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Eric Topol
EricTopol
Initially #SARSCoV2 was considered a respiratory virus. New @GladstoneInst findings in both iPSC-> heart cells & autopsy indicate it's a heart virus, w/ a distinct pattern:—myofibrillar fragmentation—loss of nuclear DNA—&qu
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Today's "breakthrough" announcement is unlikely to be any breakthrough.1. Convalescent plasma has no randomized trials. It contains many antibodies that have no neutralizing effect. If it has efficacy, it will
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Just published @CellCellPress "SARS-CoV-2 elicits robust, broad and highly functional memory T cell responses, suggesting that natural exposure or infection may prevent recurrent episodes of severe COVID-19" https://www.cell.com/c
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Nature can be beautiful but also evil.It has brought us the worst pandemic in more than 100 years.What is it about #SARSCoV2 that makes it so nefarious? 1/ As compared
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1. The early use of inhaled interferons is emerging as a promising strategy to prevent severe #COVID19: lines of support include mechanism, rare genomic variants, a multicenter retrospective report, and
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"These data support calls for the recognition of aerosol (ie, traditional airborne) transmission of #SARSCoV2"An exceptional review of particle sizes of various pathogens and what can be done to limit
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Now with ~1,000 children and adolescents with multi-inflammatory syndrome in children (MIS-C), it can be considered a new disease. Today new @NEJM reports and an editorial on its status. I've
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Just published @TheLancet is the Oxford Phase 1 #SARSCoV2 vaccine trial with very encouraging safety data, neutralizing antibody and spike protein specific T cell responsehttps://www.thelancet.com/lancet/article/s0140-6736(20)31604-4 And an
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The Phase 1 of the @moderna_tx #SARSCoV2 vaccine results published @NEJM today and they are very encouraging for immune response and safety in 45 healthy people, 2 shots, increasing doses
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What we've been missing, below the surface, about #COVID19. The focus has been on confirmed cases, hospitalizations and deaths. But there's so much more we've been learning. United States data
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When we don't measure important stuff.A thread about the immune response to #SARSCoV21. Since serology/IgG can be readily measured, this is what is conventionally used to assess an individual's responseThat's
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One of the most important #COVID19 controversies: Should we reopen schools? Just out is a piece that reviews everything we know: the many outbreaks, the age gradient, distancing, masks, testing,
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