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THREAD from the new #bradykinin research (pre-print) from 
:
"We propose that the severity of the disease and many deaths are due to a local vascular problem due to activation of B1 receptors on #endothelial cells in the lungs."
#COVID19 #kinins
https://www.preprints.org/manuscript/202004.0023/v1
:"We propose that the severity of the disease and many deaths are due to a local vascular problem due to activation of B1 receptors on #endothelial cells in the lungs."
#COVID19 #kinins
https://www.preprints.org/manuscript/202004.0023/v1
"the B1 receptor on endothelial cells is upregulated by proinflammatory #cytokines Without #ACE2 acting as a guardian to inactivate the ligands of B1, the lung environment is prone for local vascular leakage leading to #angioedema"...
#bradykinin #COVID19
"... and might explain the typical #CTscans and the feeling of people that they drown.In some pt., this is followed by a clinical worsening of disease around day 9 due to the formation antibodies directed against the spike (S)-antigen of #SARSCoV2 that binds to #ACE2"
"inflammation induces more B1 expression, & possibly via antibody-dependent enhancement of viral infection leading to continued #ACE2 dysfunction in the lung."we propose that a #bradykinin -dependent local lung angioedema via B1/B2 receptors is an imp. feature of #COVID19."
/more from the full PDF/ #bradykinin #COVID19
"Importantly, we observed that #dyspnea and #tachypnea can differ from hour to hour and a feeling of drowning is described with sometimes sudden
recovery by patients."
"Importantly, we observed that #dyspnea and #tachypnea can differ from hour to hour and a feeling of drowning is described with sometimes sudden
recovery by patients."
#bradykinin #COVID19
"Notably, plasma concentrations of D-dimers at this stage are increased without evidence of thromboembolic
events."
"This worsening seems to be accompanied specifically with further increases in #IL6, CRP, #ferritin,
without elevated procalcitonin."
"Notably, plasma concentrations of D-dimers at this stage are increased without evidence of thromboembolic
events."
"This worsening seems to be accompanied specifically with further increases in #IL6, CRP, #ferritin,
without elevated procalcitonin."
#bradykinin #COVID19
"Furthermore, PEEP shows poor recruitability in most patients. Hereby mechanical #ventilation may further
contribute to #lungdamage. Pulmonary hypertension is not an important clinical component."
"Furthermore, PEEP shows poor recruitability in most patients. Hereby mechanical #ventilation may further
contribute to #lungdamage. Pulmonary hypertension is not an important clinical component."
"We propose it all starts with ACE2 & its role in the kallikrein-kinin system, which to date has not investigated in the pathogenesis of #SARS or #COVID19.
The clinical picture is in line with a single-organ failure of the #lung that is due to edema at the site of inflammation."
The clinical picture is in line with a single-organ failure of the #lung that is due to edema at the site of inflammation."
#bradykinin
"This most likely reflects the leakage of plasma substances involved in the coagulation cascade leading to fibrin & due to kallikrein activity is processed into D-dimer & leaks back into the circulation, reflecting subendothelial activation and kallikrein activity."
"This most likely reflects the leakage of plasma substances involved in the coagulation cascade leading to fibrin & due to kallikrein activity is processed into D-dimer & leaks back into the circulation, reflecting subendothelial activation and kallikrein activity."
#bradykinin
"Pulmonary edema by ACE2 dysfunction was speculated to be due to increased hydrostatic pressure as a result of vasoconstriction of the pulmonary vasculature due to high angiotensin II (a vasoconstrictor).
However, further experiments showed no difference ..."
"Pulmonary edema by ACE2 dysfunction was speculated to be due to increased hydrostatic pressure as a result of vasoconstriction of the pulmonary vasculature due to high angiotensin II (a vasoconstrictor).
However, further experiments showed no difference ..."
"Increased #bradykinin however could explain this observation without increased hydrostatic pressure. Notably, the RAS system controls vasoconstriction and vasodilatation, and the bradykinin system controls permeability and vasodilatation, whereas #ACE2 regulates both." #COVID19
END THREAD
is to the end of Page 5. There are 11 pages + 7 pages of references and figures.
Just seems like an intriguing observation, and many of the comments on preprint site reflect interest in delving deeper.
https://www.preprints.org/manuscript/202004.0023/v1
#COVID19 #bradykinin /theory/
is to the end of Page 5. There are 11 pages + 7 pages of references and figures. Just seems like an intriguing observation, and many of the comments on preprint site reflect interest in delving deeper.
https://www.preprints.org/manuscript/202004.0023/v1
#COVID19 #bradykinin
/theory/
