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@UniofOxford @AstraZeneca COVID vaccine (modified chimp adenovirus bearing spike protein) effective!
Dose regimen 1 (1/2 dose + full dose): 90%
Dose regimen 2 (full + full): 62%
Avg regimens: 70%
Interim analysis 11K, 131 events
Fridge temp storage https://www.astrazeneca.com/media-centre/press-releases/2020/azd1222hlr.html
Dose regimen 1 (1/2 dose + full dose): 90%
Dose regimen 2 (full + full): 62%
Avg regimens: 70%
Interim analysis 11K, 131 events
Fridge temp storage https://www.astrazeneca.com/media-centre/press-releases/2020/azd1222hlr.html
Did investigators expect 1/2 + full to outperform full + full?
Is there a scientific rationale for that?
Also, for either regimen, best news:
“Among those who received the vaccine, there were no severe cases of Covid-19 in the trial and no participants were hospitalized.“
Is there a scientific rationale for that?
Also, for either regimen, best news:
“Among those who received the vaccine, there were no severe cases of Covid-19 in the trial and no participants were hospitalized.“
vaccine that much of developing world has bought
“Oxford accounts for more than 40% of supplies going to those countries...costs a fraction of price set by Pfizer and will be manufactured in multiple countries, from India to Brazil...easier to deploy”
https://www.bloomberg.com/amp/news/articles/2020-11-22/astra-oxford-shot-is-key-to-escaping-pandemic-for-many-nations?__twitter_impression=true
“Oxford accounts for more than 40% of supplies going to those countries...costs a fraction of price set by Pfizer and will be manufactured in multiple countries, from India to Brazil...easier to deploy”
https://www.bloomberg.com/amp/news/articles/2020-11-22/astra-oxford-shot-is-key-to-escaping-pandemic-for-many-nations?__twitter_impression=true
Global order tracking 
, fascinatingOxford did say vaccine may prevent asymptomatic infections...
Pfizer/Moderna couldn't assess this
h/t @sciencescanner https://twitter.com/simonbayly/status/1330822021903691776
reminds me that clinical trial efficacy top line number is often about ENDPOINTS chosen https://twitter.com/simonbayly/status/1330822021903691776
@simonbayly looking a further into this. am not sure about your claim.
here is @EricTopol summary of the *primary endpoints* of the 3 trials. Looks like @AstraZeneca primary endpoint included symptoms
cc: @sciencescanner https://twitter.com/EricTopol/status/1307408470245691392
here is @EricTopol summary of the *primary endpoints* of the 3 trials. Looks like @AstraZeneca primary endpoint included symptoms
cc: @sciencescanner https://twitter.com/EricTopol/status/1307408470245691392