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Inspired by recent posts from @AaronGoodman33 , here is my attempt to review briefly the interplay between Hematology and Autoimmune phenomena.
It's magic when that fusion occurs.
Any comments & suggestions appreciated.
#MedTwitter @rabihmgeha @DxRxEdu @CPSolvers
It's magic when that fusion occurs.
Any comments & suggestions appreciated.
#MedTwitter @rabihmgeha @DxRxEdu @CPSolvers
CLL & Autoantibodies:
1.) WAIHA (IgG), CAD (IgM), PCH
2.) PRCA, Autoimmune Neutropenia
3.) C1-NH (acquired angioedema)
4.) GM-CSF (Pulmonary alveolar Proteinosis)
5.) Factor VIII, vWD, V (Coagulopathy)
6.) ADAMTS13 (TTP)
7.) CFH & CFI (aHUS)
contd...
#MedTwitter
1.) WAIHA (IgG), CAD (IgM), PCH
2.) PRCA, Autoimmune Neutropenia
3.) C1-NH (acquired angioedema)
4.) GM-CSF (Pulmonary alveolar Proteinosis)
5.) Factor VIII, vWD, V (Coagulopathy)
6.) ADAMTS13 (TTP)
7.) CFH & CFI (aHUS)
contd...
#MedTwitter
8.) CaSR (Hypocalcemia or Hypercalcemia)
9.) Desmoglein, BPAG1 Envoplakin, Periplakin (Paraneoplastic Pemphigus)
10.) ITP, Evans syndrome
11.) Insulin or Insulin receptor (Hypoglycemia or Hyperglycemia)
12.) C3 Nephritic factor (MPGN1)
#MedTwitter #hematology
9.) Desmoglein, BPAG1 Envoplakin, Periplakin (Paraneoplastic Pemphigus)
10.) ITP, Evans syndrome
11.) Insulin or Insulin receptor (Hypoglycemia or Hyperglycemia)
12.) C3 Nephritic factor (MPGN1)
#MedTwitter #hematology
LGL- Neutropenia, Felty syndrome, Immune complexes, RF, Hypergammaglobulinemia, Autoantibodies
Splenic Marginal Zone lymphoma- AIHA, Coombs (-) hemolytic anemia due to cold IgG, Lupus anticoagulant, IgM anti-cardiolipin, ITP. Sometimes associated with HCV
#hematology
Splenic Marginal Zone lymphoma- AIHA, Coombs (-) hemolytic anemia due to cold IgG, Lupus anticoagulant, IgM anti-cardiolipin, ITP. Sometimes associated with HCV
#hematology
Hairy cell leukemia- Polyarteritis nodosa
Myelodysplastic syndromes/CMML/MDS-MPN overlap- Systemic Vasculitis, Cutaneous Vasculitis
CMML- Arthritis, Pleural effusion, Ascites, Pericardial effusion
Primary myelofibrosis- AIHA, RF, Autoimmune diseases
#hematology #MedTwitter
Myelodysplastic syndromes/CMML/MDS-MPN overlap- Systemic Vasculitis, Cutaneous Vasculitis
CMML- Arthritis, Pleural effusion, Ascites, Pericardial effusion
Primary myelofibrosis- AIHA, RF, Autoimmune diseases
#hematology #MedTwitter
Angioimmunoblastic T-cell lymphoma- RF, Immune complexes, Autoantibodies, Hypergammaglobulinemia, Arthritis, Pleural effusion, Ascites, Rash
Enteropathy associated T-cell lymphoma- Celiac disease
Waldenstorm macroglobulinemia- Anti MAG antibodies and Neuropathy
#MedTwitter
Enteropathy associated T-cell lymphoma- Celiac disease
Waldenstorm macroglobulinemia- Anti MAG antibodies and Neuropathy
#MedTwitter
Gamma heavy chain disease/Franklin disease- RA, AIHA, ITP, SLE, Sjogren's, Myasthenia gravis, Vasculitis
MM/WM- Cryoglobulinemic Vasculitis, Hypocomplementemic urticarial Vasculitis, Eosinophilic fascitis, Schnitzler syndrome, Hypergammaglobulinemic macular Vasculitis
MM/WM- Cryoglobulinemic Vasculitis, Hypocomplementemic urticarial Vasculitis, Eosinophilic fascitis, Schnitzler syndrome, Hypergammaglobulinemic macular Vasculitis
RA & SLE- increased risk for NHL & HL
Sjogren's- Extranodal Marginal zone lymphoma/MALToma, Mixed Cryoglobulinemia
SSc- NHL, MM, CLL
#hematology #rheumatology
Sjogren's- Extranodal Marginal zone lymphoma/MALToma, Mixed Cryoglobulinemia
SSc- NHL, MM, CLL
#hematology #rheumatology
