Read on Twitter
WIP thread noting all the potential problems noted with the TOGETHER manuscript. 
These are being worked through by various people, and some of them will have good explanations. Gathering them here to keep track.
Reply to this first tweet with issues I may have missed.
These are being worked through by various people, and some of them will have good explanations. Gathering them here to keep track.
Reply to this first tweet with issues I may have missed.
Let's start with the mistaken sums.
1. A death moving between treatment and placebo. https://twitter.com/sudokuvariante/status/1509452834730827780?t=gxlyYobF155En05LOWop6Q&s=19
1. A death moving between treatment and placebo. https://twitter.com/sudokuvariante/status/1509452834730827780?t=gxlyYobF155En05LOWop6Q&s=19
2. Magic fifties. https://twitter.com/MaryKRe/status/1509623217065013258?t=gxlyYobF155En05LOWop6Q&s=19
Is this nitpicking? I don't know. What I do know is that in the case of Carvallo, such mistaken sums in figures were considered evidence of FWAWD!! https://www.buzzfeednews.com/article/stephaniemlee/ivermectin-covid-study-suspect-data
4. Underdosing those over 90kg: https://twitter.com/alexandrosM/status/1510075920106762243?t=ZV8QUluHn_lakuSZ7ZMmbQ&s=19
5. Biased dropped events? https://twitter.com/mmpaquette/status/1509579476413210665?t=t1jjJr-AR7LtvZt7xs-yWw&s=19
6. Mentioning exclusions in the discussion section but not in the exclusion section or the protocol. https://twitter.com/alexandrosM/status/1509431705777565698?s=20&t=c3_9Eocc6m3JT3o2CME5Iw
7. More data slop. https://twitter.com/MaryKRe/status/1510096719379316736?t=wiZ5kWU6zpkRRPZ3EyNQoQ&s=19
8. By advising taking the medication on an empty stomach, plasma levels never reached the threshold required to show an effect: https://twitter.com/Amabiel1/status/1509292304951123970?t=i9QADZfSpptxUqQ6C3Vlnw&s=19
9. Violating its stated randomization protocol, the trial seems to have engaged in "catch-up" enrollment around the time it reset the dosing (and just as Gamma variant was ascendant) - https://longhaulwiki.com/resources/assets/Numerous%20issues%20with%20the%20TOGETHER%20trial.pdf
10. Another serious, potentially lethal issue: Including contraindicated patients. https://ivmmeta.com/#togetherivm
11. Lots of missing data, results, and analyses that were either promised in the protocol, or provided for other studies done in the context of the same trial. https://ivmmeta.com/#togetherivm
12. There is a huge lack of clarity whether vaccinated patients were allowed into the trial, and from when. There seems to have been no attempt to balance vaccination status in treatment/control? https://twitter.com/millenamos/status/1509442036662898688?t=dVZMS5pdpDOjwl95UssPRA&s=19
13. The patients with missing time from onset seem to be having particularly great results.
14. Was it improperly terminated? https://twitter.com/alexandrosM/status/1510765353462239232?t=mGfhhPuvmVTGUi_HZr2zVw&s=19
15. Were the results misrepresented? https://twitter.com/alexandrosM/status/1510741181759574017
16. Protocol Violating Multiple Imputation
Authors claimed in the protocol that the technique would be used to fill at most 20% missing values, and yet for Time Since Symptom Onset in Table 1 they applied it for 317 values, or just over 23%.
Authors claimed in the protocol that the technique would be used to fill at most 20% missing values, and yet for Time Since Symptom Onset in Table 1 they applied it for 317 values, or just over 23%.
17. The Data and Safety Monitoring Committee was claimed to have no involvement in the protocol, but obviously did. https://twitter.com/alexandrosM/status/1511612742351798276?t=ldRVuPISH9TJRdJgjwoO7Q&s=19
18. The data sharing agreement keeps getting altered... https://twitter.com/alexandrosM/status/1511651836297576451?t=ldRVuPISH9TJRdJgjwoO7Q&s=19
19. Two ethics violations. The second one in particular has me fuming if true. https://twitter.com/alexandrosM/status/1512180745653026833?t=Gftsb5iL2z1lF67dmbwpTw&s=19
20. Why did the acceptance rate of patients go from 53% in the first 3 months of 2021 to 27% in the next 4? https://twitter.com/alexandrosM/status/1512792713489387523?t=iHSdxDs6vKYPKOVoLGVaxg&s=19
I'm starting to get a sense of what is happening. My first attempt at explaining it is here, but it's not complete yet. https://twitter.com/alexandrosM/status/1512452800181317633?t=SLki-paU2--wdiutzARn_A&s=19
The truth is staring us in the face, right here.
