It was great to be with all of my friends at @ACPinternists today at #ACP2021! I gave the #UpdatesInGI talk, so want to summarize the 7 papers here! These are what YOU, my #GITwitter and #MedTwitter friends, helped identify as the top papers for the last year....
Paper 1:

Not all “GERD” = #GERD. @AGA_CGH

Who may benefit from PPIs most?
➡️Esophagitis
➡️Barrett’s
➡️Heartburn w/ or w/o esophagitis
➡️Regurg w/ or w/o esophagitis
➡️Chest pain w/objective GERD
➡️Cough w/objective GERD

The rest 🤷🏻‍♀️ or 🚫

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6960363/
Paper 1: Not all “GERD” = #GERD. @AGA_CGH Who may benefit from PPIs most?EsophagitisBarrett’sHeartburn w/ or w/o esophagitisRegurg w/ or w/o esophagitisChest pain w/objective GERDCough w/objective GERDThe rest or https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6960363/
Paper 1: Not all “GERD” = #GERD. @AGA_CGH Who may benefit from PPIs most?EsophagitisBarrett’sHeartburn w/ or w/o esophagitisRegurg w/ or w/o esophagitisChest pain w/objective GERDCough w/objective GERDThe rest or https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6960363/
Paper 1: Not all “GERD” = #GERD. @AGA_CGH Who may benefit from PPIs most?EsophagitisBarrett’sHeartburn w/ or w/o esophagitisRegurg w/ or w/o esophagitisChest pain w/objective GERDCough w/objective GERDThe rest or https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6960363/
Paper 1: Not all “GERD” = #GERD. @AGA_CGH Who may benefit from PPIs most?EsophagitisBarrett’sHeartburn w/ or w/o esophagitisRegurg w/ or w/o esophagitisChest pain w/objective GERDCough w/objective GERDThe rest or https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6960363/
Paper 2:

PPIs for persistent throat sxs? 🚫

In R-DB-PCT trial:
👉🏼346 pts w/persistent throat sxs
👉🏼Lansoprazole 30 BID x16 wks vs placebo
👉🏼Outcome: rsp at 16 wks w/reflux sx index (RSI)

FINDING: No statistical difference in RSI b/t the groups.

https://www.bmj.com/content/bmj/372/bmj.m4903.full.pdf
Paper 2: PPIs for persistent throat sxs? In R-DB-PCT trial:346 pts w/persistent throat sxs Lansoprazole 30 BID x16 wks vs placeboOutcome: rsp at 16 wks w/reflux sx index (RSI)FINDING: No statistical difference in RSI b/t the groups. https://www.bmj.com/content/bmj/372/bmj.m4903.full.pdf
Paper 2: PPIs for persistent throat sxs? In R-DB-PCT trial:346 pts w/persistent throat sxs Lansoprazole 30 BID x16 wks vs placeboOutcome: rsp at 16 wks w/reflux sx index (RSI)FINDING: No statistical difference in RSI b/t the groups. https://www.bmj.com/content/bmj/372/bmj.m4903.full.pdf
Paper 2: PPIs for persistent throat sxs? In R-DB-PCT trial:346 pts w/persistent throat sxs Lansoprazole 30 BID x16 wks vs placeboOutcome: rsp at 16 wks w/reflux sx index (RSI)FINDING: No statistical difference in RSI b/t the groups. https://www.bmj.com/content/bmj/372/bmj.m4903.full.pdf
Paper 2: PPIs for persistent throat sxs? In R-DB-PCT trial:346 pts w/persistent throat sxs Lansoprazole 30 BID x16 wks vs placeboOutcome: rsp at 16 wks w/reflux sx index (RSI)FINDING: No statistical difference in RSI b/t the groups. https://www.bmj.com/content/bmj/372/bmj.m4903.full.pdf
Paper 3:

New @AmCollegeGastro #ColorectalCancerScreening Guidelines

A few key points:
🔑CRC screening to start at age 45 for average-risk
🔑Colonoscopy and FIT recommended as primary modalities
🔑Quality metrics of endoscopists part of guidelines!

https://journals.lww.com/ajg/fulltext/2021/03000/acg_clinical_guidelines__colorectal_cancer.14.aspx
Paper 3: New @AmCollegeGastro #ColorectalCancerScreening GuidelinesA few key points:CRC screening to start at age 45 for average-riskColonoscopy and FIT recommended as primary modalitiesQuality metrics of endoscopists part of guidelines! https://journals.lww.com/ajg/fulltext/2021/03000/acg_clinical_guidelines__colorectal_cancer.14.aspx
Paper 3: New @AmCollegeGastro #ColorectalCancerScreening GuidelinesA few key points:CRC screening to start at age 45 for average-riskColonoscopy and FIT recommended as primary modalitiesQuality metrics of endoscopists part of guidelines! https://journals.lww.com/ajg/fulltext/2021/03000/acg_clinical_guidelines__colorectal_cancer.14.aspx
Paper 3: New @AmCollegeGastro #ColorectalCancerScreening GuidelinesA few key points:CRC screening to start at age 45 for average-riskColonoscopy and FIT recommended as primary modalitiesQuality metrics of endoscopists part of guidelines! https://journals.lww.com/ajg/fulltext/2021/03000/acg_clinical_guidelines__colorectal_cancer.14.aspx
Paper 3: New @AmCollegeGastro #ColorectalCancerScreening GuidelinesA few key points:CRC screening to start at age 45 for average-riskColonoscopy and FIT recommended as primary modalitiesQuality metrics of endoscopists part of guidelines! https://journals.lww.com/ajg/fulltext/2021/03000/acg_clinical_guidelines__colorectal_cancer.14.aspx
Paper 4:

Now that colonoscopy done, polyps found, what next? 🤷🏻‍♀️

USMSTF has updated recs for f/u after polypectomy!

Take-home points:
⭐️First ensure high quality colonoscopy (complete, prep ok, skilled endoscopists
⭐️1-2 adenomas < 10 mm = 7-10 yrs!

https://www.gastrojournal.org/action/showPdf?pii=S0016-5085%2819%2941479-0
Paper 4:Now that colonoscopy done, polyps found, what next? USMSTF has updated recs for f/u after polypectomy!Take-home points:First ensure high quality colonoscopy (complete, prep ok, skilled endoscopists1-2 adenomas < 10 mm = 7-10 yrs! https://www.gastrojournal.org/action/showPdf?pii=S0016-5085%2819%2941479-0
Paper 4:Now that colonoscopy done, polyps found, what next? USMSTF has updated recs for f/u after polypectomy!Take-home points:First ensure high quality colonoscopy (complete, prep ok, skilled endoscopists1-2 adenomas < 10 mm = 7-10 yrs! https://www.gastrojournal.org/action/showPdf?pii=S0016-5085%2819%2941479-0
Paper 4:Now that colonoscopy done, polyps found, what next? USMSTF has updated recs for f/u after polypectomy!Take-home points:First ensure high quality colonoscopy (complete, prep ok, skilled endoscopists1-2 adenomas < 10 mm = 7-10 yrs! https://www.gastrojournal.org/action/showPdf?pii=S0016-5085%2819%2941479-0
Paper 4:Now that colonoscopy done, polyps found, what next? USMSTF has updated recs for f/u after polypectomy!Take-home points:First ensure high quality colonoscopy (complete, prep ok, skilled endoscopists1-2 adenomas < 10 mm = 7-10 yrs! https://www.gastrojournal.org/action/showPdf?pii=S0016-5085%2819%2941479-0
Paper 5:

PIANO 🎹 study looking at pregnancy and neonatal outcomes in women with #IBD on #Biologics and #Thiopurines

No increase in:
🤰Congenital malformations
🤰Spontaneous abortions
🤰Preterm birth
🤰Low birth weight
🤰Milestones

https://www.gastrojournal.org/action/showPdf?pii=S0016-5085%2820%2935441-X
Paper 5:PIANO study looking at pregnancy and neonatal outcomes in women with #IBD on #Biologics and #ThiopurinesNo increase in:Congenital malformations Spontaneous abortionsPreterm birthLow birth weightMilestones https://www.gastrojournal.org/action/showPdf?pii=S0016-5085%2820%2935441-X
Paper 5:PIANO study looking at pregnancy and neonatal outcomes in women with #IBD on #Biologics and #ThiopurinesNo increase in:Congenital malformations Spontaneous abortionsPreterm birthLow birth weightMilestones https://www.gastrojournal.org/action/showPdf?pii=S0016-5085%2820%2935441-X
Paper 5:PIANO study looking at pregnancy and neonatal outcomes in women with #IBD on #Biologics and #ThiopurinesNo increase in:Congenital malformations Spontaneous abortionsPreterm birthLow birth weightMilestones https://www.gastrojournal.org/action/showPdf?pii=S0016-5085%2820%2935441-X
Paper 5:PIANO study looking at pregnancy and neonatal outcomes in women with #IBD on #Biologics and #ThiopurinesNo increase in:Congenital malformations Spontaneous abortionsPreterm birthLow birth weightMilestones https://www.gastrojournal.org/action/showPdf?pii=S0016-5085%2820%2935441-X
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