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Today we're elated to release a set of 30 papers on aerospace medicine and the biology of spaceflight; they are simultaneously featured on the covers of @CellCellPress, @CellReports, & @iScience_CP using photos taken by @StationCDRKelly while in space: https://www.cell.com/c/the-biology-of-spaceflight /1
These manuscripts span >250 investigators from dozens of academic, government, aerospace, & industry groups, representing the largest set of astronaut and SpaceBio data ever produced; thanks to support from @NASA, @WeillCornell, @worldquant, @NIH, @BCMSpaceHealth & many others /2
This includes longitudinal multi-omic profiling, single-cell immune/epitope mapping, @nanopore, @PacBio, & @illumina NGS, novel miRNA radiation countermeasures, and detailed biochemical profiles of 56 astronauts, which represents ~10% of all humans that have ever been in space /3
This collaboration spans the world's 4 largest space agencies: @NASA @JAXA_en @esa @roscosmos & was HUGE team effort: @AfshinBeheshti @DeVlaminckLab @LabMelnick @rosslevinemd @Daniela_Bezdan @smadixit @KellyLBolton @LiorBraunstein @DrDuaneHassane & more https://news.weill.cornell.edu/news/2020/11/studies-reveal-clues-about-preventing-spaceflight-related-risks /4
Highlights include a conversation with @StationCDRKelly about the work with him and Senator-elect @CaptMarkKelly, https://www.cell.com/cell/fulltext/S0092-8674(20)31543-9, as well as the full set of the 15 papers contributed from our lab, including... /5
"Fundamental Biological Features of Spaceflight: Advancing the Field to Enable Deep Space Exploration" with @mjdmackay @jfoox @cemmeydan @AfshinBeheshti showing hallmarks of space biology and needed tools for Mars and missions in the 2020s and 2030s. https://www.cell.com/cell/fulltext/S0092-8674(20)31457-4 /6
"Comprehensive Multi-Omics Analysis Reveals Mitochondrial Stress as a Central Biological Hub for Spaceflight Impact" showing consistent features of mtRNA/mtDNA stress with @AfshinBeheshti @cemmeydan @jfoox @TheHornerLab @mjdmackay @nandangokhale https://www.cell.com/cell/fulltext/S0092-8674(20)31461-6 /7
"Circulating miRNA Spaceflight Signature Reveals Targets for Countermeasure Development" https://www.cell.com/cell-reports/fulltext/S2211-1247(20)31437-6 including a new miRNA radiation treatment, with @danjbuts @Daniela_Bezdan @mjdmackay @LabMelnick @NEBiolabs @AfshinBeheshti and @illumina @BioRad scATAC-seq data /8
"Cell-free DNA (cfDNA) and exosome profiling from a year-long human spaceflight reveals circulating biomarkers" showing a mtDNA biomarker for spaceflight, with @Daniela_Bezdan @cemmeydan @mjdmackay @danjbuts @tejaswini @LabMelnick and @DeVlaminckLab https://www.cell.com/iscience/fulltext/S2589-0042(20)31041-5 /9
"Temporal Telomere and DNA Damage Responses in the Space Radiation Environment" https://www.cell.com/cell-reports/fulltext/S2211-1247(20)31424-8 showing @nanopore measurements of astronaut telomere lengths from in-flight samples, with @Daniela_Bezdan @danjbuts @mjdmackay @jfoox @cemmeydan and Susan Bailey /10
"Telomere Length Dynamics and DNA Damage Responses Associated with Long-Duration Spaceflight" with @smadixit and @climb7moniz who got blood samples from the top of Mt. Everest & @Daniela_Bezdan, @danjbuts, @mjdmackay, @jfoox, @cemmeydan & Susan Bailey
https://www.cell.com/cell-reports/fulltext/S2211-1247(20)31446-7 /11
https://www.cell.com/cell-reports/fulltext/S2211-1247(20)31446-7 /11
"Clonal Hematopoiesis Before, During, and After Human Spaceflight" https://www.cell.com/cell-reports/fulltext/S2211-1247(20)31447-9, showing unique CH metrics & clonal trajectories, w/ @Daniela_Bezdan, @danjbuts, @mjdmackay @jfoox, @cemmeydan @mike_schatz @KellyLBolton @LiorBraunstein @DrDuaneHassane @rosslevinemd /12
"Multi-omic, Single-Cell, and Biochemical Profiles of Astronauts Guide Pharmacological Strategies for Returning to Gravity" with AbSeq and single cell epitope profiles: @Daniela_Bezdan, @danjbuts, @mjdmackay, @jfoox, @cemmeydan, @LabMelnick, @BDandCo https://www.cell.com/cell-reports/fulltext/S2211-1247(20)31418-2 /13
And some papers still in revision: "Haplotype Diversity and Sequence Heterogeneity of Human Telomeres" from Kirill Grigorev showing non-canonical motifs found in telomeres and heritable variants in sub-telomeric regions
https://www.biorxiv.org/content/10.1101/2020.01.31.929307v1 /14
https://www.biorxiv.org/content/10.1101/2020.01.31.929307v1 /14
"Characterization of Spacesuit Associated Microbial Communities and Their Implications for NASA Missions" https://www.researchsquare.com/article/rs-70768/v1 with extensive leadership by @dcdanko and Kasthuri Venkateswaran showing microbes "shoot" out of spacesuits! /15
"Telomere length dynamics in response to DNA damage in malaria parasites" from Jake Reed showing that telomere length can increase even in Plasmodium parasites when you irradiate them, indicating this is not just a human trait https://www.biorxiv.org/content/10.1101/2020.11.08.373563v1 /16
"Genetic and Immunological Evidence for Selective Transfer of Microbes Between the International Space Station and an Astronaut" with @dcdanko here again, showing TCR and bacterial profiles that match during time on the ISS for @StationCDRKelly https://www.biorxiv.org/content/10.1101/2020.11.10.376954v1 /17
"Elevation of Gut-Derived p-Cresol During Spaceflight and its Effect on Drug Metabolism and Performance in Astronauts" showing the interplay of molecules made by the gut vs. the human body in spaceflight https://www.biorxiv.org/content/10.1101/2020.11.10.374645v2 /18
"Engineering Radioprotective Human Cells Using the Tardigrade Damage Suppressor Protein, DSUP" from Craig Westover showing how we can engineer stable cells to protect against radiation using the tardigrade protein DSUP. https://www.biorxiv.org/content/10.1101/2020.11.10.373571v1 /19
Thanks so much to @CellSystemsCP and @Patterns_CP for also highlighting this work in their journals, @AfshinBeheshti and Susan Bailey for the wonderful partnerships, all the work from @CellPressNews and all the amazing editors.
