predict potential ADVERSE REACTIONS from ..experimental vaccine..useâ
âThis #crossreactivity with so many [HUMAN] ANTIGENS raises important CLINICAL CONCERNS.
3) understanding the relationship of SARSCoV2 [including vax-induced SPIKE]
with
#autoimmunity
can help predict potential ADVERSE REACTIONS from ..experimental vaccine..useâ
