Thread by @cnpaiva, 1/ First they said we should stay home and wait for them [...]

1/ First they said we should stay home and wait for them to get us vaccines, they said no Covid-19 treatment worked despite hundreds of assays arguing so, and assays were not good enough.

2/ Then they got us vaccines, before clinical trials were over, the risk was on us, not on government, not on the pharmaceutical industry. You can’t sue government or pharma if you get severe adverse effects. Ok! https://www.cnbc.com/2020/12/16/covid-vaccine-side-effects-compensation-lawsuit.html

You can’t sue Pfizer or Moderna if you have severe Covid vaccine side effects. The government...

Companies like Pfizer and Moderna have total immunity from legal liability under the PREP Act if something unintentionally goes wrong with their Covid vaccines.

https://www.cnbc.com/2020/12/16/covid-vaccine-side-effects-compensation-lawsuit.html

3/ Vaccines had some surprising adverse effects, autoimmune diseases, some deaths apparently related to them, but still, we were ok with it!
https://www.openvaers.com/covid-data?fbclid=IwAR0KzyAr3rD2yDKuRGkW799AoZcHfloiYXftxKSm1p2lyhNK2edR9Wfzy9M
https://www.thelancet.com/journals/lancet/article/PIIS0140-6736(20)32623-4/fulltext https://www.nejm.org/doi/full/10.1056/NEJMoa2104840

Thrombotic Thrombocytopenia after ChAdOx1 nCov-19 Vaccination | NEJM

Original Article from The New England Journal of Medicine — Thrombotic Thrombocytopenia after ChAdOx1 nCov-19 Vaccination

https://www.openvaers.com/covid-data?fbclid=IwAR0KzyAr3rD2yDKuRGkW799AoZcHfloiYXftxKSm1p2lyhNK2edR9Wfzy9M

4/ Then they said another vaccine dose would be needed
https://www.cnbc.com/2021/04/15/pfizer-ceo-says-third-covid-vaccine-dose-likely-needed-within-12-months.html

They said another interval between doses would work https://www.reuters.com/article/health-coronavirus-vaccine-sinovac/sinovac-says-its-covid-19-vaccine-more-effective-with-longer-dosing-interval-idINKBN29N13R

Sinovac says its COVID-19 vaccine more effective with longer dosing interval

China's Sinovac Biotech said on Monday that a clinical trial in Brazil showed its COVID-19 vaccine was almost 20 percentage points more effective in a small sub-group of patients who received their...

https://www.cnbc.com/2021/04/15/pfizer-ceo-says-third-covid-vaccine-dose-likely-needed-within-12-months.html

5/ They said we’ve gotta match the right vaccine with the right virus variant and quickly produce new RNA vaccines to new variants
https://www.forbes.com/sites/siladityaray/2021/04/20/double-mutant-covid-variant-heres-what-we-know-as-israel-reports-vaccine-efficacy-against-variant-first-detected-in-india/?sh=2a4b23342fb3
https://www.reuters.com/business/healthcare-pharmaceuticals/astrazeneca-could-have-covid-19-vaccine-against-variant-by-end-2021-austrian-2021-04-18/
https://news.yahoo.com/astrazeneca-could-covid-19-vaccine-114710686.html

We are pushing water uphill with a rake.

AstraZeneca could have COVID-19 vaccine against variant by end-2021: Austrian newspaper

A modified version of AstraZeneca's COVID-19 vaccine tailored to combat a coronavirus variant first documented in South Africa could be ready by the end of 2021, an AstraZeneca official in Austria...

https://www.forbes.com/sites/siladityaray/2021/04/20/double-mutant-covid-variant-heres-what-we-know-as-israel-reports-vaccine-efficacy-against-variant-first-detected-in-india/?sh=2a4b23342fb3

6/ We are going to get new vaccines to new variants and new protocols coming out of our hats, no need for clinical trials, while new variants arise?

Don’t get me wrong!

7/ Vaccines are the best plan ever to avoid new surges, even if we need a new one every year (I would just expect more than an neutralizing antibody test to demonstrate the need); a great plan to somewhat protect those much susceptible. Not a solution to this pandemic.

8/ We’ve got to face disease with the repurposed drugs we have, even to treat vaccinated people when they catch symptomatic disease.

9/ But they say we’ve got to raise the bar like we didn’t with evidences we used so far in other diseases, we should allow just perfect assays to guide treatment.
https://jamanetwork.com/journals/jamainternalmedicine/fullarticle/226373?fbclid=IwAR3CX8Bl2M6yQojZEod0dBP2V85GnIfj92sOeyGF0uwl1p1cVL5rZzm89O8
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6439920/?fbclid=IwAR1boDQzDEMbyhRu6EerXKyj3AWMq_3SYxKgkMBKRRMn82n1KMh4ikNT-Es

Analysis of Overall Level of Evidence Behind Infectious Diseases Society of America Practice...

Background Clinical practice guidelines are developed to assist in patient care. Physicians may assume that following such guidelines means practicing evidence-based medicine. However, the quality...

https://jamanetwork.com/journals/jamainternalmedicine/fullarticle/226373?fbclid=IwAR3CX8Bl2M6yQojZEod0dBP2V85GnIfj92sOeyGF0uwl1p1cVL5rZzm89O8

10/ Coronavac got authorized with the worst set of data one could present to a regulatory agency. Budesonide was almost neglected, colchicine is neglected. Ivermectin is ignored.

Are we searching for Evidence-Based Medicine or Evidences Based in Medicine?

11/ Are we going to pursue the perfect clinical trial or are we going to use the best evidence available to treat patients?

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