Brazil clarified today that Sputnik V:
1) contains no more than 1 live particle per billion
2) was not actually tested by Brasil but by the manufacturer in regular QC
3) is an E1/E3-deletion vaccine.
Speculation that Sputnik is chock full of live virus is not data-based.

ANVISA made a legitimate decision not to approve because they want better quality: a more intrinsically safe manufacturing process, and 300×-lower cutoff for acceptable live-virus levels. They did not make a new discovery about how Sputnik V works.

In the absence of ANVISA& #39;s clarification, I wrote that the two possibilities were recombination and contamination but not failure to delete E1/E3 (as some incorrectly assumed). ANVISA cites mfg tests that would be more consistent with recombination than contamination.

I am surprised at the credulity of many of my colleagues who FAILED TO EXAMINE THE UNDERLYING TEXTS. Now, we didn& #39;t have the full ANVISA explanation until today, just an unclear report. But there was still a lot to go on that most of covid-twitter just ignored.