#FERRITIN is being widely ordered these days. Let& #39;s dive into the details and learn more about this protein. A short thread for those interested. Covers some history, biology and practical aspects about FERRITIN.
1/n
1/n
It was discovered in 1937 by Laufbérger but it wasn& #39;t until 1972 that an assay was devised to measure serum ferritin.
Ferritin is present in 2 forms
https://abs.twimg.com/emoji/v2/... draggable="false" alt="👉" title="Rückhand Zeigefinger nach rechts" aria-label="Emoji: Rückhand Zeigefinger nach rechts"> Intra-cellular (in the cytosol)
https://abs.twimg.com/emoji/v2/... draggable="false" alt="👉" title="Rückhand Zeigefinger nach rechts" aria-label="Emoji: Rückhand Zeigefinger nach rechts"> Extra-cellular
2/n
Ferritin is present in 2 forms
2/n
It is a ~450kDa protein.
Has 24 subunits of 2 major types
https://abs.twimg.com/emoji/v2/... draggable="false" alt="👉" title="Rückhand Zeigefinger nach rechts" aria-label="Emoji: Rückhand Zeigefinger nach rechts"> H : gene on chr 11q
https://abs.twimg.com/emoji/v2/... draggable="false" alt="👉" title="Rückhand Zeigefinger nach rechts" aria-label="Emoji: Rückhand Zeigefinger nach rechts"> L : gene on chr 19q
Serum ferritin has
https://abs.twimg.com/emoji/v2/... draggable="false" alt="⬆️" title="Pfeil nach oben" aria-label="Emoji: Pfeil nach oben"> L: H ratio.
3/n
Has 24 subunits of 2 major types
Serum ferritin has
3/n
The source of ferritin is not exactly known. Hepatocytes, macrophages etc are postulated to be the source.
Ferritin is the major STORAGE IRON form and serves as a surrogate MARKER for total body iron stores.
4/n
Ferritin is the major STORAGE IRON form and serves as a surrogate MARKER for total body iron stores.
4/n
Normal serum values: 30-300 ng/ml
https://abs.twimg.com/emoji/v2/... draggable="false" alt="⬇️" title="Pfeil nach unten" aria-label="Emoji: Pfeil nach unten">
https://abs.twimg.com/emoji/v2/... draggable="false" alt="⬇️" title="Pfeil nach unten" aria-label="Emoji: Pfeil nach unten">ferritin:
1 Iron def anemia
2 Hypothyroidism
3 Ascorbate defeciency
https://abs.twimg.com/emoji/v2/... draggable="false" alt="⬆️" title="Pfeil nach oben" aria-label="Emoji: Pfeil nach oben">
https://abs.twimg.com/emoji/v2/... draggable="false" alt="⬆️" title="Pfeil nach oben" aria-label="Emoji: Pfeil nach oben">Ferritin has many causes:
1 Transfusion iron overload
2 Hereditary Hemsiderosis
3 Inflammation
4 Cancer
5 HLH/MAS cause extreme elevation.
5/n
1 Iron def anemia
2 Hypothyroidism
3 Ascorbate defeciency
1 Transfusion iron overload
2 Hereditary Hemsiderosis
3 Inflammation
4 Cancer
5 HLH/MAS cause extreme elevation.
5/n
Low ferritin is quite specific for iron def anemia but
https://abs.twimg.com/emoji/v2/... draggable="false" alt="⬆️" title="Pfeil nach oben" aria-label="Emoji: Pfeil nach oben">
https://abs.twimg.com/emoji/v2/... draggable="false" alt="⬆️" title="Pfeil nach oben" aria-label="Emoji: Pfeil nach oben">Ferritin ≠ iron overload always. Inflammation etc lead to chronically
https://abs.twimg.com/emoji/v2/... draggable="false" alt="⬆️" title="Pfeil nach oben" aria-label="Emoji: Pfeil nach oben">Ferritin levels.
#COVID19 causes
https://abs.twimg.com/emoji/v2/... draggable="false" alt="⬆️" title="Pfeil nach oben" aria-label="Emoji: Pfeil nach oben">Ferritin because of the inflammatory cytokines.
6/n
#COVID19 causes
6/n
Remember that
https://abs.twimg.com/emoji/v2/... draggable="false" alt="⬆️" title="Pfeil nach oben" aria-label="Emoji: Pfeil nach oben">
https://abs.twimg.com/emoji/v2/... draggable="false" alt="⬆️" title="Pfeil nach oben" aria-label="Emoji: Pfeil nach oben">Ferritin ISN& #39;T THE ONLY CRITERIA FOR HLH. There are 7 more !!
7/7
@HaryaxPathak @pankti4299 @PanktiMehta24 @AlishaAkhani @hard_dil @scalpel_heals @viswas_mr @DevPalkar @shreya__kataria @docsamdeshmukh #COVID19 #CoronaPandemic
7/7
@HaryaxPathak @pankti4299 @PanktiMehta24 @AlishaAkhani @hard_dil @scalpel_heals @viswas_mr @DevPalkar @shreya__kataria @docsamdeshmukh #COVID19 #CoronaPandemic