Cochrane review is out - Authors are not convinced that #probiotics are helpful in preterm infants

It says “large RCTs are needed..,” despite 56 #RCTs

Would you agree w/ them knowing that the effect size is substantial & confidence limits are tight w/ large population

@EBNEO

How would large RCTs improve evidence’s certainty when prior study limitations will continue to affect evidence

Unless they rely on evidence from sensitivity analysis of high-quality RCTs in future MA

If so, the current Ss analysis is not informative? https://is.gd/CI2tgy ">https://is.gd/CI2tgy&qu...

So, would you not use probiotics till then?

It would be long time, probably many years, for us to see large RCTs enrolling ELBW babies and informing us to practice or not

@ravimpatelmd @crmartin90 @NECsociety @SamOddie @NeonatalResearc @NeoResearch_Net
@NICU_Musings @EBNEO