Weasel by Dave Cooper (5 issues) - From the golden age of single-creator anthologies! Plus there's some choice bits from Mike Mignola and Pat McKeown in the back of these.
Nowhere by Debbie Drechsler-The fact that the comics industry did not support more work from Drechsler is a crying shame & as good of an indictment of capitalism as you might need on a Friday afternoon. The writing is perfect & her approach to layering color was v.influential 2me
Epoxy by John Pham - another 1-creator antho. Watching John's style/focus/aesthetic concerns shift and grow over the last 20 years(!) has been quite a ride.
Metropol by Ted McKeever - Really emblematic of a certain stripe of "artsy genre" comics from the early 90s. Proto-Vertigo meets proto-Ft. Thunder. Plus: Mignola back ups!
Hobtown Mystery Stories by Kris Bertin & Alexander Forbes - These "nancy drew by way of twin peaks" comics deliver in a way that things with that kind of high concept sounding logline almost never do. These are funny, wonky, eerie and *very Canadian* tales of teen sleuths.
Ping Pong by Taiyo Matsumoto - one of the GOAT draftsmen, this bromance sports comic will resonate with anyone that was labeled "gifted" in grade school, especially if it fucked with your head.

Kramer's Ergot 4 by various - Best issue? Maybe, maybe not but my copy that I got at MOCCA when it dropped was signed by everyone there & some scumfuck stole it(?) later so I haven't seen it for years. I'm bitter about it!
Felt like an atomic blast of comics potential, in 2003.

Felt like an atomic blast of comics potential, in 2003.
Fun fact: this pic is from an ebay listing for John Porcellino's copy (sold by someone else)

Tongue*Lash by Dave Taylor, Randy/JM Lofficier - These fairly horny comics are like "softcore INCAL noir." Writing & worldbuilding is interesting but the art is really why we're here. I like how they treat sex and kink as very matter of fact bits of character enriching detail.
The Smithsonian Collection of Comic Strip Comics, by various - Edited by literal Comics Saint Bill Blackbeard & Martin Williams, this 1977 book is still probably the go-to survey of the art form. If you buy one book of strip reprints, this is the one. Transformative/mind blowing.
Gus and His Gang, by Christophe Blain - comics about friendship, romance, falling into the same old bad habits, and occasionally some heists.
Highbone Theater by Joe Daly - surreal and hilarious comics about weirdos, autodidacts, masculinity, stoners, conspiracy theories and general dude-ness. Joe Daly is one of the funniest cartoonists around, and his art is like Chester Brown crossed with early Charles Burns.
Grip by Lale Westvind - A sustained, virtuosic exploration of motion, creation, transformation and powerârestlessly inventive. Grip is like a Jademan comic stripped of melodrama.
BPRD by Guy Davis, John Arcudi, Dave Stewart & Mike Mignola - There was a good 5+ years where the best superhero comic on the stands was actually a horror comic drawn by Guy Davis. Major props to Arcudi for his scripting & keeping the always-simmering plotlines moving naturally.
The Adventures of Luther Arkwright by Bryan Talbot - The work of a young man with something to prove. Talbot's art comes across as claustrophobically hyperreal at times. Dense, cryptic, trippy, sexy AND gross, all at onceâArkwright feels overstuffed in the best way.