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Complex approach to reduce need of oxygen in COVID patients. Aspirin/Nebulized HCQ/glutathion/cyproheptadine. Share to people in charge in hospitals. #doctors #COVID19India #OxygenShortage #Oxygen #COVID19 @COVID19_INDIA @PMOIndia @COVIDNewsByMIB @bkchospital @DrRahulGhule11
To try all together aspirin 300mg (if not taken already), 150mg HCQ (2 ampules-each ampule 3ml of HCQ (25mg/ml)(6ml in total)) via nebulizer daily, 2g of glutathione daily, cyproheptadine (4mg pill/3x a day). #doctors #COVID19India #OxygenShortage #Oxygen #COVID19
1.Aspirin reduce platelets activation
2.Nebulized HCQ - immediate improvement of breathing - HCQ - anti- inflammatory/chemo- protective/anti-autoimmune/lowering antiphospholipid antibody titers and preventing thrombotic recurrences https://docs.google.com/document/d/1WjfphkNfYDxF4MMw7bS9HJpmeGuhwEFuJkUTexjHHOc/edit
https://docs.google.com/document/... href="https://twtext.com//hashtag/doctors"> #doctors #COVID19India
2.Nebulized HCQ - immediate improvement of breathing - HCQ - anti- inflammatory/chemo- protective/anti-autoimmune/lowering antiphospholipid antibody titers and preventing thrombotic recurrences https://docs.google.com/document/d/1WjfphkNfYDxF4MMw7bS9HJpmeGuhwEFuJkUTexjHHOc/edit
#doctors #COVID19India" title="1.Aspirin reduce platelets activation2.Nebulized HCQ - immediate improvement of breathing - HCQ - anti- inflammatory/chemo- protective/anti-autoimmune/lowering antiphospholipid antibody titers and preventing thrombotic recurrences https://docs.google.com/document/... href="https://twtext.com//hashtag/doctors"> #doctors #COVID19India" class="img-responsive" style="max-width:100%;"/>
3.2 g of glutathione - improved dyspnea within 1 h of use – antioxidant/suppress the elevation of blood lactate and as such protects lungs
https://www.immunology.ox.ac.uk/covid-19/covid-19-immunology-literature-reviews/efficacy-of-glutathione-therapy-in-relieving-dyspnea-associated-with-covid-19-pneumonia-a-report-of-2-cases">https://www.immunology.ox.ac.uk/covid-19/... #doctors #COVID19India #OxygenShortage #Oxygen #COVID19
https://www.immunology.ox.ac.uk/covid-19/covid-19-immunology-literature-reviews/efficacy-of-glutathione-therapy-in-relieving-dyspnea-associated-with-covid-19-pneumonia-a-report-of-2-cases">https://www.immunology.ox.ac.uk/covid-19/... #doctors #COVID19India #OxygenShortage #Oxygen #COVID19
4.Cyproheptadine - 4 hours after the cyproheptadine & 10 minutes after the Nicardipine, all echo signs of pulmonary hypertension (PH) were completely gone. https://twitter.com/khaycock2/status/1371299524434489344">https://twitter.com/khaycock2... #doctors #COVID19India #OxygenShortage #Oxygen #COVID19
4.Cyproheptadine - inhibits 5HT signal/ reduce arterial hypoxia by reducing intrapulmonary shunt/ blocks plasma serotonin from triggering more platelet activation, vasoconstriction, and fibrosis
https://papers.ssrn.com/sol3/papers.cfm?abstract_id=3800402
https://papers.ssrn.com/sol3/pape... href="https://twtext.com//hashtag/doctors"> #doctors #COVID19India #OxygenShortage #Oxygen #COVID19
https://papers.ssrn.com/sol3/papers.cfm?abstract_id=3800402
Previously @__ice9 mentioned ITPP which increase tissue oxygenation, but no trials so far for COVID. It could be also considered if its supply is sufficient. #doctors #COVID19India #OxygenShortage #Oxygen #COVID19
https://en.wikipedia.org/wiki/Myo-inositol_trispyrophosphate">https://en.wikipedia.org/wiki/Myo-... https://twitter.com/__ice9/status/1366111770927132676">https://twitter.com/__ice9/st...
https://en.wikipedia.org/wiki/Myo-inositol_trispyrophosphate">https://en.wikipedia.org/wiki/Myo-... https://twitter.com/__ice9/status/1366111770927132676">https://twitter.com/__ice9/st...
https://twitter.com/a_m_molenda/status/1386379116409237509">https://twitter.com/a_m_molen...
Also on https://www.linkedin.com/pulse/complex-approach-reduce-need-oxygen-covid-patients-molenda/">https://www.linkedin.com/pulse/com...
If glutathione is not available but there is access to NAC (N-acetylcysteine), I assume that the effect is the same but delayed. NAC has been described to reduced CRP/ferritin in COVID patients. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7374140/
Inhaled">https://www.ncbi.nlm.nih.gov/pmc/artic... NAC may be too weak for immediate effect.
Inhaled">https://www.ncbi.nlm.nih.gov/pmc/artic... NAC may be too weak for immediate effect.
https://twitter.com/covidology/status/1384338523797393412">https://twitter.com/covidolog...
Significant negative correlation was reported between thiamine (vitamin B1) and lactic acid levels. The administration of thiamine (200 mg twice a day) reduced lactate levels. https://journals.sagepub.com/doi/full/10.1177/0885066620973585">https://journals.sagepub.com/doi/full/...
