New results from a collaboration with @Masopust_Vezys aiming to determine the potential role of memory T cells in protection against SARS-CoV-2.
https://www.biorxiv.org/content/10.1101/2021.04.26.441518v1
1/3">https://www.biorxiv.org/content/1...
Nucleocapsid vaccine elicits spike-independent SARS-CoV-2 protective immunity

Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is responsible for the COVID-19 pandemic. Neutralizing antibodies target the receptor-binding domain of the spike (S) protein, a focus of...

https://www.biorxiv.org/content/10.1101/2021.04.26.441518v1
Using an adenovirus expressing N we demonstrate protection from disease and reduction in lung virus titers in mice and hamsters (WA and B117). By depleting CD4s and CD8s we demonstrate that reduction in virus load correlates with SARS-specific CD8 T cell numbers in the lungs. 2/3
We argue that memory T cells can provide protection and should be considered in future vaccines designed to provide broad protection, potentially buttressing against Ab escape variants. Work led by @willmatchett, @Vineet_Joag, and Michael Stolley. A huge collaborative effort! 3/3
You can follow @LangloisLab.
Tip: mention @twtextapp on a Twitter thread with the keyword “unroll” to get a link to it.

Latest Threads Unrolled:
There are a lot of misconceptions about the Turkish diaspora in Germany. Since i just finished writing an essay about this topic I thought it's time to give other people
Read more
Las mejores calculadoras online en 2020A thread http://totumat.com/2020/11/26/las-mejores-calculadoras-online-en-2020/ Cuando se estudian asignaturas que requieren de cálculos complicados, nada mejor que contar con una buena calculadora.
Read more
Mitigating #ClimateChange is as much about taking up new techs as about leaving others behindMost studies focus on #coal's global downfall but another #energy tech decline is loomingRead my new
Read more