Today is day +1 of my vaccine. What is the vax doing? What are my immune cells doing? (Thread)...

The recombinant adenovirus has entered into many cells whose only job is to express S proteins of SARS2, like muscle cells. But crucially it has also infected APCs, or antigen presenting cells...

The APCs are processing SARS-CoV-2 S antigen into peptides, that it now presents to T cells via Class I HLA. S is starting to tweak T cell receptors that recognize it...

An innate immune response involving type I, then gamma interferon is underway, prompted by invader "adenovirus"...

That response has many roles, but one is to jazz up the "adaptive" immune response to come.
Stay tuned.