#MND #ALS is a heterogeneous disease & some say it should be distinct syndromes. Today our theory on how proteome homeostasis (proteostasis) is a unifying principle of ALS is published @TrendsNeuro https://www.cell.com/trends/neurosciences/fulltext/S0166-2236(20)30048-5">https://www.cell.com/trends/ne... This is >10 years in the making. Let me explain: 1/7

12 years ago, at the MND/ALS symposium I spoke with a prominent neurologist/researcher and I ran my idea by him. He told me that it was too complicated and that I should work on it a bit, collect some evidence. Today we publish the result. In essence it goes like this:
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What is a proteome exactly? A proteome is all the proteins in a cell made from the instructions in your DNA. These molecular machines do vital work and include things like haemoglobin to transport oxygen, enzymes to digest food, and collagen to provide physical structure... 3/6

There are around 20,000 different possible proteins and there are almost as many individual protein molecules in an average human body as there are stars in the universe.. 4/6

The job of keeping all these protein molecules in balance is a gigantic task, and sometimes it can be too much for a cell to deal with. We are just beginning to understand the complexities of maintaining the balance of proteins in a motor neuron that can be 1m in length… 5/6

We hope that our paper provides a framework that will help us make sense of some of the the complexity around the pathogenesis of #ALS #MND. @NatalieFarrawe1 @LukeMcAlary @uowresearch @ihmri https://www.cell.com/trends/neurosciences/fulltext/S0166-2236(20)30048-5">https://www.cell.com/trends/ne...