In addition to our cohort optimised for #PheWAS our Research Tissue Bank also includes a unique set of samples taken from healthy subjects over time

This Longitudinal Study of the Healthy #LSoH cohort allows us to quantify temporal versus inter-subject variability of analytes

This is an essential step for qualifying novel biomarkers and for the optimal design of clinical studies

The greater the temporal variability the more time points are required to give the same power to detect a difference

Our #LSoH cohort features a Fourier series of time points (day 0,1,3,7,14,28,56,114,365 and 720) which allows us to estimate the variability over different timescales

Such data could be the difference between the success & failure of a clinical study - yet is rarely available