Inspired by recent posts from @AaronGoodman33 , here is my attempt to review briefly the interplay between Hematology and Autoimmune phenomena.

It's magic when that fusion occurs.

Any comments & suggestions appreciated.

#MedTwitter @rabihmgeha @DxRxEdu @CPSolvers

CLL & Autoantibodies:

1.) WAIHA (IgG), CAD (IgM), PCH

2.) PRCA, Autoimmune Neutropenia

3.) C1-NH (acquired angioedema)

4.) GM-CSF (Pulmonary alveolar Proteinosis)

5.) Factor VIII, vWD, V (Coagulopathy)

6.) ADAMTS13 (TTP)

7.) CFH & CFI (aHUS)

contd...

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8.) CaSR (Hypocalcemia or Hypercalcemia)

9.) Desmoglein, BPAG1 Envoplakin, Periplakin (Paraneoplastic Pemphigus)

10.) ITP, Evans syndrome

11.) Insulin or Insulin receptor (Hypoglycemia or Hyperglycemia)

12.) C3 Nephritic factor (MPGN1)

#MedTwitter #hematology

LGL- Neutropenia, Felty syndrome, Immune complexes, RF, Hypergammaglobulinemia, Autoantibodies

Splenic Marginal Zone lymphoma- AIHA, Coombs (-) hemolytic anemia due to cold IgG, Lupus anticoagulant, IgM anti-cardiolipin, ITP. Sometimes associated with HCV

#hematology

Hairy cell leukemia- Polyarteritis nodosa

Myelodysplastic syndromes/CMML/MDS-MPN overlap- Systemic Vasculitis, Cutaneous Vasculitis

CMML- Arthritis, Pleural effusion, Ascites, Pericardial effusion

Primary myelofibrosis- AIHA, RF, Autoimmune diseases

#hematology #MedTwitter

Angioimmunoblastic T-cell lymphoma- RF, Immune complexes, Autoantibodies, Hypergammaglobulinemia, Arthritis, Pleural effusion, Ascites, Rash

Enteropathy associated T-cell lymphoma- Celiac disease

Waldenstorm macroglobulinemia- Anti MAG antibodies and Neuropathy

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Gamma heavy chain disease/Franklin disease- RA, AIHA, ITP, SLE, Sjogren's, Myasthenia gravis, Vasculitis

MM/WM- Cryoglobulinemic Vasculitis, Hypocomplementemic urticarial Vasculitis, Eosinophilic fascitis, Schnitzler syndrome, Hypergammaglobulinemic macular Vasculitis

RA & SLE- increased risk for NHL & HL

Sjogren's- Extranodal Marginal zone lymphoma/MALToma, Mixed Cryoglobulinemia

SSc- NHL, MM, CLL

#hematology #rheumatology