Thread by @Angelaisawake, Thread:Johnson & Johnson gene therapy used adenovirus as a viral vector. “Several [...]

Thread:

Johnson & Johnson gene therapy used adenovirus as a viral vector. “Several studies have shown major drawbacks to using adenovirus as a vaccine & as gene therapy vectors”
https://www.intechopen.com/books/adenoviruses/adenoviral-vector-based-vaccines-and-gene-therapies-current-status-and-future-prospects
Viruses are used as vectors to deliver the new gene by infecting the cell.

“The adenoviruses are named after the human adenoids, from which they were first isolated. Several adenoviruses can cause respiratory and conjunctival diseases.” https://www.ncbi.nlm.nih.gov/books/NBK8503/

Adenoviruses

The adenoviruses are common pathogens of humans and animals. Moreover, several strains have been the subject of intensive research and are used as tools in mammalian molecular biology. More than 100...

https://www.ncbi.nlm.nih.gov/books/NBK8503/

“Despite their improved safety, high-capacity adenoviral vectors can still trigger transient toxic effects in animals and patients.” https://pubmed.ncbi.nlm.nih.gov/14683450/

Biosafety of adenoviral vectors - PubMed

Adenoviral vectors can efficiently transduce a broad variety of different cell types and have been used extensively in preclinical and clinical studies. However, early generation of adenoviral...

https://pubmed.ncbi.nlm.nih.gov/14683450/

“While adenovirus vectors are very efficient at delivering genes, adenovirus vectors are not always easy to target to the correct tissue. In addition, adenovirus vectors can cause toxic effects” https://www.fda.gov/vaccines-blood-biologics/biologics-research-projects/safety-and-effectiveness-gene-therapy

Safety and Effectiveness of Gene Therapy

A description of Andrew Byrnes' research program and related publications.

https://www.fda.gov/vaccines-blood-biologics/biologics-research-projects/safety-and-effectiveness-gene-therapy