#RCTs

RCTs having limitations and/or weak or misleading design does not automatically make observational studies better.Observational studies having limitations and/or weak or misleading design does not automatically make RCTs better.Limitations

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DrAbdulRazak_MD

Cochrane review is out - Authors are not convinced that #probiotics are helpful in preterm infantsIt says “large RCTs are needed..,” despite 56 #RCTsWould you agree w/ them knowing that

1/#UncleBob enters troubled waters for #5goodminutes Yesterday, my twitter feed exploded with the “religion” of RCTs. If not an RCT, then we have not useful data. But RCTs have their

🔥 Kareem Carr 🔥

The current moment is a master class in the practical limitations of RCTs. We’re seeing that:1. RCTs are slow, expensive and don’t scale well to large numbers of questions.2. Extending

Robert M Califf

Important statement from RECOVERY Trial in UK about continuing RCT of hydroxychloroquine. @texhern @HeartBobH @gcfmd @PCORnetwork @ASlavitt https://www.recoverytrial.net/files/professional-downloads/recovery_noticetoinvestigators_2020-05-24

This article from @ThePrintIndia says The Lancet observational study was on treatment, but the ICMR is recommending HCQ as prophylaxis, and so they are not comparablehttps://theprint.in/health/icmr-lancet-hcq-study-arent-at-odds-one-is-on-p

1/ Here are the relative effects (Y axis) and the p-values (X axis) found for all the 6 clinical outcomes measured by the 3 outpatient RCTs of HCQ for covid

This paper is a mess in my view. https://www.thelancet.com/action/showPdf?pii=S0140-6736%2820%2931180-6 The propensity model has very low likelihood of capturing the indication bias, and the fidelity of the data (huge registry with

CODESRIA has just published its Bulletin on RCTs.This is the beginning of pan-African and South-South conversations on the role of RCTs in the South. Whether we critique or defend, this

As we think about convalescent plasma (CP), I thought it was worth looking at the actual data in other diseases. As best I can tell, the only actual trial showing

Margaret McCartney

at times like these, we really do need to stick to EVIDENCE. it will always be incomplete. any course of action risks unintended consequences. we have to be honest about

Luciana Borio, MD

Thread: 1. Recent statements by @SteveFDA that @US_FDA may authorize #COVID19 vaccines before completing clinical trials are generating much anxiety and setting up a twitter storm. @Pfizer frequent messaging that

Jonathan Shedler

JonathanShedler

1/ I get asked this all the time so thought I'd put it in a tweet for whoever needs it. In 2010, I published "The efficacy of psychodynamic psychotherapy," which

Graham Boniface

graham_boniface

A thread about our new paper… A systematic review exploring the evidence reported to underpin exercise dose in clinical trials of rheumatoid arthritis https://academic.oup.com/rheumatology/advance-article/doi/10.1093/rheumatology/keaa150/

We had been told by various sources WHO committee reviewing the evidence had not backed masks but they recommended them due to political lobbying. This point was put to WHO

"How Much Can We Generalize From Impact Evaluations" is out at JEEA!Here's a thread with the key takeaways.... 1/https://twitter.com/JEEA_News/status/1318780863912529920 Impact evaluations have taken off in development economi