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Watching—South Africa
https://abs.twimg.com/emoji/v2/... draggable="false" alt="🇿🇦" title="Vlag van Zuid-Afrika" aria-label="Emoji: Vlag van Zuid-Afrika"> may have a new subvariant, 66% dominant—the BA2+L452R group is a #BA2 subtype that mixes with an infamously bad L452R mutation, found in Delta/Kappa/Lambda, & known to make #SARSCoV2 more infective & severe. https://abs.twimg.com/emoji/v2/... draggable="false" alt="🇫🇷" title="Vlag van Frankrijk" aria-label="Emoji: Vlag van Frankrijk">sees early uptick too.
https://cov-spectrum.org/explore/South%20Africa/AllSamples/Past6M/variants/international-comparison?aaMutations=S%3AL452R&pangoLineage=BA.2*&">https://cov-spectrum.org/explore/S...
https://cov-spectrum.org/explore/South%20Africa/AllSamples/Past6M/variants/international-comparison?aaMutations=S%3AL452R&pangoLineage=BA.2*&">https://cov-spectrum.org/explore/S...
may have a new subvariant, 66% dominant—the BA2+L452R group is a #BA2 subtype that mixes with an infamously bad L452R mutation, found in Delta/Kappa/Lambda, & known to make #SARSCoV2 more infective & severe. https://abs.twimg.com/emoji/v2/... draggable="false" alt="🇫🇷" title="Vlag van Frankrijk" aria-label="Emoji: Vlag van Frankrijk">sees early uptick too. https://cov-spectrum.org/explore/S..." title="Watching—South Africahttps://abs.twimg.com/emoji/v2/... draggable="false" alt="🇿🇦" title="Vlag van Zuid-Afrika" aria-label="Emoji: Vlag van Zuid-Afrika"> may have a new subvariant, 66% dominant—the BA2+L452R group is a #BA2 subtype that mixes with an infamously bad L452R mutation, found in Delta/Kappa/Lambda, & known to make #SARSCoV2 more infective & severe. https://abs.twimg.com/emoji/v2/... draggable="false" alt="🇫🇷" title="Vlag van Frankrijk" aria-label="Emoji: Vlag van Frankrijk">sees early uptick too. https://cov-spectrum.org/explore/S...">
may have a new subvariant, 66% dominant—the BA2+L452R group is a #BA2 subtype that mixes with an infamously bad L452R mutation, found in Delta/Kappa/Lambda, & known to make #SARSCoV2 more infective & severe. https://abs.twimg.com/emoji/v2/... draggable="false" alt="🇫🇷" title="Vlag van Frankrijk" aria-label="Emoji: Vlag van Frankrijk">sees early uptick too. https://cov-spectrum.org/explore/S..." title="Watching—South Africahttps://abs.twimg.com/emoji/v2/... draggable="false" alt="🇿🇦" title="Vlag van Zuid-Afrika" aria-label="Emoji: Vlag van Zuid-Afrika"> may have a new subvariant, 66% dominant—the BA2+L452R group is a #BA2 subtype that mixes with an infamously bad L452R mutation, found in Delta/Kappa/Lambda, & known to make #SARSCoV2 more infective & severe. https://abs.twimg.com/emoji/v2/... draggable="false" alt="🇫🇷" title="Vlag van Frankrijk" aria-label="Emoji: Vlag van Frankrijk">sees early uptick too. https://cov-spectrum.org/explore/S...">
2) the L452R — “Based on genome-wide phylogenetic analysis, emergence of both viral variants was specifically triggered by acquisition of L452R, suggesting a strong positive selection for this mutation.” https://journals.asm.org/doi/10.1128/JCM.00921-21">https://journals.asm.org/doi/10.11...
3) “L452 is in immediate proximity to ACE2 interaction interface—L452R mutation is associated with immune escape & could result in a stronger cell attachment of virus, with both factors likely increasing viral transmissibility, infectivity, pathogenicity.” https://journals.asm.org/doi/10.1128/JCM.00921-21">https://journals.asm.org/doi/10.11...
4) And yes, I want to emphasize that the variant may not necessarily be from South Africa https://abs.twimg.com/emoji/v2/... draggable="false" alt="🇿🇦" title="Vlag van Zuid-Afrika" aria-label="Emoji: Vlag van Zuid-Afrika"> per se… but it clearly is the first country to see BA2+L452R become dominant. These kinds of curves are never a good sign.
per se… but it clearly is the first country to see BA2+L452R become dominant. These kinds of curves are never a good sign." title="4) And yes, I want to emphasize that the variant may not necessarily be from South Africa https://abs.twimg.com/emoji/v2/... draggable="false" alt="🇿🇦" title="Vlag van Zuid-Afrika" aria-label="Emoji: Vlag van Zuid-Afrika"> per se… but it clearly is the first country to see BA2+L452R become dominant. These kinds of curves are never a good sign." class="img-responsive" style="max-width:100%;"/>
5) Moreover, we know from recent mice study that Omicron-L452R variant strengthened the high infectivity. “Notably, Omicron-L452R greatly enhanced the ability of Omicron to infect lung tissues of humanized ACE2 mice.” https://www.nature.com/articles/s41392-022-00941-z">https://www.nature.com/articles/...
6) And no, this is not even “XE”… XE is a mixture of BA1 and BA2. It’s slightly more contagious but I’m still waiting and holding off alarm bells on XE for a little bit longer. This BA2+L452R is different group.
https://medriva.com/what-is-the-omicron-xe-variant-and-why-are-scientists-concerned-about-their-rapid-transmission-rates-fueling-the-uk/">https://medriva.com/what-is-t...
https://medriva.com/what-is-the-omicron-xe-variant-and-why-are-scientists-concerned-about-their-rapid-transmission-rates-fueling-the-uk/">https://medriva.com/what-is-t...
