1/ First they said we should stay home and wait for them to get us vaccines, they said no Covid-19 treatment worked despite hundreds of assays arguing so, and assays were not good enough.
2/ Then they got us vaccines, before clinical trials were over, the risk was on us, not on government, not on the pharmaceutical industry. You can’t sue government or pharma if you get severe adverse effects. Ok! https://www.cnbc.com/2020/12/16/covid-vaccine-side-effects-compensation-lawsuit.html">https://www.cnbc.com/2020/12/1...
3/ Vaccines had some surprising adverse effects, autoimmune diseases, some deaths apparently related to them, but still, we were ok with it!
https://www.openvaers.com/covid-data?fbclid=IwAR0KzyAr3rD2yDKuRGkW799AoZcHfloiYXftxKSm1p2lyhNK2edR9Wfzy9M">https://www.openvaers.com/covid-dat...
https://www.thelancet.com/journals/lancet/article/PIIS0140-6736(20)32623-4/fulltext">https://www.thelancet.com/journals/... https://www.nejm.org/doi/full/10.1056/NEJMoa2104840">https://www.nejm.org/doi/full/...
https://www.openvaers.com/covid-data?fbclid=IwAR0KzyAr3rD2yDKuRGkW799AoZcHfloiYXftxKSm1p2lyhNK2edR9Wfzy9M">https://www.openvaers.com/covid-dat...
https://www.thelancet.com/journals/lancet/article/PIIS0140-6736(20)32623-4/fulltext">https://www.thelancet.com/journals/... https://www.nejm.org/doi/full/10.1056/NEJMoa2104840">https://www.nejm.org/doi/full/...
4/ Then they said another vaccine dose would be needed
https://www.cnbc.com/2021/04/15/pfizer-ceo-says-third-covid-vaccine-dose-likely-needed-within-12-months.html
They">https://www.cnbc.com/2021/04/1... said another interval between doses would work https://www.reuters.com/article/health-coronavirus-vaccine-sinovac/sinovac-says-its-covid-19-vaccine-more-effective-with-longer-dosing-interval-idINKBN29N13R">https://www.reuters.com/article/h...
https://www.cnbc.com/2021/04/15/pfizer-ceo-says-third-covid-vaccine-dose-likely-needed-within-12-months.html
They">https://www.cnbc.com/2021/04/1... said another interval between doses would work https://www.reuters.com/article/health-coronavirus-vaccine-sinovac/sinovac-says-its-covid-19-vaccine-more-effective-with-longer-dosing-interval-idINKBN29N13R">https://www.reuters.com/article/h...
5/ They said we’ve gotta match the right vaccine with the right virus variant and quickly produce new RNA vaccines to new variants
https://www.forbes.com/sites/siladityaray/2021/04/20/double-mutant-covid-variant-heres-what-we-know-as-israel-reports-vaccine-efficacy-against-variant-first-detected-in-india/?sh=2a4b23342fb3">https://www.forbes.com/sites/sil...
https://www.reuters.com/business/healthcare-pharmaceuticals/astrazeneca-could-have-covid-19-vaccine-against-variant-by-end-2021-austrian-2021-04-18/
https://www.reuters.com/business/... href=" https://news.yahoo.com/astrazeneca-could-covid-19-vaccine-114710686.html">https://news.yahoo.com/astrazene...
We are pushing water uphill with a rake.
https://www.forbes.com/sites/siladityaray/2021/04/20/double-mutant-covid-variant-heres-what-we-know-as-israel-reports-vaccine-efficacy-against-variant-first-detected-in-india/?sh=2a4b23342fb3">https://www.forbes.com/sites/sil...
https://www.reuters.com/business/healthcare-pharmaceuticals/astrazeneca-could-have-covid-19-vaccine-against-variant-by-end-2021-austrian-2021-04-18/
https://www.reuters.com/business/... href=" https://news.yahoo.com/astrazeneca-could-covid-19-vaccine-114710686.html">https://news.yahoo.com/astrazene...
We are pushing water uphill with a rake.
6/ We are going to get new vaccines to new variants and new protocols coming out of our hats, no need for clinical trials, while new variants arise?
Don’t get me wrong!
Don’t get me wrong!
7/ Vaccines are the best plan ever to avoid new surges, even if we need a new one every year (I would just expect more than an neutralizing antibody test to demonstrate the need); a great plan to somewhat protect those much susceptible. Not a solution to this pandemic.
8/ We’ve got to face disease with the repurposed drugs we have, even to treat vaccinated people when they catch symptomatic disease.
9/ But they say we’ve got to raise the bar like we didn’t with evidences we used so far in other diseases, we should allow just perfect assays to guide treatment.
https://jamanetwork.com/journals/jamainternalmedicine/fullarticle/226373?fbclid=IwAR3CX8Bl2M6yQojZEod0dBP2V85GnIfj92sOeyGF0uwl1p1cVL5rZzm89O8
https://jamanetwork.com/journals/... href=" https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6439920/?fbclid=IwAR1boDQzDEMbyhRu6EerXKyj3AWMq_3SYxKgkMBKRRMn82n1KMh4ikNT-Es">https://www.ncbi.nlm.nih.gov/pmc/artic...
https://jamanetwork.com/journals/jamainternalmedicine/fullarticle/226373?fbclid=IwAR3CX8Bl2M6yQojZEod0dBP2V85GnIfj92sOeyGF0uwl1p1cVL5rZzm89O8
https://jamanetwork.com/journals/... href=" https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6439920/?fbclid=IwAR1boDQzDEMbyhRu6EerXKyj3AWMq_3SYxKgkMBKRRMn82n1KMh4ikNT-Es">https://www.ncbi.nlm.nih.gov/pmc/artic...
10/ Coronavac got authorized with the worst set of data one could present to a regulatory agency. Budesonide was almost neglected, colchicine is neglected. Ivermectin is ignored.
Are we searching for Evidence-Based Medicine or Evidences Based in Medicine?
Are we searching for Evidence-Based Medicine or Evidences Based in Medicine?
11/ Are we going to pursue the perfect clinical trial or are we going to use the best evidence available to treat patients?