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For reference, here is the recent report alleging a potentially artificial origin for SARS-CoV-2, from virologist Li-Meng Yan.https://zenodo.org/record/4028830#.X1_G1mhKg2zhttps://en.wikipedia.org/wiki/Li-Meng_YanYan recently fled Hong Kong
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Summary note on staging for COVID-19.This list is not definitive. Just heuristics.Many authors draw the mild/moderate division around where the patient will soon need oxygen support, SpO2 nearing 90-92% on
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Post-acute "long COVID-19" mostly presents with fatigue, myalgia, shortness of breath, and headaches.The most affected organs are the heart and lungs. Impairment is often worse in formerly hospitalized cases. Neurological
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Pardon delayed responses. I seem to have contracted a respiratory virus after maintenance staff visited my residence.On the bright side, treatments discussed seem to work. Mostly feeling better after ~2.5
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GS-441524 is substantially less toxic than remdesivir, far easier to synthesize, more soluble, and has essentially identical effects because remdesivir is apparently metabolized into it (in spite of having been
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Recent research indicates that different strains of the novel coronavirus SARS-CoV-2 do indeed have meaningful differences in pathogenicity.This was difficult to confirm previously.SCMP summary article:https://www.scmp.com/news/china/science/article/
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COVID-19 antiviral EC50s expected hittable:- amodiaquine- atazanavir- camostat- chloroquine- ciclesonide- dipyridamole- doxycycline- favipiravir- hydroxychloroquine- HTCC polymer- IFN-α 2b- indomethacin- itraconazole- mefloquine- nelfinavir- niclosam
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Eastern Virginia Medical School COVID-19 protocol:https://www.evms.edu/media/evms_public/departments/internal_medicine/EVMS_Critical_Care_COVID-19_Protocol.pdfThe EVMS guidelines take an expansive, proactive approach to case management.They try to be
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Nice visual overview, for those who haven't seen it yet. When researchers discuss interfering with the function of the SARS-CoV-2 Spike protein, they are referring to the knobby proteins protruding
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https://naspa.us/resource/hydroxychloroquine-chloroquine-and-azithromycin/U.S. state rules on prescriptions for [hydroxy]chloroquine vary quite widely, according to local political posturing, affinity for red tape, etc.Be sure to remember your prefer
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I think the most overlooked factors right now are probably:1) risk of pulmonary microthrombi (practice appears to be converging on prophylactic enoxaparin, see e.g. Yale guidance)2) secretions, risk of hyaline
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Critical COVID-19 cases in ARDS show perverse hypoxemia in spite of decent lung compliance.This is odd. Some people have even made far-fetched claims about supposed damage to RBCs or heme,
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