#Pathogenesis

Justin Yerbury AM

#MND #ALS is a heterogeneous disease & some say it should be distinct syndromes. Today our theory on how proteome homeostasis (proteostasis) is a unifying principle of ALS is published

Excited to share my new paper with @ActinDomain! We are proposing an updated definition of #EDS/#HSD, and explain how they could all be disorders of membrane-bound collagen. We explain the

Shane McAuliffe RD

In the spirit of #DietitiansWeek & #MythbustingMonday, I thought I would chip in with one that has been a staple throughout my clinical training: Albumin is not a good marker

Curious about what’s going on in submission/peer review/publication of SARS-CoV-2 studies? Me too! TL;DR, it’s NUTS. (1/7) In the past month or so, as an editor and reviewing editor at

Dear @livingwithmcas, do you know of other studies than the ones below with intravenous vitamin C and MCAS? A friend is going into the hospital soon, and we want to

mojicanicotinic

How to become a Veterinarian?a thread: i will not mention all the pre- veterinary courses this thread mostly consists of proper subjects a list of courses with sub courses within

Dr. Angela Rasmussen

angie_rasmussen

New paper shows that smoking cigs increases expression of the #SARSCoV2 receptor ACE2. The idea here is more ACE2, more infection, worse #COVID19.This is a faulty assumption.https://www.atsjournals.org/doi/abs/10.1164/rccm.202003-0693LE#.XqW1P4Cg3FM.

Thiago Carvalho

So here's an interesting preprint from @carolilucas, @VirusesImmunity et al serially analysing "immune responses in 113 COVID-19 patients with moderate (non-ICU) and severe (ICU) disease."https://www.medrxiv.org/content/10.110

1/Why is tricuspid valve (TV) endocarditis more common in those who use intravenous drugs?The portal of entry for most bacteria is the venous system. If quick access to the right-heart

profshanecrotty

1/ Recently, major media outlets in the US and France have mischaracterized our COVID-19 T cell findings. We have now published a summary of current knowledge to correct this.https://www.nature.com/articles/s41577-020-0389-z 2/

As with so many acute severe infectious diseases it is a delicate balancing act - the immune response is both essential & part of the problem.https://www.theguardian.com/science/2020/oct/04/scientists-study-whether-immune-response-wards

1/5 African S. Typhimurium ST313 has 23 Lineage 2-specific pseudogenes, discovered by @DrRobKingsley in 2009, inc ybjZ.But what is function?In collab with Jared Honeycutt @monack_lab, we've discovered that MacB (YbjZ)

The Chronic Theory ♿️

Some 2020 research on MCAS, hEDS, POTS. It’s going to prove controversial. ‘We conducted an extensive review of the literature using two different search strategies. All three clinical entities are

Kristian G. Andersen

A few comms on the (lack of) scientific merits of the "Yan Report". It is non-scientific and false - cherry picking data and ignoring data disproving their hypotheses.It's using technical

1/n I am asked on a daily basis about IL-6 blockade in #COVID19 patients @sloan_kettering . The truth is that I don't know if this intervention is helpful, neutral, or

Dr. Angela Rasmussen

angie_rasmussen

This type of reporting on #SARSCoV2 #COVID19 #coronavirus makes my blood boil. There is no evidence that the dominant strain is such because it is "more contagious"https://www.latimes.com/california/story/2020-05-05/mutant-coronavirus-has-e