"Obesity is caused by an abnormal excess storage of energy as lipids in adipose tissue due to a net imbalance between energy intake and energy expenditure"

Replace obesity w/ any condition/disease, and it& #39;s the same thing: manifested by thermodynamic (energy transfer) misbalance https://twitter.com/NiacinIsHealth/status/1379983233706770434">https://twitter.com/NiacinIsH...
In terms of dementia prevention, this circuit is governed mechanistically by limiting the progression of accumulating thermodynamic net energy forward as we become increasingly more sedentary and immobile after age 70.
In terms of dementia prevention, this circuit is governed mechanistically by limiting the progression of accumulating thermodynamic net energy forward as we become increasingly more sedentary and immobile after age 70.
In terms of dementia prevention, this circuit is governed mechanistically by limiting the progression of accumulating thermodynamic net energy forward as we become increasingly more sedentary and immobile after age 70.
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7093185/figure/f1/?report=objectonly">https://www.ncbi.nlm.nih.gov/pmc/artic... https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7093185/">https://www.ncbi.nlm.nih.gov/pmc/artic...
Leisure-time physical activity volume, intensity, and duration from mid- to late-life in U.S....

Mitigating age-related disease and disability presents challenges. Physical activity (PA) may be influential for prolonging health and functioning, warranting characterization of its patterns over...

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7093185/figure/f1/?report=objectonly
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7093185/figure/f1/?report=objectonly">https://www.ncbi.nlm.nih.gov/pmc/artic...
Leisure-time physical activity volume, intensity, and duration from mid- to late-life in U.S....

Mitigating age-related disease and disability presents challenges. Physical activity (PA) may be influential for prolonging health and functioning, warranting characterization of its patterns over...

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7093185/figure/f1/?report=objectonly
https://osf.io/uec3r/ ">https://osf.io/uec3r/&qu...
https://www.cell.com/cell-metabolism/pdf/S1550-4131(19)30248-7.pdf">https://www.cell.com/cell-meta...
https://twitter.com/NiacinIsHealth/status/1353083862713311232?s=20">https://twitter.com/NiacinIsH...
https://twitter.com/NiacinIsHealth/status/1353072115331735552?s=20">https://twitter.com/NiacinIsH...
https://twitter.com/NiacinIsHealth/status/1378795318137999366">https://twitter.com/NiacinIsH...
"We have identified niacin as a novel clinically approved medication that enhances macrophage/microglia phagocytosis of inhibitory debris, resulting in increased OPC recruitment and ultimately remyelination in the aging CNS." https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7181452/">https://www.ncbi.nlm.nih.gov/pmc/artic...
Niacin-mediated rejuvenation of macrophage/microglia enhances remyelination of the aging central...

Remyelination following CNS demyelination restores rapid signal propagation and protects axons; however, its efficiency declines with increasing age. Both intrinsic changes in the oligodendrocyte...

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7181452/
Told ya https://twitter.com/NiacinIsHealth/status/1378014661640093698?s=20">https://twitter.com/NiacinIsH...
^ https://twitter.com/NiacinIsHealth/status/1353109461704060929?s=20">https://twitter.com/NiacinIsH...
Cancer and Dementia share very determinants/pathological mechanisms, just presenting at different epochs in life https://stm.sciencemag.org/content/12/537/eaay9924">https://stm.sciencemag.org/content/1...
Control of brain tumor growth by reactivating myeloid cells with niacin

Although innate immune cells are typically present inside tumors, they often have an inactive phenotype such that they are ineffective at killing the cancer cells or even promote tumor growth. Sarkar...

https://stm.sciencemag.org/content/12/537/eaay9924
See through here for more... https://twitter.com/niacinishealth/status/1380816788410277891">https://twitter.com/niacinish...
And as for application in #COVID19 https://twitter.com/NiacinIsHealth/status/1380857689895493632">https://twitter.com/NiacinIsH...
Network Pharmacology and bioinformatics analyses identify intersection genes of niacin and COVID-19 as potential therapeutic targets https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7717147/">https://www.ncbi.nlm.nih.gov/pmc/artic...
Network Pharmacology and bioinformatics analyses identify intersection genes of niacin and COVID-19...

Patients with colorectal cancer (CRC) may be susceptible to the coronavirus disease-2019 (COVID-19). However, anti-CRC/COVID-19 treatment options are currently unavailable. Since niacin is a vitamin...

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7717147/
Bye bye #SARS_CoV_2 https://twitter.com/niacinishealth/status/1377377736788860932">https://twitter.com/niacinish...
Niacin, which we remain profoundly deficient upon from daily diet, in ample supply is intrinsic to dynamically preserve fine-tuning of energy homeostasis over life and to prevent + revert unleashing of bioenergetic misbalances that can cascade into autoimmune presentations as so: https://twitter.com/niacinishealth/status/1379852918959050752">https://twitter.com/niacinish...
"Obesity is caused by an abnormal excess storage of energy as lipids in adipose tissue due to a net imbalance between energy intake and energy expenditure"
https://faseb.onlinelibrary.wiley.com/doi/full/10.1096/fj.201801951R">https://faseb.onlinelibrary.wiley.com/doi/full/... https://twitter.com/niacinishealth/status/1380836724096524293">https://twitter.com/niacinish...
One way you can conceptualize how maintaining sufficiently supplied NIACIN (by supplementing beyond diet) intrinsically protects & combats against #SARSCoV2 infection into #COVID19 progression is through stabilization of energy flow as expressed in lipids (to high HDL/low LDL) https://twitter.com/niacinishealth/status/1380720593507598339">https://twitter.com/niacinish...
Upon adjustment for HDL-C, BMI is shown to play no independent role in #COVID whereas controlling for BMI does not affect the association of HDL-C with #COVID19, which points directly to HDL-C as driving the pathogenesis forward.

.......

#epitwitter #MedTwitter https://twitter.com/niacinishealth/status/1380720590429024257">https://twitter.com/niacinish...
This points to lipid stabilization providing a dynamic marker of how balanced energy flow is through the body to counter against inflammation progression into vascular disease, metabolic syndromes, viral-induced #COVID19, neurodegeneration, morbidity in MS
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6794658/">https://www.ncbi.nlm.nih.gov/pmc/artic...
^

https://www.nature.com/articles/s41598-018-35232-7">https://www.nature.com/articles/...
^ http://www.buffalo.edu/news/releases/2015/09/052.html">https://www.buffalo.edu/news/rele...
In MS patients, HDL cholesterol has a protective effect

An international research team led by University at Buffalo scientists has found that HDL cholesterol protects the blood-brain barrier from injury in patients with MS.

http://www.buffalo.edu/news/releases/2015/09/052.html
^

The Triglyceride to High-density Lipoprotein Cholesterol Ratio, an Estimate of Insulin Resistance, is Associated with Incident Coronary Heart Disease https://www.ahajournals.org/doi/abs/10.1161/circ.133.suppl_1.mp37">https://www.ahajournals.org/doi/abs/1...
Abstract MP37: The Triglyceride to High-density Lipoprotein Cholesterol Ratio, an Estimate of...

Introduction: Insulin resistance (IR), a metabolic dysregulation predictive of various clinical sequelae, is reportedly associated with the risk of coronary heart disease (CHD). The invasive nature o

https://www.ahajournals.org/doi/abs/10.1161/circ.133.suppl_1.mp37
Of course cancer too, every disease.... https://www.dovepress.com/increased-blood-lipid-level-is-associated-with-cancer-specific-mortali-peer-reviewed-fulltext-article-RMHP">https://www.dovepress.com/increased...
[Full text] Increased Blood Lipid Level is Associated with Cancer-Specific Mortali | RMHP

Increased Blood Lipid Level is Associated with Cancer-Specific Mortality and All-Cause Mortality in Patients with Colorectal Cancer (≥65 Years): A Population-Based Prospective Cohort Study

https://www.dovepress.com/increased-blood-lipid-level-is-associated-with-cancer-specific-mortali-peer-reviewed-fulltext-article-RMHP
^ https://www.sciencedirect.com/science/article/pii/S1010660X16000276">https://www.sciencedirect.com/science/a...
Hypertension, serum lipids and cancer risk: A review of epidemiological evidence

Although the association between blood pressure, serum lipids and cancer risk has been investigated, the results are controversial. The aim of this li…

https://www.sciencedirect.com/science/article/pii/S1010660X16000276
https://journals.sagepub.com/doi/abs/10.1177/1534735407313883">https://journals.sagepub.com/doi/abs/1...
Significance of Alterations in Plasma Lipid Profile Levels in Breast Cancer - Franky Dhaval Shah,...

Hypotheses. The relationship between lipids and breast cancer is obscure. Until now, conflicting results have been reported on the association between lipids an...

https://journals.sagepub.com/doi/abs/10.1177/1534735407313883
You can follow @NiacinIsHealth.
Tip: mention @twtextapp on a Twitter thread with the keyword “unroll” to get a link to it.

Latest Threads Unrolled:
There are a lot of misconceptions about the Turkish diaspora in Germany. Since i just finished writing an essay about this topic I thought it's time to give other people
Read more
Las mejores calculadoras online en 2020A thread http://totumat.com/2020/11/26/las-mejores-calculadoras-online-en-2020/ Cuando se estudian asignaturas que requieren de cálculos complicados, nada mejor que contar con una buena calculadora.
Read more
Mitigating #ClimateChange is as much about taking up new techs as about leaving others behindMost studies focus on #coal's global downfall but another #energy tech decline is loomingRead my new
Read more