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#FERRITIN is being widely ordered these days. Let's dive into the details and learn more about this protein. A short thread for those interested. Covers some history, biology and practical aspects about FERRITIN.
1/n
1/n
It was discovered in 1937 by Laufbérger but it wasn't until 1972 that an assay was devised to measure serum ferritin.
Ferritin is present in 2 forms
Intra-cellular (in the cytosol)
Extra-cellular
2/n
Ferritin is present in 2 forms
Intra-cellular (in the cytosol) Extra-cellular2/n
It is a ~450kDa protein.
Has 24 subunits of 2 major types
H : gene on chr 11q
L : gene on chr 19q
Serum ferritin has
L: H ratio.
3/n
Has 24 subunits of 2 major types
H : gene on chr 11q L : gene on chr 19qSerum ferritin has
L: H ratio.3/n
The source of ferritin is not exactly known. Hepatocytes, macrophages etc are postulated to be the source.
Ferritin is the major STORAGE IRON form and serves as a surrogate MARKER for total body iron stores.
4/n
Ferritin is the major STORAGE IRON form and serves as a surrogate MARKER for total body iron stores.
4/n
Normal serum values: 30-300 ng/ml
ferritin:
1 Iron def anemia
2 Hypothyroidism
3 Ascorbate defeciency
Ferritin has many causes:
1 Transfusion iron overload
2 Hereditary Hemsiderosis
3 Inflammation
4 Cancer
5 HLH/MAS cause extreme elevation.
5/n
ferritin:1 Iron def anemia
2 Hypothyroidism
3 Ascorbate defeciency
Ferritin has many causes:1 Transfusion iron overload
2 Hereditary Hemsiderosis
3 Inflammation
4 Cancer
5 HLH/MAS cause extreme elevation.
5/n
Low ferritin is quite specific for iron def anemia butFerritin ≠ iron overload always. Inflammation etc lead to chronically Ferritin levels.
#COVID19 causesFerritin because of the inflammatory cytokines.
6/n
Ferritin ≠ iron overload always. Inflammation etc lead to chronically Ferritin levels.#COVID19 causes
Ferritin because of the inflammatory cytokines.6/n
Remember that Ferritin ISN'T THE ONLY CRITERIA FOR HLH. There are 7 more !!
7/7
@HaryaxPathak @pankti4299 @PanktiMehta24 @AlishaAkhani @hard_dil @scalpel_heals @viswas_mr @DevPalkar @shreya__kataria @docsamdeshmukh #COVID19 #CoronaPandemic
Ferritin ISN'T THE ONLY CRITERIA FOR HLH. There are 7 more !!7/7
@HaryaxPathak @pankti4299 @PanktiMehta24 @AlishaAkhani @hard_dil @scalpel_heals @viswas_mr @DevPalkar @shreya__kataria @docsamdeshmukh #COVID19 #CoronaPandemic
