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of passing the virus to others if you are undetectable on antiretroviral therapy because I marveled CDC (a traditionally conservative public health agency, understandably; they are messaging for nation) would put out such a bold statement even though it was true. For breakthrough
infections after vaccination, I hope I, others have convinced you that these are RARE (0.008%) and even more rare for symptomatic infections. 77 million Americans fully vax against COVID, ~5800 symptomatic & asymptomatic but only 4100 symptomatic so 0.005%
https://www.cdc.gov/vaccines/covid-19/health-departments/breakthrough-cases.html">https://www.cdc.gov/vaccines/...
https://www.cdc.gov/vaccines/covid-19/health-departments/breakthrough-cases.html">https://www.cdc.gov/vaccines/...
See that nursing homes are still performing asymptomatic testing after vax of staff & residents even though symptomatic swabbing would reveal what we need to know but think this recent MMWR paper important https://www.cdc.gov/mmwr/volumes/70/wr/mm7017e1.htm">https://www.cdc.gov/mmwr/volu...
in that 22 breakthroughs (most asymptomatic or mild due to good T cell immunity; older patients may not mount as good T cell immunity in some cases), careful contract tracing done and NO transmissions from these breakthrough within facility adding to our transmission table
But what is so important isn& #39;t it, is if your viral load is low in your nose as you fight a new infection and so can& #39;t transmit as shown in other studies, like CID nursing home study? (3 here)
https://www.nature.com/articles/s41591-021-01316-7
https://www.nature.com/articles/... href=" https://www.medrxiv.org/content/10.1101/2021.02.08.21251329v1">https://www.medrxiv.org/content/1... https://academic.oup.com/cid/advance-article/doi/10.1093/cid/ciab263/6188727">https://academic.oup.com/cid/advan...
https://www.nature.com/articles/s41591-021-01316-7
The 2nd article above shows us viral loads decreased at least 4-fold when swab after vaccination and a large study from UK published this week likely even lower by CT values in millions of PCR tests done on asymptomatic individuals after vaccination https://www.medrxiv.org/content/10.1101/2021.04.22.21255913v1">https://www.medrxiv.org/content/1...
This study shows us how important viral loads are in the nose when assessing risk of transmission (asymptomatic even prior to vax 4-fold less likely to transmit) so the very low viral loads in vax unlikely to transmit https://www.thelancet.com/journals/laninf/article/PIIS1473-3099(20)30985-3/fulltext">https://www.thelancet.com/journals/...
So consider this in your testing strategies at schools, nursing homes, workplaces as you open to test only symptomatic people after vaccination (and yes, send for sequencing per CDC surveillance) https://www.popsci.com/story/health/testing-after-covid-vaccine/">https://www.popsci.com/story/hea...
And consider this when you look at reports of breakthrough infections in the literature- first 1) look if asymptomatic (probably shouldn& #39;t have been tested); 2) mild (T cells doing their job); 3) severe (rare) - failure of immune response rarely to vax https://www.salon.com/2021/04/17/breakthrough-cases-covid-19-explainer/">https://www.salon.com/2021/04/1...
Oh and in terms of breakthrough infections in U.S., rate remains astoundingly low. Out of 87 million fully vaccinated, only 5079 symptomatic breakthroughs (0.005%) & only 0.0003% hospitalizations related to COVID-19 & only 0.00009% deaths related to COVID.
https://www.cdc.gov/vaccines/covid-19/health-departments/breakthrough-cases.html">https://www.cdc.gov/vaccines/...
https://www.cdc.gov/vaccines/covid-19/health-departments/breakthrough-cases.html">https://www.cdc.gov/vaccines/...
