Here are my best tips to succeeding in Returnal
#PS5:

The Carbine with Leeching Rounds, especially with Rising Putch mod, is one of the best weapons for bosses. Upgrade Leeching Rounds to Lvl 3 and you’re unstoppable

Always take the Parasite that revives you on death

You need either (1) the Artifact that heals you at low Integrity OR the parasite that heals you. No matter what the debuff always equip the healing parasite

Fabricate the blade enhancer artifact so you can destroy the yellow doors. Always good stuff behind them

Never use your Ethers to cleanse containers, Resins or Obolites. Such as waste of Ethers

Malignant containers and Resins are only ever worth getting unless you’re early in the level. You never want to fight a boss with a Malfunction

Large malignant Obilites are generally worth getting a Malfunction because you absolutely need the obolites to fabricate good stuff

Always horde Ethers because you want to use the fabricator by your ship. Items gradually need more Ethers (10+ Ethers eventually)

Even when you unlock the shortcuts to Biome 2 or 3, when you die it’s still worth your time to redo all of Biome 1 to increase your Integrity, get Obolites, get Artifacts and upgrade your stats.

The Thermogetic Launcher with Full Auto is #1 best weapon in the game

Use the doors between rooms to your advantage. If you go into a full room of powerful enemies back out to the previous room and close the door. Then slowly walk forward, open the door and fire away. Then back up again so the door closes. Safest way to take out a dangerous room.

Some rooms having locking doors. These generally have 5-10 regular enemies + 1 mini boss. The regular enemies attack right away but the boss ONLY appears when the door locks. So stand in the doorway (that way it won’t lock) and kill the regular enemies. THEN go fight the boss

For the daily challenges, while getting the high score for the leaderboard is cool, it’s WAY more important to just survive the challenge so you get the 5 Ethers. Take your time and claim your Ethers

Absolutely fabricate the Astronaut because it gives you a free life

You might find a fabricator to upgrade your Proficiency Rate. While proficiency is good, weapons damage, protection, repair efficiency and max integrity are all way more important. Save your Obolites for those fabricators (unless you have plenty of Obolites to spare)

It’s better to dash INTO enemy fire then away from it. You’re invincible to enemy bullets when dashing. The only exception I believe are the dark purple expanding circles some bosses shoot. Those can’t be dashed through

Shoots statues and plant life as they can have Obolites

Whenever you find a weapon with a locked mod it’s generally best to swap to it, even if you like your current weapon. Once you unlock a mod it’s permanently unlocked for all future runs. Even some of the “bad” weapons like the Sidearm have powerful mods. So unlock ‘em!

You also want to unlock Weapon mods because the mods have 3 levels. Once you unlock a Level 1 mod the next time you find the gun it might have a Level 2 upgrade you can unlock. Upgrade all gun mods to Level 3!
Last tip (for now):

Many room have yellow glowing spots where the floor crumbles and you drop to a bonus room. I suggest having 250 Obolites (or more) before dropping. Some rooms have fabricators with powerful upgrades or Artifacts. Don’t enter a bonus room with no Obolites!
Tip: mention @twtextapp on a Twitter thread with the keyword “unroll” to get a link to it.