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Some 2020 research on MCAS, hEDS, POTS. It’s going to prove controversial.
‘We conducted an extensive review of the literature using two different search strategies. All three clinical entities are controversial in either existence or pathogenesis.’ #hypermobility #MCAS #hEDS https://pubmed.ncbi.nlm.nih.gov/31267471/
‘MCAS is a poorly defined clinical entity, and many studies do not adhere to the proposed criteria when establishing the diagnosis. Patients previously diagnosed with EDS hypermobility type may not meet the new, stricter criteria for hEDS but may for a less severe (HSD)’
‘Studies proposing a relationship between the three clinical entities are either biased or based on outdated criteria..’
‘The reason behind the purported association of these entities stems from an overlapping pool of vague, subjective symptoms, which is inadequate evidence to conclude that any such relationship exists.’ Alison Kohn et al. Clin Rev Allergy Immunol. 2020 Jun. https://pubmed.ncbi.nlm.nih.gov/31267471/
I had to get the full article because this is wild... wait for it...
‘In the twenty-first century, medical information is not always disseminated in scientific or medical journals, but among internet sites of less-well repute.’
‘Furthermore, despite the increasing number of patients who present with a diagnosis, valid or not, of all three conditions, it is difficult to come up with a plausible mechanistic reason as to why they would be related.’
