#Immunogenic

This is a great question. Here’s my responsehttps://twitter.com/dianaberrent/status/1330255535808122881?s=20 The idea of vaccines is to get you to immunity without having to go through the risk and discomfort of illness, and

Vincent Rajkumar

Should we vaccinate now? @StevenSalzberg1 @Forbes 1) To be clear: No one is recommending skipping phase 3 trials. Those must be completed. Question is should a parallel pathway be available

James Todaro, MD

1/ An unknown side effect of lengthy lockdowns may be decreased crossover immunity to COVID-19.Research on SARS-CoV-1 suggests that lack of exposure to the common cold coronaviruses could actually worsen

Severe #COVID19 induces an endotheliitis: a pseudo-vasculitis phenotype with a viral renal-lung syndrome and ARDS. Nephrologists report AKI without shock/renal hypoperfusion. Microvascular endotheliitis also explains cardiac manifestations & thro

An mRNA Vaccine against SARS-CoV-2 — Preliminary Report | NEJM [Moderna Vaccine Phase 1 Trial summary]https://www.nejm.org/doi/full/10.1056/NEJMoa2022483 The mRNA-1273 vaccine was immunogenic, inducing robust binding antibody responses to

Daniel De Carvalho

Our manuscript ‘Epigenetic therapy induces transcription of inverted SINEs and ADAR1 dependency’ is out today @nature. Congratulations to first authors @Pari_Mehdipour @sajidMarhon and @IliasEttayebi for this amazing work!https://www.na

Gabor Erdosi 🧩📄📊🧭

There’s a curious correlation between countries/regions of high prior SARS2 exposure and a resurgence upon the start of mass V immunization programs. I’ve been thinking a lot about this lately,

Prof. Akiko Iwasaki

VirusesImmunity

Several studies are coming out saying that blood LDH (lactate dehydrogenase) levels early in #COVID19 disease correlates with severe disease progression. This is a clue that #pyroptosis may be a

Vincent Rajkumar

Astra Zeneca vaccine & blood clots. Summary.Rare form of blood clots plus low platelets. ~60% involve veins of brain. Almost all after 1st dose. Risk (UK MHRA): 1 in 250,000

Global Forum TB Vax

Ann Ginsberg reminds us that ‘improved TB vaccines are feasible' as she gave a quick overview of the pipeline & candidates to be discussed today:M72/AS01E (@gatesfoundation)DAR-901 (@GeiselMed)MTBVAC (@zendalgroup)H56:IC31 (@ssi_d

James Todaro, MD

1/ Growing research demonstrating importance of protective T-cells against SARS-CoV-2 combined w/ prior research on influenza viruses suggest that nasal mucosa T-cells may explain the rising number of "positive" PCR

Dr. Angela Rasmussen

angie_rasmussen

Big news today about another vaccine candidate. Take home messages:-It's safe-It's immunogenic (neutralizing antibodies and antigen-specific T cells)-It's a good size (n=1077 patients, 543 of whom got the vaccine vs

Sabina Walker 😀 Master Appl Science (Neuroscience

1/x Platelets Can Associate With SARSCoV2 RNA and Are Hyperactivated in C19 (17/9/2020)Quoting,“...HYPERCOAGULATION and THROMBOSIS contribute to lethality of [C19].Platelets are chiefly implicated in thrombosis.[platelets] CAN interact wi

1. The @Ligandal antidote to #SARSCoV2 has been getting a lot of attention, but some people are having difficulty understanding how it works and what makes it so promising, so

Dr. Sanjay Gupta

Every day it seems like there’s a slew of new research about #COVID19 …and news stories to go along with them. Between January and May, an estimated 23,000 papers came

Sarah Constantin

My current “impractical” project is building a comprehensive list of interventions that cause >20% complete tumor regression in metastatic solid tumors. Basically, the hardest of hard modes for cancer. I