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https://archive.is/MMXuF
SARS-CoV-2 the only position 1 undeleted RBM with a non-aromatic 498, which upon substitution with an aromatic residue, increases binding to all ACE2? Why a virus will want to decrease it’s own infectivity and transmissibility just to dodge an ACE2 that it
SARS-CoV-2 the only position 1 undeleted RBM with a non-aromatic 498, which upon substitution with an aromatic residue, increases binding to all ACE2? Why a virus will want to decrease it’s own infectivity and transmissibility just to dodge an ACE2 that it
Supposedly never encountered in any part of it’s supposed history?
Only humans specify an organism to *NOT* do, in detriment to the organism’s own interest of propagating itself fastest and most efficiently. An virus would never evolve in nature specifically to just reduce it’s infectivity and transmissibility. Y498Q is self defeating in any
Kind of proposed reservoir environment, especially since competition exist in all hosts of viruses. Even competition against mutated versions of yourself—a Q498Y or Q498H mutant of SARS-CoV-2 will outgrow Q498 in a highly immunologically fit wildlife host. (Required for survival
In the wild). @CZilcho
