#Serology

The US needs SEROLOGY tests. Shocking how little this is talked about. Serology tests looks for antibodies to see if you’re immune to COVID-19 / already had it. A serology

Catherine Moore 🦠🧬🇪🇺🏴󠁧󠁢󠁷󠁬󠁳󠁿🇬🇧

We do NOT routinely use serology to diagnose or even confirm past infection with ANY respiratory virus. Even influenza. Few labs may still use complement fixation tests, but they require

#COVID19 Serology (aka. #antibody) testing is a popular topic. Here is a tweetatorial on where things stand today in Ontario. As @UHN’s Deputy Division Head for Biochemistry, test validation and

Scott Gottlieb, MD

ScottGottliebMD

Doctors should be aware most serology tests haven't been reviewed by FDA. Quality is highly variable, with some or perhaps many giving uncertain results. False positive rates may be inappropriately

1/ I'm sorry - I don't like arguing with physicians - but the notion that we should be WORRIED about the antibody test findings showing that many people have had

Caitlin Rivers, PhD

Lots of serosurveys trickling out, some with more heat than light. Let’s not miss the forest for the trees. A thread. 1/ Whether seroprevalence is 2% or 3% is mostly

1/ There's a lot of debate about the accuracy of #COVID tests right now. But the real question is, how accurate do you need? There seem to be main two

Moebius Stripper

An excellent question about the accuracy of serology tests. THREAD, WITH SPREADSHEET THAT YOU CAN DOWNLOAD AND PLAY WITH!https://twitter.com/delta_vee/status/1260928159521878016 I'm going to riff off this thread about a particular COVID-19

Ok. Here's a little insight into the life of an infectious disease epidemiologist trying to handle uncertainty and report responsibly. Warning - the coming thread will contain many "i'm not

Recent serology studies may be wrong. But if wrong, they‘re all wrong *in the same direction.*Finnish: 20-50x undercountScottish: 27-55xStanford: 50-85xItalian: 30xMass: 17xGermany: 0.37% CFRDenmark: 0.21%If true, COVID19 has much more

Rich Davis, PhD, D(ABMM), MLS 🦠🔬🧫

Good thread on sensitivity & specificity of first emergency use authorization (EUA) #COVID19 serology test, Cellex, means for testing a low-prevalence population: increased risk of false positivesBUT IT'S ACTUALLY WORSE

Dr. Angela Rasmussen

angie_rasmussen

This is misleading. Serum antibody titers normally fall after you recover from an infection...the high titers induced by the infection decrease to baseline. The implications for immunity are unclear.Here's a

Having antibodies doesn't necessarily mean you're immune to the virus. We don't know enough yet to say what kind of immunity antibodies provide or long that immunity lasts. These tests

Rajeev Venkayya MD

This is a thread on the use of antibody tests (serology) to gauge individual risk for COVID-19 infection. It's triggered by the recent @WHO guidance and the push for "immunity

A preprint published Monday shows that among 175 recovered COVID-19 patients from Shanghai, 30% showed a low neutralizing antibody response, with 10 patients showing undetectable antibodies. https://www.medrxiv.org/content/10.1101/2020.03.30.20047365

Lots of serology happening around the world, so I thought I'd do a thread collating some of the infection-fatality estimates for #COVID19 1/n 2/n INFECTION-fatality rate (IFR) is the rate