I find it easiest to interact with tweets from accounts I've never seen before and will probably never see again. The least amount of thought goes into those tweets.

When it's accounts I know/follow, I try my best not only to be respectful, but to make sure there's no/little space to come of as disrespectful.

Now, the point of this thread is those accounts that I know very well, and because of that reason, will never interact with their tweets. It's not malice, I just see them as being on the other side of a very thick glass wall. And I'm fine with that.