1/ COVID-19 has "anisotropic" infection:

Despite 100 times LOWER dose, monkeys infected by SARS-CoV-2 thru aerosols developed MORE SEVERE respiratory disease and lung pathology (vs. nose/trachea)

Preprint from US Army Infectious Diseases Research Inst: https://www.biorxiv.org/content/10.1101/2021.04.27.441510v1">https://www.biorxiv.org/content/1...
2/ This further argues for the importance of aerosols over large droplets, adding an 11th reason to the 10 that we summarized in our recent @TheLancet paper ( https://www.thelancet.com/journals/lancet/article/PIIS0140-6736(21)00869-2/fulltext)

A">https://www.thelancet.com/journals/... step-by-step explanation in this thread: https://twitter.com/jljcolorado/status/1383566908797059078">https://twitter.com/jljcolora...
3/ Note that this has been demonstrated for other diseases such as the flu, for which the intranasal dose needs to be 100000 (one hundred thousand) times larger to lead to the same symptoms, compared to aerosol infection. See:
https://journals.sagepub.com/doi/abs/10.3181/00379727-122-31255">https://journals.sagepub.com/doi/abs/1... https://onlinelibrary.wiley.com/doi/abs/10.1002/jmv.1890030303">https://onlinelibrary.wiley.com/doi/abs/1...
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