#Epitopes

Chise 🧬🧫🦠💉

Let’s talk about B.1.617. It is unlikely it will be able to evade vaccine-induced immunity. Why?•Vaccines are polyclonal (Abs)•Mutations compared to VOCs•CD8+ T-cells covering 52 epitopes across the spike protein•CD4+

might fuck around and do a long detailed t-cell thread there's a lovely new paper that sheds a lot of light on CD8+ (aka killer/cytotoxic) T cells in COVID-19 and

Claudina MICHAL-TEITELBAUM

MartinFierro769

1/n Une étude très importante via @docdu16 et @akira_doe qui vient confirmer l'importance, du thymus, des lymphocytes T et des épitopes CONSERVES dans la résistance à l'infection par le SARS-CoV-2

Eric Meyerowitz, MD

1/ I'm going to try to contain myself, but very important/elegant article out tonight in Cell with potentially critical implications for immunity as well as a possible explanation for differential

SARS-CoV-19 Preprints

1/11 Analysis of humoral immune response in #COVID19 patients provides key insights for #ConvalescentPlasma therapy and #Vaccine research: https://www.medrxiv.org/content/10.1101/2020.03.30.20047365v1 2/11 A pseudotyped-lentiviral-vector-based neutra

1/n Okay, here's a long breakdown of the lab's recent preprint. I have to say I am so excited by this project! SO MUCH WORK by such a great group

CD8+ T cells play an important role in clearing respiratory virus. I looked at 10 preprints from @biorxivpreprint and @medrxivpreprint all exploring T cell responses to #SARS2/#COVID19. In no particular

We've written a perspective on a new study by @MAMdayIndayOut that helps explain why some viruses (measles) don't evolve to escape immunity but others (influenza) do. Provides some clues relevant

Monica Gandhi MD, MPH

Why should we not worry about VARIANTS "escaping" immunity from vaccines or natural infection; why are we not likely to need vaccine BOOSTERS? Remember immunity is both antibody and cell-mediated

profshanecrotty

1/ There are several major aspects of what Scott Atlas is saying that are wrong.https://twitter.com/hholdenthorp/status/1309115311073918977 2) There is no direct evidence that pre-existing T cell immunity affects COVID-19 infections. LJI

Monica Gandhi MD, MPH

Wanted to drill down a bit more about the importance of the T-cell response to SARS-CoV-2 to give you more reassurance of enduring protection from vaccines (even against variants). Technical

Dr. Angela Rasmussen

angie_rasmussen

So the President received 8 grams of Regeneron monoclonal antibodies as a therapy & while that seems like a huge dose, we've been here before...Ebola patients evacuated from W. Africa

David Maizenberg

biologypartners

"The need to assess the potential of vaccine candidates to inadvertently worsen future coronavirus infections through a process called antibody-dependent enhancement was a major topic of discussion" https://www.biocentury.com/arti

Andre Watson 🧬💊💉

Here is the virus in "closed" (teal) and "open" (green) form. In "open" form, it binds to ACE2. ACE2 also blocks the ideal neutralizing antibody sites, and binds with extremely

Priya Sampathkumar

PSampathkumarMD

Cross reactive immunity to COVID?Several studies now suggest that T cells reactive to COVID may be present even in persons without prior exposure to SARS CoV-2 suggesting presence of cross

One of the biggest mysteries of Covid-19 has been why some people become very ill, while a large number of people who are infected show no symptoms at all. It