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Vitamin E acetate as linactant in the pathophysiology of EVALI - Medical Hypothesis
8/11/2020
#Vaping #associated #lung #injury #pathology #VEA https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7422838/#!po=0.724638
8/11/2020
#Vaping #associated #lung #injury #pathology #VEA https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7422838/#!po=0.724638
“Other than the observation of type II alveolar pneumocyte hyperplasia [8], vacuolization [9], multinucleation [10], and intraalveolar lipid-laden macrophages [11], we still do not have a comprehensive understanding on what the injury exactly is.”
#EVALI #pathophysiology
![“Other than the observation of type II alveolar pneumocyte hyperplasia [8], vacuolization [9], multinucleation [10], and intraalveolar lipid-laden macrophages [11], we still do not have a comprehensive understanding on what the injury exactly is.” #EVALI #pathophysiology](https://pbs.twimg.com/media/Eyn_hXhXMAIT3Wl.jpg "“Other than the observation of type II alveolar pneumocyte hyperplasia [8], vacuolization [9], multinucleation [10], and intraalveolar lipid-laden macrophages [11], we still do not have a comprehensive understanding on what the injury exactly is.” #EVALI #pathophysiology")
#EVALI #pathophysiology
“diagnosis of exclusion”
“..thanks to global efforts to strengthen regulations against e-cigarettes, it is likely that we might not be able to fully characterize the disease before the epidemic is finally over..”
“healthy e-cigarette users without EVALI.” *No THC control
“..thanks to global efforts to strengthen regulations against e-cigarettes, it is likely that we might not be able to fully characterize the disease before the epidemic is finally over..”
“healthy e-cigarette users without EVALI.” *No THC control
#EVALI
I)..gel-liquid crystalline phase transition
ii)..deposition lipid droplet of macrophages
iii)..diacylglycerol kinase & protein kinase C signaling pathway w/ an antidiabetic regulatory role
iv)..xenobiotic-sensing pregnane X receptor signaling
v)..lateral phase separation
I)..gel-liquid crystalline phase transition
ii)..deposition lipid droplet of macrophages
iii)..diacylglycerol kinase & protein kinase C signaling pathway w/ an antidiabetic regulatory role
iv)..xenobiotic-sensing pregnane X receptor signaling
v)..lateral phase separation
“...line-active property of the vitamin deserves academic attention. Although toxic byproducts of heating Vitamin E acetate have recently garnered...interest...there is yet lacking amount of evidence that pinpoints toxic byproducts as the pathological driving force for #EVALI.”
Many thanks to 
