Samuel Brown, Discover and Read the Best of Twitter Threads by @DrSamuelBrown

Samuel Brown

DrSamuelBrown

The letter from the treating physician for the US president is emblematic of “VIP medicine”. Almost none of it is a good idea even on its own, and no one

This CDC thing about a small minority of the COVID deaths being among previously healthy individuals? A few thoughts. First, we already knew that SARS-CoV-2 is ruthlessly Darwinian in its

As we think about convalescent plasma (CP), I thought it was worth looking at the actual data in other diseases. As best I can tell, the only actual trial showing

We don't talk about lawsuits much in medicine. Too painful. I got sued when I was a resident. An intern had written a note that was misinterpreted to mean that

Some thoughts about the RECOVERY-DEX preprint. First, some more clarity about why it stopped--it hit the target sample size. Oddly, no discussion about alpha spend or what the DSMB reviewed.

This paper is a mess in my view. https://www.thelancet.com/action/showPdf?pii=S0140-6736%2820%2931180-6 The propensity model has very low likelihood of capturing the indication bias, and the fidelity of the data (huge registry with

For clarity, what do we know about treatment of COVID19 (recognizing that knowledge is a spectrum here)? Here's a list (with appropriate caveats) of what we can credibly claim to

@hskulkarni raised an important point about communication that raised for me a key cultural chasm that we should address head on. We in intensive care have watched over the last

One last quick comment on reporting mortality generally, as this recent NY paper is one of many. We've been reporting mortality for many decades, and we have some conventions. First,

I love @Michael_Harhay 's fascinating paper about adult critical care trials. https://www.atsjournals.org/doi/suppl/10.1164/rccm.201401-0056CP I did some manual calculations trying to ask how often trials that aimed at mortality were nominally po