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(1/7) A framework for understanding post-acute #COVID19 / #LongCOVID 
https://academic.oup.com/ofid/advance-article/doi/10.1093/ofid/ofaa509/5934556
#IDtwitter #MedTwitter #publichealth #publichealthtwitter
https://academic.oup.com/ofid/advance-article/doi/10.1093/ofid/ofaa509/5934556
#IDtwitter #MedTwitter #publichealth #publichealthtwitter
(2/7) Post-acute #COVID19 can be divided into 3 categories:
(1) Persistent symptoms >3 wks after initial infxn
(2) Persistent organ dysfunction >3 wks after initial infxn
(If patient remains hospitalized, the post-acute period can start at time of discharge from acute care)
(1) Persistent symptoms >3 wks after initial infxn
(2) Persistent organ dysfunction >3 wks after initial infxn
(If patient remains hospitalized, the post-acute period can start at time of discharge from acute care)
(3/7)
(3) Novel approach to classifying multisystem inflammatory syndrome as a post-acute or post-infectious primarily inflammatory entity after initial asymptomatic or mild #COVID19 infection
(3) Novel approach to classifying multisystem inflammatory syndrome as a post-acute or post-infectious primarily inflammatory entity after initial asymptomatic or mild #COVID19 infection
(4/7) Persistent organ dysfunction divided into following categories:
Pulmonary sequelae
Cardiac sequelae
Thromboembolic sequelae
Neurologic sequelae
Renal sequelae
Potential rehabilitation requirements
Pulmonary sequelae
Cardiac sequelae
Thromboembolic sequelae
Neurologic sequelae
Renal sequelae
Potential rehabilitation requirements
(5/7) We also discuss post-acute clinical syndromes in other epidemic coronaviruses (SARS-CoV-1 and MERS-CoV) and potential mechanisms driving the phenomenon of post-acute #COVID19.
(6/7) Potential mechanisms driving #COVID19 include: direct neuroinvasion; dysregulated immune response/auto-immunity; lingering virus in immunologically privileged sites; endothelial damage; post-ICU syndrome.
(7/7) Finally, there can be interplay between persistent symptoms and persistent organ dysfunction, as noted in figure above.
#LongCovid #COVID19
@EvaAmenta @A_Spallonii @bbchealth
https://academic.oup.com/ofid/advance-article/doi/10.1093/ofid/ofaa509/5934556
#LongCovid #COVID19
@EvaAmenta @A_Spallonii @bbchealth
https://academic.oup.com/ofid/advance-article/doi/10.1093/ofid/ofaa509/5934556
@ABsteward -- thought you might be interested in our paper released just today. Thanks!
@JaclynAlbin -- thought you might be interested in our paper!
@ShohamTxID @FranciscoMarty_ -- Dr. Shoham and Dr. Marty -- I thought you all might be interested in our manuscript released earlier today and which I describe in this Twitter thread given your expertise in #COVID19. Thanks!
https://academic.oup.com/ofid/advance-article/doi/10.1093/ofid/ofaa509/5934556
https://academic.oup.com/ofid/advance-article/doi/10.1093/ofid/ofaa509/5934556
@jbcowartmd — thought you might be interested in our article that was published online today!
