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Ever wondered how #glycan chains are synthesised in #EukaryoticCells?
It’s just like building #Lego models step by step!
Read more about @thattai & @anjali_jaiman’s incredible journey to deduce the details of this process:
https://theory.ncbs.res.in/news/building-biomolecules-one-step-time
#AlgorithmicSynthesis
It’s just like building #Lego models step by step!
Read more about @thattai & @anjali_jaiman’s incredible journey to deduce the details of this process:
https://theory.ncbs.res.in/news/building-biomolecules-one-step-time
#AlgorithmicSynthesis
Cellular #enzymes, like those responsible for building glycans, are sloppy & make mistakes frequently!
Despite this, only a small range of glycan chains are found to be associated with a specific #protein!
How is the #variability of glycan chains so tightly-controlled in cells?
Despite this, only a small range of glycan chains are found to be associated with a specific #protein!
How is the #variability of glycan chains so tightly-controlled in cells?
In their recent @eLife paper, @thattai & @anjali_jaiman answer this question using careful #mathematical reasoning!
They show that partitioning these sloppy enzymes across multiple compartments of the #Golgi is key to controlling the assembly of glycans. http://elifesciences.org/articles/49573
They show that partitioning these sloppy enzymes across multiple compartments of the #Golgi is key to controlling the assembly of glycans. http://elifesciences.org/articles/49573
The study shows that multi-compartment synthesis can greatly increase the range of glycan chains a cell can specifically produce!
Read more about their journey in this piece by @SiddhrthKnkaria, with illustrations by @dhanya_bharath!
#SciComm #SciArt
https://theory.ncbs.res.in/news/building-biomolecules-one-step-time
Read more about their journey in this piece by @SiddhrthKnkaria, with illustrations by @dhanya_bharath!
#SciComm #SciArt
https://theory.ncbs.res.in/news/building-biomolecules-one-step-time
Read more about their study,
"Golgi compartments enable controlled biomolecular assembly using promiscuous enzymes"
in this thread by Dr. Mukund Thattai: https://twitter.com/thattai/status/1277588401152114689
"Golgi compartments enable controlled biomolecular assembly using promiscuous enzymes"
in this thread by Dr. Mukund Thattai: https://twitter.com/thattai/status/1277588401152114689
