1. The early use of inhaled interferons is emerging as a promising strategy to prevent severe #COVID19: lines of support include mechanism, rare genomic variants, a multicenter retrospective report, and a small randomized trial

2. On mechanism, our innate immune response, first line of defense relies, at least in part, on the interferon response.
2 figures from @VirusesImmunity& #39;s terrific thread, and the link to it
https://twitter.com/VirusesImmunity/status/1285944893085491204">https://twitter.com/VirusesIm...

3. Yesterday& #39;s @JAMA_Current report of loss-of-function TRL7 rare variants in 4 young men from 2 independent families w/ severe #COVID19 connects with their impaired interferon response
Editorial @rplenge https://jamanetwork.com/journals/jama/fullarticle/2768925
Paper">https://jamanetwork.com/journals/... by @ahoischen et al https://jamanetwork.com/journals/jama/fullarticle/2768926">https://jamanetwork.com/journals/...

4. Multicenter report of inhaled interferon-alpha2b (Type1) showed benefit if given early, harm if late (opposite of pattern with dexamethasone)
https://www.cell.com/cell-host-microbe/fulltext/S1931-3128(20)30401-7">https://www.cell.com/cell-host... @cellhostmicrobe

5. A small randomized trial of inhaled beta interferon in 100 patients, only available via press release so far, but very encouraging
results https://www.synairgen.com/wp-content/uploads/2020/07/200720-Synairgen-announces-positive-results-from-trial-of-SNG001-in-hospitalised-COVID-19-patients.pdf
and">https://www.synairgen.com/wp-conten... important caveats here, by @benjmueller
https://www.nytimes.com/2020/07/20/world/covid-19-treatment-synairgen-interferon-beta.html">https://www.nytimes.com/2020/07/2...

6. There are dozens of ongoing trials, an overview by @meredithwadman @ScienceMagazine https://science.sciencemag.org/content/369/6500/125
but">https://science.sciencemag.org/content/3... if this holds up it will be the first class of drugs that can be given early in the course of an infection, fulfilling a major unmet need

2 points to add:
—a @pbleic thread on the biology of TLR7, interferons and another ? contributor for thehttps://abs.twimg.com/emoji/v2/... draggable="false" alt="⬆️" title="Pfeil nach oben" aria-label="Emoji: Pfeil nach oben"> vulnerability in men
https://twitter.com/pbleic/status/1287002569324150785
—thinking">https://twitter.com/pbleic/st... about rapid #SARSCoV2 testing and early inhaled interferon to change the natural history of infections is exciting