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Y #Ivermectin doesn't work
1 #Ivermectin craze 4 #COVID19India started in South-America, spread like wildfire to USA/Europe. Heavily criticized in countries upholding #science, didnt find place in guidelines. BUT, nw it reached #India, into minds/hearts of doctors not due to...
1 #Ivermectin craze 4 #COVID19India started in South-America, spread like wildfire to USA/Europe. Heavily criticized in countries upholding #science, didnt find place in guidelines. BUT, nw it reached #India, into minds/hearts of doctors not due to...
2...the #science, but bcoz National institutions such as @aiims_newdelhi/ certain govts @goacm endorse it - without getting into the science of it. Nw, #ivermectin is slowly bcoming nationalist boy scout of #medicine in #India, wrngly endorsed by naïve students/senior professors.
3 Ivermectin is broad-spectrum antiparasitic approved by @US_FDA, proved to be safe at dose of ≤200 µg/kg. In a 60 kg man, the max conventional dose in 12 mg.
Caly et al (not Baba Ramdev) https://bit.ly/3vO9cuK identified in-vitro (cell study) anti- #SARSCoV2 ivermectin activity
Caly et al (not Baba Ramdev) https://bit.ly/3vO9cuK identified in-vitro (cell study) anti- #SARSCoV2 ivermectin activity
4 Tis was followd by in-silico studies (performed on computer or via computer simulation) tat showd potential of #ivermectin 4 inhibition of #coronavirus replication. Note tat these R all preclinical/cell based/computer-generated data/NOT real.
It can remain in 'valley of death'
It can remain in 'valley of death'
5 For #ivermectin 2 show #anticovid effect 0.5µM concentration is warranted. EVEN WITH dosing at 1700 µg/kg (nine times more than FDA approved/ = to 102 mg / V R using 12mg
) the 'effective' concentration of #ivermectin reached is only measly 0.28µM https://bpspubs.onlinelibrary.wiley.com/doi/10.1111/bcp.14476
) the 'effective' concentration of #ivermectin reached is only measly 0.28µM https://bpspubs.onlinelibrary.wiley.com/doi/10.1111/bcp.14476
6 So #scientific basis 4 assessing #ivermectin 4 #COVID19 at clinical level is insufficient. Wich is Y, @WHO excluded #ivermectin frm Solidarity Trial.
Watevr #ivermectin dosing is used in various studies (FLCCC or BIRD) or othr #ivermectincult grps is ACTUALLY #homeopathy level
Watevr #ivermectin dosing is used in various studies (FLCCC or BIRD) or othr #ivermectincult grps is ACTUALLY #homeopathy level
7 Nw in real life, A LOT of #ivermectin publications are mostly pre-prints, un-reviewed, unpublished and part of #ivermectin craze groups webpages/websites. This is not #science and quoting or linking these show the paucity in #scientific temper of the person sharing these.
8 Ther R SO MANY issues wit #ivermectin trials: published/unpublished
heterogeneity in patients receiving ivermectin (frm ICU patients to family contacts!/treating mild to ICU cases or even normal persons!
VERY differnt dosings
patients receiving various cointerventions...
heterogeneity in patients receiving ivermectin (frm ICU patients to family contacts!/treating mild to ICU cases or even normal persons!VERY differnt dosingspatients receiving various cointerventions...
9...control groups received different comparators ranging frm placebo to even #HydroxyChloroquine absolutely USELESS (but still prescribed by physicians like @drakchaurasia) drug for #COVID19
in gud pooled analyses, certainty of evidence was very low due 2 high risk of bias
control groups received different comparators ranging frm placebo to even #HydroxyChloroquine absolutely USELESS (but still prescribed by physicians like @drakchaurasia) drug for #COVID19in gud pooled analyses, certainty of evidence was very low due 2 high risk of bias
10 THE BIGGEST ISSUE -
Diff websites (such as https://ivmmeta.com/ , https://c19ivermectin.com/ , https://tratamientotemprano.org/estudios-ivermectina/) conduct low quality meta-analyses showing unpublished colourful graphs
2 deceive public
shared via social media
witout folowing any methodological guidelines
Diff websites (such as https://ivmmeta.com/ , https://c19ivermectin.com/ , https://tratamientotemprano.org/estudios-ivermectina/) conduct low quality meta-analyses showing unpublished colourful graphs
2 deceive public
shared via social media
witout folowing any methodological guidelines
11
One such, FLCCC is a fraud, grifter [someone who cheats others out of money/ also known as chiselers, defrauders, gougers, scammers, swindlers] organization wich publish #ivermectin data on their webpage, fleece people of their hard earned money, unleashing radicalization...
![11One such, FLCCC is a fraud, grifter [someone who cheats others out of money/ also known as chiselers, defrauders, gougers, scammers, swindlers] organization wich publish #ivermectin data on their webpage, fleece people of their hard earned money, unleashing radicalization...](https://pbs.twimg.com/media/E1EoPDvVoAAiR9e.jpg "11One such, FLCCC is a fraud, grifter [someone who cheats others out of money/ also known as chiselers, defrauders, gougers, scammers, swindlers] organization wich publish #ivermectin data on their webpage, fleece people of their hard earned money, unleashing radicalization...")
One such, FLCCC is a fraud, grifter [someone who cheats others out of money/ also known as chiselers, defrauders, gougers, scammers, swindlers] organization wich publish #ivermectin data on their webpage, fleece people of their hard earned money, unleashing radicalization...
12...their recent low class, third rate publication on #ivermectin (wich they claim is effective thru poor and biased analysis) is currently the 'holy grail' for #ivemectin quacks in #India.
This publication is utter nonsense and has been debunked here
https://twitter.com/drabbyphilips/status/1391055035652468738?s=20
This publication is utter nonsense and has been debunked here
https://twitter.com/drabbyphilips/status/1391055035652468738?s=20
13
These group based website analyses are full of errors and misleading claims.
No protocol registration
No methods, search strategies, inclusion criteria
No quality assessment of the included studies
No certainty of the evidence of pooled estimates
These group based website analyses are full of errors and misleading claims.
No protocol registrationNo methods, search strategies, inclusion criteriaNo quality assessment of the included studiesNo certainty of the evidence of pooled estimates
14
These websites ARE THE MAIN REASON for confusion among clinicians, patients and even decision-makers. An issue when performing metanalyses wich R not based on rigorous systematic reviews
Leading to spread spurious or fallacious findings - wich further damage #scientific temper
These websites ARE THE MAIN REASON for confusion among clinicians, patients and even decision-makers. An issue when performing metanalyses wich R not based on rigorous systematic reviews
Leading to spread spurious or fallacious findings - wich further damage #scientific temper
15
Also understand that #ivermectin controversy has politicisized and divided the medical community in certain countries.
https://www.bmj.com/content/373/bmj.n747
Doctors MUST be scientists wich ensures adequate knowledge in processing information and preventing unecessary prescriptions.
Also understand that #ivermectin controversy has politicisized and divided the medical community in certain countries.
https://www.bmj.com/content/373/bmj.n747
Doctors MUST be scientists wich ensures adequate knowledge in processing information and preventing unecessary prescriptions.
16
Lot of my discussion is taken frm this excellent paper https://ebm.bmj.com/content/early/2021/04/21/bmjebm-2021-111678#ref-26
To conclude #ivermectin is USELESS 4 #COVID19India/MUST not be promoted
@pash22 @AnooBhu @malini_aisola @dawalelo @just1doctorwala @GorwayGlobal @deralteGaukler @drkamnakakkar
Lot of my discussion is taken frm this excellent paper https://ebm.bmj.com/content/early/2021/04/21/bmjebm-2021-111678#ref-26
To conclude #ivermectin is USELESS 4 #COVID19India/MUST not be promoted
@pash22 @AnooBhu @malini_aisola @dawalelo @just1doctorwala @GorwayGlobal @deralteGaukler @drkamnakakkar
17 Here R som more imp links showcasing poor measures in #ivermectin promotion including data fraud to show benefits!
https://twitter.com/paimadhu/status/1391797231213322247?s=20
https://twitter.com/donnghaile/status/1391827759421394948?s=20
https://www.fda.gov/consumers/consumer-updates/why-you-should-not-use-ivermectin-treat-or-prevent-covid-19
Promotion of #ivermectin thru The Weather Channel
https://twitter.com/aaronhoyland/status/1391092125119385603?s=20
End
https://twitter.com/paimadhu/status/1391797231213322247?s=20
https://twitter.com/donnghaile/status/1391827759421394948?s=20
https://www.fda.gov/consumers/consumer-updates/why-you-should-not-use-ivermectin-treat-or-prevent-covid-19
Promotion of #ivermectin thru The Weather Channel
https://twitter.com/aaronhoyland/status/1391092125119385603?s=20End
18
For proper, realistic, high quality, validated analysis on all treatments for #COVID19India, plz see
http://www.covid-nma.com which is run collaboratively by the best research organization of the world, not grifter organizations like FLCCC and BIRD etc...
For proper, realistic, high quality, validated analysis on all treatments for #COVID19India, plz see
http://www.covid-nma.com which is run collaboratively by the best research organization of the world, not grifter organizations like FLCCC and BIRD etc...
19
Here is wat #scientific societies with evidence based analysis say about #Ivermectin
https://twitter.com/drabbyphilips/status/1390639555452149762?s=20
Here is wat #scientific societies with evidence based analysis say about #Ivermectin
https://twitter.com/drabbyphilips/status/1390639555452149762?s=20
