Read on Twitter
Excited to share that our most recent paper has been published in the Archives of Toxicology and is now live! In this study, we developed and successfully validated an 81-gene toxicogenomic signature that can be used to identify epigenotoxicants https://rdcu.be/chLIL
We focused on histone deacetylase inhibition (HDACi) as the epigenetic modification. We identified the transcriptomic fingerprint for 10 HDACi reference compounds and created the 81-gene toxicogenomic (TGx) signature, naming it TGx-HDACi
The chemical classification performance of the biomarker was tested using 11 validation compounds, including other histone modulators - so far, TGx-HDACi has demonstrated an accurate classification and specificity toward HDACi!
The overarching goal is to diversify the transcriptomic biomarkers that are available for use in predicting the mode of action of previously untested chemicals and potential adverse effects from gene expression data.
It's been a really unique experience being involved in the whole process of developing and testing a transcriptomic biomarker! Thank you so much to everyone who has contributed to this work, and I can’t wait for our future collaboration!
