How does the Sputnik V Vaccine Work - THREAD

So we& #39;ve already assessed how the Pfizer vaccine works. It& #39;s almost identical to the Moderna vaccine. Both are mRNA vaccines transported in a lipid nanoparticle to target cells. The Russian Sputnik V vaccine works differently!

The Sputnik V vaccine uses a modified non-infectious virus called an adenovirus to infect target cells. We& #39;ve spoken previously about how viruses work. However, we only looked at RNA viruses such as COVID. An adenovirus differs because it contains DNA.
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This DNA would encode for the spike protein of COVID-19. It would enter target cells nuclei and be transcribed into mRNA. This mRNA would then be used to produce the spike protein. The schematic below is from the Sputnik V website. Like the others, you& #39;d require 2 dosages.

Adenoviruses have a unique ability to infect a lot of cell types, so it& #39;s likely that they will be modified to only infect certain target cells. The DNA does not integrate into the host cell& #39;s DNA. It remains separate & doesn& #39;t replicate. You won& #39;t end up looking like this guy.

The major differences between the Sputnik V and Moderna/Pfizer vaccines are the genetic material and the method of transport. They are summarised in this table!

I hope you enjoyed that thread! Let us know if you want the resources we used to produce this. Tomorrow we& #39;ll look at the pros and cons of adenoviral based vaccination. See you then!