Q: How hard is it to model covid cases in the future?
A: Very hard.
This CDC paper on modeling scenarios on vaccine efficacy/uptake and NPIs has gotten its share of Twitticule:
https://www.cdc.gov/mmwr/volumes/70/wr/mm7019e3.htm?s_cid=mm7019e3_w
It was well outside its 50% "prediction interval" before even being published!
This is not inherently terrible.
Ppl who predicted the Chiefs would win the Super Bowl by >3 points were not fools;
they just underestimated how outmatched their OL would be.
But if I published a paper IN MARCH about how the Chiefs should've won the Super Bowl by more than 3...
I'd probably acknowledge the flawed parts of my analysis before advancing a model telling you to take the Chiefs at 6:1 to win the next Super Bowl.
Not much "acknowledging" happening with this paper.
Govts and institutions rely on models to make decisions for the future, now.
So - I get asked a lot by patients, "What's going to happen with this pandemic?"
I have no idea, because I keep being surprised.
I did not see that little wave in late March'21 coming.
But if I had to guess...
While it's clear that CDC ensemble model over-rated the case rise in March;
I fear they are far too optimistic for the rest.
And I cannot endorse that their projection interval gets smaller as the time gets further out!
I expect a push-pull between immunity, behavior&seasonality.
Summer brings on A/C gatherings.
Fall brings cooler, drier air and schools.
All the while, NPIs will be falling.
And maybe a variant like P.1.351 shakes up immunity and R0? Maybe vaccines peak w/in 6 months and natural immunity drops within a year, too?
So many variables 🤔
I'd be very reluctant to predict very low levels through summer and fall.
I hope I'm wrong - but wouldn't be surprised to see cases >50K/d for long stretches between summer and next spring.
And... better to take the Steelers at 30:1.
Pls don't remind me of this thread next year.
You can follow @buzzhollandermd.
Tip: mention @twtextapp on a Twitter thread with the keyword “unroll” to get a link to it.

Latest Threads Unrolled: