B.1.617.2 (which is a variant found first in India) has today been declared a Variant of Concern (VOC) due to a high increase in cases in the UK and evidence of higher transmissibility.
(1/n)

there is no evidence that the vaccines are less effective in the case of this variant. So far we have only preliminary data indicating this, but this VOC does not contain any mutations that we know that lower the effectiveness of the neutralizing Ab (2/n)

Apart from that, we need to remember that the 'Indian' variant is not one variant but in fact three: B.1.617.1, B.1.617.2, B.1.617.3. They all are quite similar but contain some different mutations. (3/n)

VOC B.1.617.2 does not have a substitution in its spike protein like the other two: E484Q, which is in the same position as the famous E484K mutation that lowers the efficacy of neutralizing antibodies according to lab data, and which is present in P.1 and B.1.351 variant. (4/n)

E484Q according to the preliminary data I mentioned above does not lower the vaccine efficacy though. (5/n)

But B.1.617.2 instead carries the T478K mutation in the spike protein, a mutation which we haven't previously been exhibited often, and two deletions, one in the spike and one in ORF8. (6/n)

But I'm afraid it is as exciting as it sounds! It is exciting for me because I work with viral evolution and new things look interesting, but you should not be very alarmed about it. So far there is no evidence that this variant can render our vaccines ineffective.(7/n)