I’m really excited to share our review on Translational Hydrogels @ACSPublications @ACSChemRev!! I hope that this will be a useful resource for folks who are either beginning or far along in their biomaterials journey

https://pubs-acs-org.stanford.idm.oclc.org/doi/10.1021/acs.chemrev.0c01177#.YJAuIi-mjM0.twitter

This article is a celebration of the interdisciplinary work that has advanced hydrogel technologies to where we are today, and takes a special interest in the emergence of injectable hydrogels that are creating a renaissance for localized therapies

Injectable hydrogels formed through dynamic interactions are an opportunity to address a variety of medical and non-medical challenges, and so we took care to discuss the unique rheological considerations researchers need to keep in mind while developing these materials

For those coming into this space, we provide a nice primer on strategies for controlled release of small molecules, nucleic acids, and protein cargos.

We then discuss drug delivery in the context of immuno-oncology and immuno engineering, which is expanding the scope and ambition of local drug delivery to whole new levels.

Tissue regeneration has long been and continues to be a major area of research for hydrogel technologies. Here, we focus on the idea of cellular therapies and the development of materials that facilitate cells-as-cargo.

We also branch out into some paths that often less explored, but represent emergent and important applications for hydrogel materials. These include the use of hydrogels as tools for improving surgeries and the development of hydrogel coatings for implantable devices and sensors.

We round out our discussion of biomedical hydrogels with an assessment of the clinical landscape for injectable formulations. We look at the clinical trials underway at the time of writing and consider some of the manufacturing challenges facing commercialization

It’s important to remember that society is facing critical challenges outside of the clinic as well, so we also include a short primer of how lessons learned from biomedical hydrogels can be repurposed towards addressing pressing needs in the environmental space

I want to give a huge shout out to all the incredible folks who helped put this gargantuan review together, it has been a long road and it is just terrific to see this out in the world now. @abigail_kate95 @HectorLopezPhD @doreencchan Lyndsay Stapleton @antcyu @AppelGroup

if that link doesn't work try this one https://pubs.acs.org/doi/10.1021/acs.chemrev.0c01177