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Just published @CellCellPress
"SARS-CoV-2 elicits robust, broad and highly functional memory T cell responses, suggesting that natural exposure or infection may prevent recurrent episodes of severe COVID-19" https://www.cell.com/cell/fulltext/S0092-8674(20)31008-4?rss=yes by @karolinskainst
"SARS-CoV-2 elicits robust, broad and highly functional memory T cell responses, suggesting that natural exposure or infection may prevent recurrent episodes of severe COVID-19" https://www.cell.com/cell/fulltext/S0092-8674(20)31008-4?rss=yes by @karolinskainst
Unique, full spectrum study of acute and convalescent patients, family members exposed but seronegative, healthy unexposed
SARSCoV2 specific T cells present even in asymptomatic individuals, mild cases, and antibody-negative family members exposed
Important findings!
SARSCoV2 specific T cells present even in asymptomatic individuals, mild cases, and antibody-negative family members exposed
Important findings!
The dissociation of antibody (its absence) and a robust T cell response is noteworthy.
It reinforces how much we miss by focusing on antibodies out of convenience, since T cells response is only assessed in research labs
Connects w yesterday's case report
Virus -, Ab -, skin +
It reinforces how much we miss by focusing on antibodies out of convenience, since T cells response is only assessed in research labs
Connects w yesterday's case report
Virus -, Ab -, skin +
and goes back to the when we don't measure thread https://twitter.com/erictopol/status/1278400526716211200?lang=en
A tipoff from April were the 2 patients reported without antibodies (X-linked agammaglobulinemia) who fully recovered from covid
https://onlinelibrary.wiley.com/doi/epdf/10.1111/pai.13263
https://onlinelibrary.wiley.com/doi/epdf/10.1111/pai.13263
