Just published @CellCellPress
"SARS-CoV-2 elicits robust, broad and highly functional memory T cell responses, suggesting that natural exposure or infection may prevent recurrent episodes of severe COVID-19" https://www.cell.com/cell/fulltext/S0092-8674(20)31008-4?rss=yes">https://www.cell.com/cell/full... by @karolinskainst

Unique, full spectrum study of acute and convalescent patients, family members exposed but seronegative, healthy unexposed
SARSCoV2 specific T cells present even in asymptomatic individuals, mild cases, and antibody-negative family members exposed
Important findings!

The dissociation of antibody (its absence) and a robust T cell response is noteworthy.
It reinforces how much we miss by focusing on antibodies out of convenience, since T cells response is only assessed in research labs
Connects w yesterday& #39;s case report https://abs.twimg.com/emoji/v2/... draggable="false" alt="👇" title="Rückhand Zeigefinger nach unten" aria-label="Emoji: Rückhand Zeigefinger nach unten">
Virus -, Ab -, skin +

https://twitter.com/EricTopol/status/1294057740076081152">https://twitter.com/EricTopol...

and goes back to the when we don& #39;t measure thread https://twitter.com/erictopol/status/1278400526716211200?lang=en">https://twitter.com/erictopol...

A tipoff from April were the 2 patients reported without antibodies (X-linked agammaglobulinemia) who fully recovered from covid
https://onlinelibrary.wiley.com/doi/epdf/10.1111/pai.13263">https://onlinelibrary.wiley.com/doi/epdf/...