'Today, the most pressing issue to have arisen is whether a global vaccination programme is needed to end the coronavirus crisis. This question is so important that a debate urgently needs to be conducted to reach a global consensus on three basic points.'
'1. When is the development of a vaccine called for? We venture to answer: when an infection regularly leads to severe illness and/or serious sequelae in healthy individuals. This is not the case with SARS-CoV-2.'
'2. When would mass vaccination not be reasonable? We propose that mass vaccination is not reasonable if a large part of the population is already sufficiently protected against a life-threatening disease. This is the case for SARS-CoV-2.'
'3. When is vaccination likely to be unsuccessful? We predict that vaccination will fail when a virus co-existing worldwide with man and animals continuously undergoes mutational change, and when individuals become exposed to high doses during the spread of the infection.'
'In the authors' view, a global vaccination programme therefore makes no sense. Right from the start, the risks far outweigh any possible benefits. Experts around the world have expressed their concerns and warned of rushed COVID-19 vaccines without sufficient safety guarantees.'
'Yet researchers are currently working on more than 150 COVID-19 vaccines. The aim of most vaccines is to achieve high levels of neutralising antibodies against the binding spike proteins of the virus and cellular responses. Four major strategies are being followed.'
'1. Inactivated virus vaccines require production of large quantities of the virus. There is always the risk that a batch will contain contaminants and produce severe side-effects. Moreover, the possibility exists that vaccination may worsen the course of subsequent infection.'
'2. Protein vaccines will contain the virus spike protein or fragments thereof. It is always necessary to supplement these with immune stimulators, adjuvants that may cause serious side-effects.'
'3. Viral vectors as gene-based vaccines integrate the coronavirus gene into a carrier virus that infects our cells. To bolster effectiveness, attempts have been made to create replication-competent vaccines, causing severe side-effects in at least 20% of the vaccinated.'
'4. Gene-based vaccines, in which the viral gene is delivered to the cell either as DNA inserted into a plasmid or as mRNA that is directly translated into protein following cell uptake.'
'A great potential danger of DNA-based vaccines is the integration of plasmid DNA into the cell genome. Insertional mutagenesis occurs rarely, but can become a realistic danger when the number of events is very large, i.e. as in the mass vaccination of a population.'
'If insertion occurs in cells of the reproductive system, the altered genetic information will be transformed from mother to child. Other dangers of DNA vaccines are production of anti-DNA antibodies and autoimmune reactions.'
'Safety concerns linked to mRNA vaccines include systemic inflammation and potential toxic effects. But a further immense danger looms that applies equally to mRNA-based coronavirus vaccines.'
'At some time during or after the production of the viral spike, waste products of the protein must be expected to become exposed on the surface of targeted cells. The majority of healthy individuals have killer lymphocytes that recognise these viral products.'
'Yet hundreds of volunteers who were never informed of these unavoidable risks have already received injections of DNA and mRNA vaccines encoding the spike protein of the virus, and many more are soon to follow.'
'No gene-based vaccine has even received approval for human use, and the present coronavirus vaccines have not undergone preclinical testing as normally required by international regulations.'
'Laws and safety regulations have been bypassed in a manner that would, under normal circumstances, never be possible. Can we go so far as to permit genetic experiments to be conducted on humans who have not been informed of the dangers?'
— Dr. Sucharit Bhakdi, Professor Emeritus of Medical Microbiology, Johannes Gutenberg University, Mainz, and one of the most referenced scientists in German history; and Dr. Karina Reiß, Professor for Epithelial Protease Inhibitors, Department of Dermatology, University of Kiel.
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