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1/ COVID-19 has "anisotropic" infection:
Despite 100 times LOWER dose, monkeys infected by SARS-CoV-2 thru aerosols developed MORE SEVERE respiratory disease and lung pathology (vs. nose/trachea)
Preprint from US Army Infectious Diseases Research Inst: https://www.biorxiv.org/content/10.1101/2021.04.27.441510v1
Despite 100 times LOWER dose, monkeys infected by SARS-CoV-2 thru aerosols developed MORE SEVERE respiratory disease and lung pathology (vs. nose/trachea)
Preprint from US Army Infectious Diseases Research Inst: https://www.biorxiv.org/content/10.1101/2021.04.27.441510v1
2/ This further argues for the importance of aerosols over large droplets, adding an 11th reason to the 10 that we summarized in our recent @TheLancet paper ( https://www.thelancet.com/journals/lancet/article/PIIS0140-6736(21)00869-2/fulltext)
A step-by-step explanation in this thread: https://twitter.com/jljcolorado/status/1383566908797059078
A step-by-step explanation in this thread: https://twitter.com/jljcolorado/status/1383566908797059078
3/ Note that this has been demonstrated for other diseases such as the flu, for which the intranasal dose needs to be 100000 (one hundred thousand) times larger to lead to the same symptoms, compared to aerosol infection. See:
https://journals.sagepub.com/doi/abs/10.3181/00379727-122-31255 https://onlinelibrary.wiley.com/doi/abs/10.1002/jmv.1890030303
https://journals.sagepub.com/doi/abs/10.3181/00379727-122-31255 https://onlinelibrary.wiley.com/doi/abs/10.1002/jmv.1890030303
4/ Smallpox was also an anisotropic infection.
@Don_Milton (in paper below): "Smallpox appears to have been most effectively and virulently transmitted by fine particle aerosols" https://www.frontiersin.org/articles/10.3389/fcimb.2012.00150/full
@Don_Milton (in paper below): "Smallpox appears to have been most effectively and virulently transmitted by fine particle aerosols" https://www.frontiersin.org/articles/10.3389/fcimb.2012.00150/full
5/ HT this article in @redaccionmedica by @clarahroman https://www.redaccionmedica.com/secciones/sanidad-hoy/covid-contagio-aerosoles-enfermedad-grave-6488
