Thread by @TXstillWatching, Shedding...plausible process by which it could occur through the release of exosomes [...]

Shedding...
plausible process by which it could occur through the release of exosomes from dendritic cells in the spleen containing misfolded spike proteins, in complex with other prion reconformed proteins. These exosomes can travel to distant places. https://twitter.com/9KUSATHINKS/status/1484215543251017733">https://twitter.com/9KUSATHIN...

https://twitter.com/VeritasTXgem/status/1401284950809325570/photo/1

Through the release of exosomes from dendritic cells in the spleen containing misfolded spike proteins, in complex with other prion reconformed proteins. These exosomes can travel to distant places.

It is not impossible to imagine that they are being released from the lungs and inhaled by a nearby person.

Extracellular vesicles, including exosomes, have been detected in sputum, mucus, epithelial lining fluid, and bronchoalveolar lavage fluid in association with respiratory diseases (Lucchetti et al., 2021).

https://abs.twimg.com/emoji/v2/... draggable="false" alt="📑" title="Bladwijzer" aria-label="Emoji: Bladwijzer">

https://abs.twimg.com/emoji/v2/... draggable="false" alt="🔗" title="Link symbool" aria-label="Emoji: Link symbool"> https://www.doi.org/10.1183/13993003.03024-2020">https://www.doi.org/10.1183/1...

Detection and characterisation of extracellular vesicles in exhaled breath condensate and sputum of...

Small and medium extracellular vesicles, identified and characterised in exhaled breath condensate and induced sputum supernatants, might provide pathophysiological insights and novel biomarkers in...

https://www.doi.org/10.1183/13993003.03024-2020

H/t @Clucky92864053
Studies that show that Spike protein ends up in exosomes which will then be consumed by phagocytes...

https://biosignaling.biomedcentral.com/articles/10.1186/s12964-021-00730-1">https://biosignaling.biomedcentral.com/articles/... https://twitter.com/Clucky92864053/status/1484276379092987904">https://twitter.com/Clucky928...

A Phase 1/2/3 study undertaken by BioNTech on the Pfizer mRNA vaccine implied in their study protocol that they anticipated the possibility of secondary exposure to the vaccine (BioNTech, 2020).

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https://abs.twimg.com/emoji/v2/... draggable="false" alt="🔗" title="Link symbool" aria-label="Emoji: Link symbool"> https://media.tghn.org/medialibrary/2020/11/C4591001_Clinical_Protocol_Nov2020_Pfizer_BioNTech.pdf">https://media.tghn.org/medialibr...

The protocol included the requirement that “exposure during pregnancy” should be reported by the study participants. They then gave examples of “environmental exposure during pregnancy” which included exposure “to the study intervention by inhalation or skin contact.”

They even suggested two levels of indirect exposure: “A male family member or healthcare provider who has been exposed to the study intervention by inhalation or skin contact then exposes his female partner
prior to or around the time of conception.”

‘Leaky’

https://abs.twimg.com/emoji/v2/... draggable="false" alt="💉" title="Injectiespuit" aria-label="Emoji: Injectiespuit"> Can Produce Stronger Versions of Viruses

These less-than-perfect

https://abs.twimg.com/emoji/v2/... draggable="false" alt="💉" title="Injectiespuit" aria-label="Emoji: Injectiespuit">s create a “leaky” barrier against the virus.

https://abs.twimg.com/emoji/v2/... draggable="false" alt="💉" title="Injectiespuit" aria-label="Emoji: Injectiespuit">ed individuals may get sick but have less severe symptoms, but the virus survives long enough to transmit to others, which allows it to survive and spread throughout a population.

Imperfect Vaccination Can Enhance the
Transmission of Highly Virulent Pathogens
But when vaccines leak, allowing at least some pathogen transmission, they could create the ecological conditions that would allow hot strains to emerge and persist.

https://abs.twimg.com/emoji/v2/... draggable="false" alt="📑" title="Bladwijzer" aria-label="Emoji: Bladwijzer">

https://abs.twimg.com/emoji/v2/... draggable="false" alt="🔗" title="Link symbool" aria-label="Emoji: Link symbool"> https://journals.plos.org/plosbiology/article?id=10.1371/journal.pbio.1002198">https://journals.plos.org/plosbiolo...

Imperfect Vaccination Can Enhance the Transmission of Highly Virulent Pathogens

A study using Marek's disease virus in poultry shows that by reducing natural selection against highly virulent strains, imperfect vaccination enables the spread of viral strains that would otherwise...

https://journals.plos.org/plosbiology/article?id=10.1371/journal.pbio.1002198

Peron, J. P. S. & Nakaya, H. (2020). Susceptibility of the Elderly to SARS-CoV-2 Infection: ACE-2 Overexpression,
Shedding, and Antibody-dependent Enhancement (ADE). Clinics (Sao Paulo) 75: e1912.

https://abs.twimg.com/emoji/v2/... draggable="false" alt="📑" title="Bladwijzer" aria-label="Emoji: Bladwijzer">

https://abs.twimg.com/emoji/v2/... draggable="false" alt="🔗" title="Link symbool" aria-label="Emoji: Link symbool"> https://www.scielo.br/j/clin/a/QDXYJBQk6YyLpfGNgBKtxHQ/?lang=en">https://www.scielo.br/j/clin/a/...

Susceptibility of the Elderly to SARS-CoV-2 Infection: ACE-2 Overexpression, Shedding, and Antibo...

The world is currently facing a serious SARS-CoV-2 infection pandemic. This virus...

https://www.scielo.br/j/clin/a/QDXYJBQk6YyLpfGNgBKtxHQ/?lang=en

Johns Hopkins "Health Security" model: self amplifying/self spreading vax-eens https://www.medicdebate.org/taxonomy/term/4277">https://www.medicdebate.org/taxonomy/...

Self-amplifying mRNA vaccines https://pubmed.ncbi.nlm.nih.gov/25620012/ ">https://pubmed.ncbi.nlm.nih.gov/25620012/...

Self-amplifying mRNA vaccines - PubMed

This chapter provides a brief introduction to nucleic acid-based vaccines and recent research in developing self-amplifying mRNA vaccines. These vaccines promise the flexibility of plasmid DNA...

https://pubmed.ncbi.nlm.nih.gov/25620012/

Self-amplifying mRNA-Based Vaccine Technology and Its Mode of Action https://pubmed.ncbi.nlm.nih.gov/33861374/ ">https://pubmed.ncbi.nlm.nih.gov/33861374/...

Self-amplifying mRNA-Based Vaccine Technology and Its Mode of Action - PubMed

Self-amplifying mRNAs derived from the genomes of positive-strand RNA viruses have recently come into focus as a promising technology platform for vaccine development. Non-virally delivered self-am...

https://pubmed.ncbi.nlm.nih.gov/33861374/

Delivery of self-amplifying mRNA vaccines by cationic lipid nanoparticles: The impact of cationic lipid selection https://pubmed.ncbi.nlm.nih.gov/32619745/ ">https://pubmed.ncbi.nlm.nih.gov/32619745/...

Delivery of self-amplifying mRNA vaccines by cationic lipid nanoparticles: The impact of cationic...

Self-amplifying RNA (SAM) represents a versatile tool that can be used to develop potent vaccines, potentially able to elicit strong antigen-specific humoral and cellular-mediated immune responses to...

https://pubmed.ncbi.nlm.nih.gov/32619745/

Self-amplifying RNA vaccines for infectious diseases https://www.nature.com/articles/s41434-020-00204-y">https://www.nature.com/articles/...

Self-amplifying RNA vaccines for infectious diseases

Gene Therapy - Self-amplifying RNA vaccines for infectious diseases

https://www.nature.com/articles/s41434-020-00204-y

Self-disseminating vaccines for emerging infectious diseases https://www.ncbi.nlm.nih.gov/labs/pmc/articles/PMC4732410/">https://www.ncbi.nlm.nih.gov/labs/pmc/...

Self-disseminating vaccines for emerging infectious diseases

Modern human activity fueled by economic development is profoundly altering our relationship with microorganisms. This altered interaction with microbes is believed to be the major driving force...

https://www.ncbi.nlm.nih.gov/labs/pmc/articles/PMC4732410/

Self-Amplifying/Self-Spreading mRNA vaccines

https://www.medicdebate.org/files/johns-hopkins.pdf">https://www.medicdebate.org/files/joh...

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